Histidyl-proline diketopiperazine: its biological role as a regulatory peptide

No abstract is available for this paper.

• Publication year

  1982

• Venue

  Molecular and Cellular Biochemistry

• Publication date

  1982-01-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/BF00223538PMID 6278283
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Catabolism of thyroliberin by rat adenohypophyseal tissue extract.

  2005cited by this paper
• Inhibition of abstinence syndrome in opiate dependent mice by cyclo (His-Pro).

  1981cited by this paper
• TRH degradation rates vary widely between different animal species.

  1981cited by this paper
• The subcellular and organ distribution and natural form of histidyl-proline diketopiperazine in rat brain determined by a specific radioimmunoassay.

  1980cited by this paper
• Thyrotropin-releasing hormone has multiple actions in cortex.

  1980cited by this paper
• The neuroendocrine control of appetite: the role of the endogenous opiates, cholecystokinin, TRH, gamma-amino-butyric-acid and the diazepam receptor.

  1980cited by this paper
• Thyrotropin-releasing hormone—CNS action to stimulate gastric acid secretion

  1980cited by this paper
• Specific high affinity cell membrane receptors for biologically active phorbol and ingenol esters

  1980cited by this paper
• Modification of the proline residue of TRH enhances biological activity and inhibits degradation.

  1980cited by this paper
• Induction of wet-dog shakes by intracerebral 'acid' TRH in rats.

  1980cited by this paper
• Thyrotropin releasing hormone stimulation of prolactin release. Evidence for a membrane potential-independent, Ca2+-dependent mechanism of action.

  1980cited by this paper
• Effects of thyrotrophic-releasing hormone (TRH) on thermoregulation in the rat

  1980cited by this paper
• Concentrations of thyrotropin-releasing hormone (TRH) and deamido-TRH, and TRH deamidase activity in brain.

  1980cited by this paper
• Cyclo (His-Pro): a selective inhibitor of rat prolactin secretion in vitro.

  1980cited by this paper
• Immunological blockade of endogenous thyrotropin-releasing hormone produces hypothermia in rats.

  1980cited by this paper
• Thyrotropin-releasing hormone stimulates the release of melanotropin from frog neurointermediate lobes in vitro.

  1980cited by this paper
• Ion-induced release of LHRH, TRH and α-MSH from hypothalamic synaptosomes and its inhibition by vinblastine

  1980cited by this paper
• Evidence for a thyrotropin-releasing hormone inhibitor in the pineal gland.

  1980cited by this paper
• Binding sites for thyrotropin-releasing hormone in sheep nucleus accumbens resemble pituitary receptors.

  1980cited by this paper
• Thyrotropin releasing hormone (TRH) suppresses stress induced eating.

  1980cited by this paper
• Enhancement by Gangliosides of the Binding of Serotonin to Serotonin Binding Protein

  1980cited by this paper
• Changes in adenylate cyclase activity in rat pituitary after TRH and T3 injection in vivo.

  1980cited by this paper
• Size heterogeneity of plasma prolactin in the rat: TRH and serotonin-induced changes.

  1980cited by this paper
• Further studies on the inactivation of thyrotrophin releasing hormone (TRH) by enzymes in the rat hypothalamus.

  1980cited by this paper
• The effects of thyrotropin releasing hormone and histidyl-proline diketopiperazine on delta-9-tetrahydrocannabinol-induced hypothermia.

  1980cited by this paper
• Cyclo (leucylglycine) inhibits the development of morphine induced analgesic tolerance and dopamine receptor supersensitivity in rats.

  1980cited by this paper
• Evidence that serotonin is involved in prolactin release by electrical stimulation of the medial basal hypothalamus in the rhesus monkey.

  1980cited by this paper
• Release of somatostatin and thyrotropin-releasing hormone from rat hypothalamic fragments in vitro.

  1980cited by this paper
• Cyclo (His-Pro): A selective inhibitor of rat prolactin secretion in vitro

  1980cited by this paper
• Effects of triiodothyronine on thyrotropin-releasing hormone-induced thyrotropin release in the neonatal rat.

  1980cited by this paper
• A prolactin inhibitory factor with immunocharacteristics similar to thyrotropin releasing factor (TRH) is present in rat pituitary tumors (GH3 and W5), testicular tissue and a plant material, alfalfa.

  1980cited by this paper
• Histidyl-proline diketopiperazine, an endogenous brain peptide that inhibits (Na+ + K+)-ATPase.

  1980cited by this paper
• Antagonism of ethanol-induced decrease in rat brain cGMP concentration by histidyl-proline diketopiperazine, a thyrotropin releasing hormone metabolite.

