The IgM antibody isotype of Pertuzumab affords simultaneous binding to antigens, but similar binding in Trastuzumab is hindered by steric clashes.
Not all therapeutic antibody isotypes are equal: the case of IgM versus IgG in Pertuzumab and Trastuzumab† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc04722k
Firdaus Samsudin,J. Yeo,S. Gan,P. Bond
Published 2020 in Chemical Science
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- Publication year
2020
- Venue
Chemical Science
- Publication date
2020-02-12
- Fields of study
Medicine, Chemistry
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- External record
- Source metadata
Semantic Scholar, PubMed
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