Epigenetic dysregulation in Epstein-Barr virus-associated gastric carcinoma: disease and treatments.

Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) comprises nearly 10% of gastric carcinoma cases worldwide. Recently, it was recognised to have unique clinicopathologic characteristics, including male predominance, lower rates of lymph node involvement, and better prognosis. EBVaGC is further characterised by abnormal hypermethylation of tumour suppressor gene promoter regions, causing down-regulation of their expression. In the present review, we critically discuss the role of EBV in gastric carcinogenesis, summarising the role of viral proteins and microRNAs with respect to aberrant methylation in EBVaGC. Given the role of epigenetic dysregulation in tumourigenesis, epigenetic modifiers may represent a novel therapeutic strategy.

• Publication year

  2014

• Venue

  World Journal of Gastroenterology

• Publication date

  2014-06-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3748/wjg.v20.i21.6448PMID 24914366PMCID PMC4047330
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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