  1979cited by this paper
• L-[3H]Carnosine binding in the olfactory bulb. II. Biochemical and biological studies.

  1979cited by this paper
• Blockage of narcotic-induced dopamine receptor supersensitivity by cyclo(Leu-Gly).

  1979cited by this paper
• Release of [3H]serotonin and its binding protein from enteric neurons.

  1979cited by this paper
• STORAGE OF SEROTONIN AND SEROTONIN BINDING PROTEIN IN SYNAPTIC VESICLES

  1979cited by this paper
• THYROTROPHIN RELEASING HORMONE STIMULATES RELEASE OF [3H]‐DOPAMINE FROM SLICES OF RAT NUCLEUS ACCUMBENS in vitro

  1979cited by this paper
• Inhibition of in vitro prolactin secretion by histidyl-proline-diketopiperazine, a degradation product of TRH.

  1979cited by this paper
• Characterization of a thyroliberin-degrading serum enzyme catalyzing the hydrolysis of thyroliberin at the pyroglutamyl-histidine bond.

  1979cited by this paper
• Plasma clearance and plasma half-disappearance time of exogenous thyrotropin-releasing hormone and pyroglutamyl-N3im-methyl-histidyl prolineamide.

  1979cited by this paper
• Extrahypothalamic thyrotropin releasing hormone (TRH) -- its distribution and its functions.

  1979cited by this paper
• Plasma growth hormone and thyrotropin responses to thyrotropin releasing hormone in freely behaving and urethane anesthetized rats.

  1979cited by this paper
• Plasma groeth hormone and thyrotropin responses to thyrotropin releasing hormone in freely behaving and urethane anesthetized rats

  1979cited by this paper
• Thermoregulation in rats: opposing effects of thyrotropin releasing hormone and its metabolite histidyl-proline diketopiperazine.

  1978cited by this paper
• Regulation of pituitary receptors for thyrotropin-releasing hormone by thyroid hormones.

  1978cited by this paper
• Inhibition of prolactin secretion by histidyl-proline-diketopiperazine

  1978cited by this paper
• Estrogen control of prolactin synthesis in vitro.

  1978cited by this paper
• Thyrotropin-releasing hormone reversal of ethanol-induced decreases in cerebellar cGMP

  1978cited by this paper
• Ligand binding studies in the mouse olfactory bulb: identification and characterization of a L-[3H]carnosine binding site.

  1978cited by this paper
• The developmental pattern of thyrotropin-releasing hormone-degrading activity in the plasma of rats.

  1978cited by this paper
• Benzodiazepine receptors in rat brain

  1977cited by this paper
• Thyrotropin-releasing hormone: stimulation of colonic activity following intracerebroventricular administration.

  1977cited by this paper
• An enzymatically stable peptide with activity in the central nervous system: its penetration through the blood-CSF barrier.

  1977cited by this paper
• Regulatory peptides of the hypothalamus.

  1977cited by this paper
• Antagonism of ethanol narcosis by histidyl-proline diketopiperazine

  1977cited by this paper
• Stimulation of prolactin synthesis and of adenosine 3':5'-cyclic phosphate formation by prostaglandins and thyroliberin in cultured rat pituitary cells.

  1976cited by this paper
• Inhibition of (Na+, K+)adenosine triphosphatase and its partial reactions by quercetin.

  1976cited by this paper
• Demonstration of pyroglutamylpeptidase and amidase activities toward thyrotropin-releasing hormone in hamster hypothalamus extracts.

  1976cited by this paper
• Thyrotropin-releasing hormone regulates the number of its own receptors in the GH3 strain of pituitary cells in culture.

  1975cited by this paper
• The effect of dexamethasone on TSH and prolactin secretion after TRH stimulation.

  1974cited by this paper
• Effect of somatostatin (growth hormone inhibiting factor: GIF) on TRH-induced TSH release in rats.

  1974cited by this paper
• Receptor-binding affinities and biological activities of analogs of thyrotropin-releasing hormone in prolactin-producing pituitary cells in culture.

  1974cited by this paper
• Thyroid hormone action: stimulation of growth hormone and inhibition of prolactin secretion in cultured GH1 cells.

  1974cited by this paper
• Antagonism of ethanol narcosis by thyrotropin releasing hormone.

  1974cited by this paper

• The Type of Fat in the Diet Influences Regulatory Aminopeptidases of the Renin-Angiotensin System and Stress in the Hypothalamic-Pituitary-Adrenal Axis in Adult Wistar Rats

  2021cites this paper
• Tyrosine-based photoluminescent diketopiperazine supramolecular aggregates.

