Alloimmunization in Chronically Transfused Patients and Those With Malignancies

Abstract Red blood cell (RBC) transfusion is a life-saving therapy for many patients, but it is a prominent part of therapy for thalassemia, sickle cell disease, and patients with malignancies. RBC alloimmunization is a therapy-limiting complication of RBC transfusion, and its prevalence and causes are linked most to the amount of exposure to allogeneic transfusions, but antigen disparity between donor and recipient as well as recipient genetic predisposition and concomitant therapy also factor into how likely a patient is to experience this complication.

• Publication year

  2020

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  Unknown venue

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  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/b978-0-323-67509-3.00011-1
• External record

  Open on Semantic Scholar

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  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Beta Thalassemia

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  2019cited by this paper
• Clinical outcome of transfusions with extended red blood cell matching in β-thalassemia patients: A single-center experience.

  2019cited by this paper
• Red blood cell alloimmunization in sickle cell disease: assessment of transfusion protocols during two time periods

  2018cited by this paper
• Red blood cell specifications for patients with hemoglobinopathies: a systematic review and guideline

  2018cited by this paper
• Prevalence and clinical significances of red cell alloimmunization and red cell bound immunoglobulin G in polytransfused patients with thalassemias

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• Risks of red blood cell alloimmunization in transfusion‐dependent β‐thalassemia in Oman: a 25‐year experience of a university tertiary care reference center and a literature review

  2018cited by this paper
• Red Blood Cell Alloimmunization in Korean Patients With Myelodysplastic Syndrome and Liver Cirrhosis

  2018cited by this paper
• The prevalence, alloimmunization risk factors, antigenic exposure, and evaluation of antigen‐matched red blood cells for thalassemia transfusions: a 10‐year experience at a tertiary care hospital

  2018cited by this paper
• Risk factors for red blood cell alloimmunization in the Recipient Epidemiology and Donor Evaluation Study (REDS‐III) database

  2018cited by this paper
• How I manage medical complications of β-thalassemia in adults.

  2018cited by this paper
• Clinical Classification, Screening and Diagnosis for Thalassemia.

  2018cited by this paper
• Transfusion in Head and Neck Cancer Patients Undergoing Pedicled Flap Reconstruction

  2018cited by this paper
• Transfusion practices and complications in thalassemia

  2018cited by this paper
• Mechanisms of red blood cell transfusion‐related immunomodulation

  2018cited by this paper
• Optimized Antigen-Matched in Sickle Cell Disease Patients: Chances and Challenges in Molecular Times - the Brazilian Way

  2018cited by this paper
• Preoperative anemia and perioperative blood transfusion in head and neck squamous cell carcinoma

  2018cited by this paper
• A locus on chromosome 5 shows African ancestry-limited association with alloimmunization in sickle cell disease.

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• Prevalence of Thalassemia among Newborns: A Re-visited after 20 Years of a Prevention and Control Program in Northeast Thailand

  2018cited by this paper
• Treatments for hematologic malignancies in contrast to those for solid cancers are associated with reduced red cell alloimmunization

  2017cited by this paper
• Absence of the spleen and the occurrence of primary red cell alloimmunization in humans

  2017cited by this paper
• ‐318C/T polymorphism of the CTLA‐4 gene is an independent risk factor for RBC alloimmunization among sickle cell disease patients

  2017cited by this paper
• Red blood cell alloimmunization in patients with sickle cell disease: correlation with HLA and cytokine gene polymorphisms

  2017cited by this paper
• Nonclassical FCGR2C haplotype is associated with protection from red blood cell alloimmunization in sickle cell disease.

  2017cited by this paper
• Sickle cell disease

  2017cited by this paper
• Whole-exome sequencing for RH genotyping and alloimmunization risk in children with sickle cell anemia.

  2017cited by this paper
• Red cell alloimmunization is associated with development of autoantibodies and increased red cell transfusion requirements in myelodysplastic syndrome

  2017cited by this paper
• Red blood cell alloimmunization in 184 patients with myeloid neoplasms treated with azacitidine - A retrospective single center experience.

  2017cited by this paper
• Preoperative anemia, blood transfusion, and neutrophil-to-lymphocyte ratio in patients with stage i non-small cell lung cancer.

  2016cited by this paper
• Protective effect of HLA-DQB1 alleles against alloimmunization in patients with sickle cell disease.

  2016cited by this paper
• Perioperative Blood Transfusion as a Significant Predictor of Biochemical Recurrence and Survival after Radical Prostatectomy in Patients with Prostate Cancer

  2016cited by this paper
• Platelet refractoriness – practical approaches and ongoing dilemmas in patient management

  2015cited by this paper
• Phenotypic differences of CD4+ T cells in response to red blood cell immunization in transfused sickle cell disease patients

  2015cited by this paper
• Immunohematologic tolerance of chronic transfusion exchanges with erythrocytapheresis in sickle cell disease

  2015cited by this paper
• Red cell alloimmunization in multi-transfused patients with sickle cell anemia in Benin City, Nigeria.

