Towards a better understanding of the effects of the magnetic nanoparticles size and magnetic field on cellular endocytosis

We present a thermodynamic approach to elucidate the effects of the size of magnetic nanoparticles (MNPs), intensity of magnetic field and biologic parameters on endocytosis under a magnetic field. It is found that the external magnetic field not only results in the increase of endocytic rate, but also can alter the internalized pathway. The minimum and maximum radius for receptor-mediated endocytosis can be calculated by simple straightforward expressions. Furthermore, we constructed a phase diagram to clarify the interrelated effects of MNP radius and magnetic field on endocytosis rate. We can identify from the phase the relations among the size of MNPs, intensity of magnetic field and endocytosis rate. Our theoretical findings can provide useful guidance to the design of MNPs for diagnostic agents and drug delivery applications.

• Publication year

  2020

• Venue

  Journal of Physics D: Applied Physics

• Publication date

  2020-01-24

• Fields of study

  Materials Science, Physics

• Identifiers
  DOI 10.1088/1361-6463/ab6fcc
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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