  2021cites this paper
• The forgotten effects of thyrotropin-releasing hormone: Metabolic functions and medical applications.

  2019cites this paper
• 2,5-diketopiperazines as neuroprotective agents.

  2012cites this paper
• Development and testing of liposome encapsulated cyclic dipeptides

  2011cites this paper
• NEUROPROTECTIVE EFFECT OF THYROTROPIN-RELEASING HORMONE (TRH) AGAINST GLUTAMATE TOXICITY IN VITRO

  2009cites this paper
• The different facets of protein kinases C: old and new players in neuronal signal transduction pathways.

  2006cites this paper
• IncreasedExcretionof Histidyl-L-ProlineDiketopiperazineby Infants ReceivingPregestimiland NutramigenFormulas

  2004cites this paper
• Neuropeptides TRH and cyclo(His-Pro) share neuromodulatory, but not stimulatory, action on hypothalamic neurons in vitro: implication for the regulation of feeding

  2004cites this paper
• Effects of thyrotropin releasing hormone on human sudomotor and cutaneous vasomotor activities

  2004cites this paper
• Synthesis and biological activity of novel neuroprotective diketopiperazines.

  2002cites this paper
• The biology of pro-thyrotropin-releasing hormone-derived peptides.

  1999cites this paper
• Pyroglutamyl peptidase: an overview of the three known enzymatic forms.

  1998cites this paper
• Thyrotropin-releasing hormone.

  1995cites this paper
• Pyrrolidone carboxyl peptidase (Pcp): An enzyme that removes pyroglutamic acid (pGlu) from pGlu‐peptides and pGlu‐proteins

  1994cites this paper
• The regulation of prolactin cells in the rainbow trout (Oncorhynchus mykiss). 1. Possible roles for thyrotropin-releasing hormone (TRH) and oestradiol.

  1994cites this paper
• Effect of acute lithium administration on pyroglutamyl-aminopeptidase I activity in several brain areas of the rat.

  1994cites this paper
• The regulation of prolactin cells in the rainbow trout (Oncorhynchus mykiss). 2. Somatostatin.

  1994cites this paper
• Dual modulation of K+ currents and cytosolic Ca2+ by the peptide TRH and its derivatives in guinea‐pig septal neurones.

  1993cites this paper
• Effects of two diketopiperazines, cyclo (His-Pro) and cyclo (Asp-Phe), on striatal dopamine: a microdialysis study.

  1993cites this paper
• A fast protein liquid chromatography (FPLC) method for study of thyrotropin-releasing hormone (TRH) and its metabolite histidyl-proline diketopiperazine (CHP) in human blood: degradation in liver and pancreatic diseases.

  1993cites this paper
• Pyroglutamyl [correction of Pyroglutamil] -peptidase I activity in the cortex of the cat brain during development.

  1992cites this paper
• Carnosine: its properties, functions and potential therapeutic applications.

  1992cites this paper
• Pyroglutamate aminopeptidase in rat submaxillary gland.

  1992cites this paper
• Evidence for pyroglutamyl peptidase I and prolyl endopeptidase activities in the rat insulinoma cell line RINm 5F: lack of relationship with TRH metabolism

  1991cites this paper
• Thyrotropin-releasing hormone facilitates display of reproductive behavior and locomotor behavior in an amphibian.

  1991cites this paper
• Kinetics and Pattern of Degradation of Thyrotropin-Releasing Hormone (TRH) in Human Plasma

  1990cites this paper
• [Thyrotropin-releasing hormone: the anniversary of a neurohormone].

  1990cites this paper
• Systemic administration of thyrotropin-releasing hormone enhances striatal dopamine release in vivo.

  1990cites this paper
• Casein: A Milk Protein with Diverse Biologic Consequences

  1990cites this paper
• Kinetics and Mechanism of the Facile Cyclization of Histidyl‐prolineamide to Cyclo (His‐Pro) in Aqueous Solution and the Competitive Influence of Human Plasma

  1990cites this paper
• Degradation of Thyrotropin‐Releasing Hormone and Luteinising Hormone‐Releasing Hormone by Enzymes of Brain Tissue

  1990cites this paper
• Antioxidative activity of cyclohistidylproline

  1989cites this paper
• Histidyl proline diketopiperazine (Cyclo [His-Pro]) in eating disorders.

  1989cites this paper
• Characterization and Solubilization of Cyclo(His-Pro) Binding from Rat Liver Membranes 1

  1989cites this paper
• Rapid separation of tritiated thyrotropin-releasing hormone and its catabolic products from mouse and human central nervous system tissues by high-performance liquid chromatography with radioactive flow detection.

