Modulation of HERG channel inactivation by external cations

No abstract is available for this paper.

• Publication year

  2004

• Venue

  European Biophysics Journal

• Publication date

  2004-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1007/s00249-003-0367-yPMID 14586519
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The anomalous rectification and cation selectivity of the membrane of a starfish egg cell

  2005cited by this paper
• Modulation of human ether‐à‐go‐go‐related K+ (HERG) channel inactivation by Cs+ and K+

  2003influential reference
• IKr: The hERG Channel

  2001cited by this paper
• I(Kr): the hERG channel.

  2001cited by this paper
• Altered gating of HERG potassium channels by cobalt and lanthanum

  2000influential reference
• Permeability Characteristics of Monovalent Cations in Atrial Myocytes of the Rat Heart

  2000influential reference
• A sensitive mechanism for cation modulation of potassium current

  2000cited by this paper
• Modulation of slow inactivation in human cardiac Kv1.5 channels by extra‐ and intracellular permeant cations

  1999cited by this paper
• Modulation of N-type Ca2+ channels by intracellular pH in chick sensory neurons.

  1999cited by this paper
• Effects of outer mouth mutations on hERG channel function: a comparison with similar mutations in the Shaker channel.

  1999influential reference
• A mutation in the pore region of HERG K+ channels expressed in Xenopus oocytes reduces rectification by shifting the voltage dependence of inactivation

  1998cited by this paper
• The moving parts of voltage-gated ion channels

  1998cited by this paper
• A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes

  1997cited by this paper
• Voltage‐ and time‐dependent block of delayed rectifier K+ current in rabbit sino‐atrial node cells by external Ca2+ and Mg2+.

  1996cited by this paper
• Fast inactivation causes rectification of the IKr channel

  1996influential reference
• Use-Dependent Blockers and Exit Rate of the Last Ion from the Multi-Ion Pore of a K+ Channel

  1996cited by this paper
• Dynamic rearrangement of the outer mouth of a K+ channel during gating.

  1996cited by this paper
• Time, voltage and ionic concentration dependence of rectification of h‐erg expressed in Xenopus oocytes

  1996cited by this paper
• Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel.

  1996influential reference
• The inward rectification mechanism of the HERG cardiac potassium channel

  1996influential reference
• HERG, a human inward rectifier in the voltage-gated potassium channel family.

  1995cited by this paper
• The jellyfish green fluorescent protein: a new tool for studying ion channel expression and function.

  1995cited by this paper
• A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome.

  1995cited by this paper
• Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels.

  1993cited by this paper
• Ether-à-go-go encodes a voltage-gated channel permeable to K+ and Ca2+ and modulated by cAMP

  1993influential reference
• Two types of inactivation in Shaker K+ channels: effects of alterations in the carboxy-terminal region.

  1991influential reference
• Tetraethylammonium blockade distinguishes two inactivation mechanisms in voltage-activated K+ channels.

  1991influential reference
• Biophysical and molecular mechanisms of Shaker potassium channel inactivation

  1990cited by this paper
• Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents

  1990cited by this paper
• Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB

  1990cited by this paper
• Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart.

  1987cited by this paper
• Two types of transient outward currents in adult human atrial cells.

  1987cited by this paper
• Rapid recovery from K current inactivation on membrane hyperpolarization in molluscan neurons

  1984cited by this paper
• K+ channels close more slowly in the presence of external K+ and Rb+

  1981influential reference
• Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

  1981cited by this paper
• The ionic channels in excitable membranes.

  1975influential reference

• Effects of Antiarrhythmic Drugs on hERG Gating in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1

  2021cites this paper
• Macroscopic currents of ionic channels using Mass Action Law: A mathematical model

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• K+ Accumulation and Clearance in the Calyx Synaptic Cleft of Type I Mouse Vestibular Hair Cells

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• Role of the activation gate in determining the extracellular potassium dependency of block of HERG by trapped drugs

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• Extracellular potassium dependency of block of HERG by quinidine and cisapride is primarily determined by the permeant ion and not by inactivation.

  2009cites this paper
• CANAUX K + ET QT LONG ACQUIS

  2006cites this paper
• Isolation and characterization of I(Kr) in cardiac myocytes by Cs+ permeation.

  2006cites this paper