From crystal structure to in silico epitope discovery in the Burkholderia pseudomallei flagellar hook‐associated protein FlgK

No abstract is available for this paper.

• Publication year

  2015

• Venue

  The FEBS Journal

• Publication date

  2015-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/febs.13223PMID 25645451
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rational epitope design for protein targeting.

  2013cited by this paper
• Exploiting the Burkholderia pseudomallei acute phase antigen BPSL2765 for structure-based epitope discovery/design in structural vaccinology.

  2013cited by this paper
• A structure-based strategy for epitope discovery in Burkholderia pseudomallei OppA antigen.

  2013cited by this paper
• Structural vaccinology starts to deliver

  2012cited by this paper
• In Vitro and In Vivo Studies of Monoclonal Antibodies with Prominent Bactericidal Activity against Burkholderia pseudomallei and Burkholderia mallei

  2011cited by this paper
• Structural and Biochemical Characterization of NarE, an Iron-containing ADP-ribosyltransferase from Neisseria meningitidis*

  2011cited by this paper
• Human immune responses to Burkholderia pseudomallei characterized by protein microarray analysis.

  2011cited by this paper
• Predicting interaction sites from the energetics of isolated proteins: a new approach to epitope mapping.

  2010cited by this paper
• Exploiting Antigenic Diversity for Vaccine Design

  2010cited by this paper
• Progress toward development of vaccines against melioidosis: A review.

  2010cited by this paper
• Integration, scaling, space-group assignment and post-refinement

  2010cited by this paper
• Prediction of protein-protein interaction sites using electrostatic desolvation profiles.

  2010cited by this paper
• A Burkholderia pseudomallei protein microarray reveals serodiagnostic and cross-reactive antigens

  2009cited by this paper
• MolProbity: all-atom structure validation for macromolecular crystallography

  2009cited by this paper
• Immunogenic Burkholderia pseudomallei Outer Membrane Proteins as Potential Candidate Vaccine Targets

  2009cited by this paper
• Structure-based antigen design: a strategy for next generation vaccines

  2008cited by this paper
• GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation.

  2008cited by this paper
• Roles of Flagellar Hook-Associated Proteins in Vibrio vulnificus Motility and Virulence

  2008cited by this paper
• NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system

  2007cited by this paper
• BALBES: a molecular-replacement pipeline

  2007cited by this paper
• Fitting molecular fragments into electron density

  2007cited by this paper
• Scaling and assessment of data quality.

  2006cited by this paper
• Indirect hemagglutination assay in patients with melioidosis in northern Australia.

  2006cited by this paper
• Biomolecular modeling: Goals, problems, perspectives.

  2006cited by this paper
• The Buccaneer software for automated model building. 1. Tracing protein chains.

  2006cited by this paper
• Characterization of flgK gene and FlgK protein required for H. pylori colonization--from cloning to clinical relevance.

  2006cited by this paper
• Melioidosis: Epidemiology, Pathophysiology, and Management

  2005cited by this paper
• Humoral and Cell-Mediated Adaptive Immune Responses Are Required for Protection against Burkholderia pseudomallei Challenge and Bacterial Clearance Postinfection

  2005cited by this paper
• Coot: model-building tools for molecular graphics.

  2004cited by this paper
• Structure of the bacterial flagellar hook and implication for the molecular universal joint mechanism

  2004cited by this paper
• Adaptive immunity in melioidosis: a possible role for T cells in determining outcome of infection with Burkholderia pseudomallei.

  2004cited by this paper
• Complete atomic model of the bacterial flagellar filament by electron cryomicroscopy

  2003cited by this paper
• Structure validation by Cα geometry: ϕ,ψ and Cβ deviation

  2003cited by this paper
• TopDraw: a sketchpad for protein structure topology cartoons

  2003cited by this paper
• Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility

  2003cited by this paper
• Structure of the bacterial flagellar protofilament and implications for a switch for supercoiling

  2001cited by this paper
• Correspondence e-mail:

  2000cited by this paper
• The Protein Data Bank

  2000cited by this paper
• Peptide Folding: When Simulation Meets Experiment

  1999cited by this paper
• Structural and immunological characterization of Burkholderia pseudomallei O-polysaccharide-flagellin protein conjugates

  1996cited by this paper
• Passive protection of diabetic rats with antisera specific for the polysaccharide portion of the lipopolysaccharide isolated from Pseudomonas pseudomallei.

  1994cited by this paper
• Isolation and characterization of Pseudomonas pseudomallei flagellin proteins

  1994cited by this paper
• The CCP4 suite: programs for protein crystallography.

  1994cited by this paper
• A computer vision based technique for 3-D sequence-independent structural comparison of proteins.

  1993cited by this paper
• An efficient automated computer vision based technique for detection of three dimensional structural motifs in proteins.

