Rethinking T cell immunity in oropharyngeal candidiasis

The disproportionate increase in oropharyngeal candidiasis (OPC) compared with systemic and vaginal candidiasis in female patients with AIDS has been a paradox for almost three decades. New data now show that severe OPC develops in Th17-deficient mice, but not Th1-deficient mice, implicating Th17-induced effector molecules in resistance to oral disease. These findings clarify and extend our current thinking about how CD4 T cell deficiency influences susceptibility to OPC.

• Publication year

  2009

• Venue

  Journal of Experimental Medicine

• Publication date

  2009-02-16

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1084/jem.20090093PMID 19204107PMCID 2646576
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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