Locust corpora cardiaca contain an inactive adipokinetic hormone

A neuropeptide from the migratory locust, Locusta migratoria, has been identified as a novel member of the family of adipokinetic hormones (AKHs). The peptide is probably synthesised in the brain because it is the first AKH found in the storage lobe, whilst the three ‘classic' Locusta AKHs are present in the glandular lobe of the corpora cardiaca. In locusts, the peptide has no biological activity usually associated with AKHs. There is only 36–56% sequence identity with the three Lom‐AKHs, but 78% identity with the Drosophila melanogaster AKH, Drm‐HrTH. The new peptide is active in the American cockroach, Periplaneta americana, and was provisionally named ‘L. migratoria hypertrehalosaemic hormone', Lom‐HrTH; its biological role in locusts remains to be established. The high degree of identity with Drm‐HrTH suggests that Lom‐HrTH is an ancient molecule.

• Publication year

  1999

• Venue

  FEBS Letters

• Publication date

  1999-03-26

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0014-5793(99)00299-9PMID 10214953
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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