  1992cited by this paper
• Localization and stoichiometry of hook-associated proteins within Salmonella typhimurium flagella

  1987cited by this paper
• THE MISSING TERM IN EFFECTIVE PAIR POTENTIALS

  1987cited by this paper
• Locations of hook-associated proteins in flagellar structures of Salmonella typhimurium

  1985cited by this paper
• Correlation between segmental mobility and the location of antigenic determinants in proteins

  1984cited by this paper
• Electronic Reprint Biological Crystallography the Protein Data Bank Biological Crystallography the Protein Data Bank

  year unknowncited by this paper
• The Phenix refinement framework

  year unknowncited by this paper

• Curvature generation and engineering principles from Shewanella oneidensis multi-flagellin flagellum

  2025cites this paper
• Curvature Generation and Engineering Principles from Multi-flagellin Flagellum

  2025cites this paper
• The structure of the complete extracellular bacterial flagellum reveals the mechanism of flagellin incorporation

  2025cites this paper
• Recent advancement, immune responses, and mechanism of action of various vaccines against intracellular bacterial infections.

  2022cites this paper
• Structure and Assembly of the Bacterial Flagellum.

  2022cites this paper
• Evaluation of docking procedures reliability in affitins-partners interactions

  2022cites this paper
• Burkholderia pseudomallei OMVs derived from infection mimicking conditions elicit similar protection to a live-attenuated vaccine

  2021cites this paper
• Antigen Discovery in Bacterial Panproteomes.

  2021cites this paper
• Burkholderia pseudomallei OMVs derived from infection mimicking conditions elicit similar protection to a live-attenuated vaccine

  2021cites this paper
• SARS-CoV-2 Spike Protein Mutations and Escape from Antibodies: A Computational Model of Epitope Loss in Variants of Concern

  2021cites this paper
• Solution Structure of the BPSL1445 Protein of Burkholderia pseudomallei Reveals the SYLF Domain Three-Dimensional Fold.

  2021cites this paper
• Simple Model of Protein Energetics To Identify Ab Initio Folding Transitions from All-Atom MD Simulations of Proteins

  2020cites this paper
• The Answer Lies in the Energy: How Simple Atomistic Molecular Dynamics Simulations May Hold the Key to Epitope Prediction on the Fully Glycosylated SARS-CoV-2 Spike Protein

  2020cites this paper
• Structural study of the flagellar junction protein FlgL from Legionella pneumophila.

  2020cites this paper
• Differential Antibody Recognition by Novel SARS-CoV-2 and SARS-CoV Spike Protein Receptor Binding Domains: Mechanistic Insights and Implications for the Design of Diagnostics and Therapeutics

  2020cites this paper
• Binding Epitopes of 2019-nCoV Proteins for Perspective Diagnostic and Therapeutic Applications: Insights from Computational Approaches

  2020cites this paper
• Immune responses in beta-thalassaemia: heme oxygenase 1 reduces cytokine production and bactericidal activity of human leucocytes

  2020cites this paper
• Novel multi‐component vaccine approaches for Burkholderia pseudomallei

  2019cites this paper
• Epitope mapping of Salmonella flagellar hook-associated protein, FlgK, with mass spectrometry-based immuno-capture proteomics using chicken (Gallus gallus domesticus) sera.

  2018cites this paper
• Flagella-Associated WDR-Containing Protein CrFAP89 Regulates Growth and Lipid Accumulation in Chlamydomonas reinhardtii

  2018cites this paper
• Immune Control of Burkholderia pseudomallei––Common, High-Frequency T-Cell Responses to a Broad Repertoire of Immunoprevalent Epitopes

  2018cites this paper
• Crystal structure of FlgL and its implications for flagellar assembly

  2018cites this paper
• Bacterial flagellar axial structure and its construction

  2018cites this paper
• Crystal structure of Bacillus cereus FlgL

  2018cites this paper
• Targeting Difficult Protein-Protein Interactions with Plain and General Computational Approaches

  2018cites this paper
• Protein design: from computer models to artificial intelligence

  2017cites this paper
• SAGE: A Fast Computational Tool for Linear Epitope Grafting onto a Foreign Protein Scaffold

  2017cites this paper
• Burkholderia pseudomallei and Burkholderia mallei vaccines: Are we close to clinical trials?

  2017cites this paper
• Structure of FlgK reveals the divergence of the bacterial Hook-Filament Junction of Campylobacter

  2017cites this paper
• Structure and Computation in Immunoreagent Design: From Diagnostics to Vaccines.

  2017cites this paper
• Structural Vaccinology for Melioidosis Vaccine Design and Immunodiagnostics

  2017cites this paper
• Infection with Burkholderia pseudomallei – immune correlates of survival in acute melioidosis

  2017cites this paper
• Intracellular replication of the well-armed pathogen Burkholderia pseudomallei.

  2016cites this paper
• Surface energetics and protein-protein interactions: analysis and mechanistic implications

  2016cites this paper
• Virus-like particles as a novel platform for delivery of protective Burkholderia antigens

  2016cites this paper
• Undiscovered regions on the molecular landscape of flagellar assembly.

  2015cites this paper
• Selecting soluble/foldable protein domains through single-gene or genomic ORF filtering: structure of the head domain of Burkholderia pseudomallei antigen BPSL2063.

  2015cites this paper
• Characterization of New Virulence Factors Involved in the Intracellular Growth and Survival of Burkholderia pseudomallei

  2015cites this paper
• Structural and Computational Biology in the Design of Immunogenic Vaccine Antigens

  2015cites this paper