  1989cites this paper
• Pituitary TRH Receptors a

  1989cites this paper
• A comparative study of synthetic carnosine analogs as antioxidants.

  1989cites this paper
• Re-evaluation of histidyl-proline diketopiperazine [cyclo(His-Pro)] effects on food intake in the rat.

  1988cites this paper
• Long-term effects of thyrotropin-releasing hormone and histidyl-proline diketopiperazine on the maturation of homeothermia and mitochondrial enzyme activities in neonatal rats.

  1988cites this paper
• Neuromodulatory actions of peptides.

  1988cites this paper
• Antinociceptive activity of TRH metabolites in the mouse

  1987cites this paper
• Pituitary and hypothalamic hormones in normal and neoplastic adrenal medullae: biologically active corticotropin-releasing hormone and corticotropin.

  1987cites this paper
• Neural functions of TRH.

  1986cites this paper
• Amyotrophic lateral sclerosis

  1986cites this paper
• Effects of thyrotropin-releasing hormone and cyclo-histidine-proline on the homeothermic development of neonatal rats.

  1986cites this paper
• Mechanism of antidepressant and learning-stimulating effects of thyrotropin releasing hormone and its analogs

  1986cites this paper
• Increased excretion of histidyl-L-proline diketopiperazine by infants receiving Pregestimil and Nutramigen formulas.

  1986cites this paper
• Biosynthesis, metabolism and role of TRH during the perinatal period (minireview).

  1986cites this paper
• Subcellular distribution of the enzymes degrading thyrotropin releasing hormone and metabolites in rat brain.

  1986cites this paper
• Intraventricular Administration of Cyclo(His-Pro), a Metabolite of Thyrotropin-Releasing Hormone (TRH), Decreases Water Intake in the Rat 1

  1985cites this paper
• Effects of TRH, cyclo-(His-Pro) and (3-Me-His2)TRH on identified septohippocampal neurons in the rat

  1985cites this paper
• Histidyl-proline-diketopiperazine (cyclo-his-pro) inhibits the suckling- and domperidone-induced transformation of prolactin in the lactating rat.

  1985cites this paper
• Analog specificity of the thyrotropin-releasing hormone receptor in the central nervous system: possible clinical implications.

  1985cites this paper
• Synthesis, characterization, and anorectic testing of the four stereoisomers of cyclo(histidylproline).

  1985cites this paper
• Involvement of the Autonomic Nervous System in the In Vivo TRH-Induced Increases in the Plasma Levels of Glucagon, Insulin and Glucose in Rabbits

  1985cites this paper
• Presence of a membrane bound pyroglutamyl amino peptidase degrading thyrotropin releasing hormone in rat brain.

  1985cites this paper
• Changes in body temperature after administration of amino acids, peptides, dopamine, neuroleptics and related agents: II.

  1985cites this paper
• Pharmacological profile of wet-dog shaking induced by electrical stimulation of the fornix in rats.

  1984cites this paper
• Effect of thyrotropin-releasing hormone and its metabolites on the secretion of sulfated polysaccharides by foot integument of a pond snail.

  1984cites this paper
• Unresponsiveness of GH cells to cyclo(histidyl-proline), a metabolite of thyrotropin releasing hormone.

  1984cites this paper
• METABOLISM OF THYROTROPIN RELEASING HORMONE AND ITS POSSIBLE RELEVANCE TO PROLACTIN SECRETION

  1984cites this paper
• Regulation of thyrotropin-releasing hormone binding by monovalent cations and guanyl nucleotides.

  1984cites this paper
• The pharmacokinetics of thyrotropin-releasing hormone (TRH) and deamido-TRH in the rat.

  1984cites this paper
• In vitro biochemical characterization and autoradiographic distribution of 3H-thyrotropin-releasing hormone binding sites in rat brain sections.

  1984cites this paper
• Biotransformation of neuropeptides.

  1984cites this paper
• Pituitary and hypothalamic hormones as precursor molecules of neuropeptides.

  1983cites this paper
• Actions of TRH and cyclo-(His-Pro) on spontaneous and evoked activity of cortical neurones.

  1983cites this paper
• Enzymic inactivation of hypothalamic regulatory hormones.

  1983cites this paper
• Detection in human serum by radioimmunoassay of histidyl-proline diketopiperazine, a metabolite of thyrotropin-releasing hormone.

  1983cites this paper
• Induction of wet-dog shaking in rats by analogues and metabolites of thyrotrophin-releasing hormone (TRH).

  1982cites this paper
• Mechanisms of brain inactivation of centrally-acting thyrotrophin-releasing hormone (TRH) analogues: a high-performance liquid chromatography study.

  1982cites this paper