  2015cited by this paper
• Alloimmunization is associated with older age of transfused red blood cells in sickle cell disease

  2015cited by this paper
• Factors Influencing RBC Alloimmunization: Lessons Learned from Murine Models

  2014cited by this paper
• Predictors of red cell alloimmunization in multitransfused Egyptian patients with β-thalassemia.

  2014cited by this paper
• Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members.

  2014cited by this paper
• Red blood cell alloimmunization is influenced by recipient inflammatory state at time of transfusion in patients with sickle cell disease

  2013cited by this paper
• High prevalence of red blood cell alloimmunization in sickle cell disease despite transfusion from Rh-matched minority donors.

  2013cited by this paper
• Study of possible clinical and laboratory predictors of alloimmunization against red blood cell antigens in cancer patients

  2013cited by this paper
• Alloimmunization in sickle cell anemia in the era of extended red cell typing

  2013cited by this paper
• Red blood cell alloimmunization in transfused patients with myelodysplastic syndrome or chronic myelomonocytic leukemia

  2013cited by this paper
• Lower alloimmunization rates in pediatric sickle cell patients on chronic erythrocytapheresis compared to chronic simple transfusions

  2012cited by this paper
• Red cell alloimmunization in a diverse population of transfused patients with thalassaemia

  2011cited by this paper
• Extended red blood cell antigen matching for transfusions in sickle cell disease: a review of a 14‐year experience from a single center (CME)

  2011cited by this paper
• Red blood cell alloimmunization in sickle cell disease patients in Uganda

  2010cited by this paper
• [Pathophysiology of sickle cell disease].

  2010cited by this paper
• IMMUNOHEMATOLOGY: Storage of murine red blood cells enhances alloantibody responses to an erythroid‐specific model antigen

  2009cited by this paper
• rs660 polymorphism in Ro52 (SSA1; TRIM21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease.

  2009cited by this paper
• Inflammation enhances consumption and presentation of transfused RBC antigens by dendritic cells.

  2007cited by this paper
• Mailing of a sickle cell disease educational packet increases blood donors within an African American community

  2006cited by this paper
• Recipient inflammation affects the frequency and magnitude of immunization to transfused red blood cells

  2006cited by this paper
• Allosensitization in Patients Receiving Multiple Blood Transfusions

  2005cited by this paper
• Clinical significance of RBC alloantibodies and autoantibodies in sickle cell patients who received transfusions

  2002cited by this paper
• The contribution of sociodemographic, medical, and attitudinal factors to blood donation among the general public

  2002cited by this paper
• Absence of anti‐D alloimmunization in hematologic patients after D‐incompatible platelet transfusions

  2002cited by this paper
• Red cell antibodies in patients with homozygous sickle cell disease: a comparison of patients in Jamaica and the United Kingdom

  2001cited by this paper
• Prospective RBC phenotype matching in a stroke‐prevention trial in sickle cell anemia: a multicenter transfusion trial

  2001cited by this paper
• Red cell antibodies in frequently transfused patients with myelodysplastic syndrome

  2001cited by this paper
• Alloimmunization and erythrocyte autoimmunization in transfusion-dependent thalassemia patients of predominantly asian descent.

  2000cited by this paper
• Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography.

  1998cited by this paper
• A moderate transfusion regimen may reduce iron loading in beta‐ thalassemia major without producing excessive expansion of erythropoiesis

  1997cited by this paper
• Low incidence of red cell and HLA antibody formation by bone marrow transplant patients

  1995cited by this paper
• Antigen‐matched donor blood in the transfusion management of patients with sickle cell disease

  1994cited by this paper
• Alloimmunization in sickle cell anemia and transfusion of racially unmatched blood.

  1990cited by this paper
• Transfusion and alloimmunization in sickle cell disease. The Cooperative Study of Sickle Cell Disease.

  1990cited by this paper
• HLA-B35 is associated with red cell alloimmunization in sickle cell disease.

  1986cited by this paper
• Chronic transfusions in patients with sickle cell disease. Indications and problems.

  1985cited by this paper
• Immune Response to Chronic Red Blood Cell Transfusion

  1983cited by this paper
• Transfusion requirements and splenectomy in thalassemia major.

  1980cited by this paper
• Frequency of Antibodies to Various Antigenic Determinants in Polytransfused Patients with Homozygous Thalassaemia in Greece

  1971cited by this paper
• Transfusion Therapy in Cooley's Anemia: Growth and Health as Related to Long‐Range Hemoglobin Levels. A Progress Report

  1964cited by this paper

• HLA Class II regulation of immune response in sickle cell disease patients: Susceptibility to red blood cell alloimmunization (systematic review and meta‐analysis)

  2022cites this paper