Long-term administration of Lactobacillus casei Zhang stabilized gut microbiota of adults and reduced gut microbiota age index of older adults

Abstract Gut microbiota is closely associated with human health, but limited information is available on the impact of long-term probiotic consumption on age-specific gut microbiota changes. We analyzed the effect of ingesting Lactobacillus casei Zhang (LcZ) on adult and older adult gut microbiota over 12-months in a randomized, placebo-controlled, and double-blind study. Forty subjects (n = 10 per group) were classified into four groups (adult-placebo, adult-probiotic, older adult-placebo, and older adult-probiotic). Ingesting LcZ benefited the adult and older adult populations differently. Consuming LcZ exerted a faster and stronger gut microbiota stabilizing effect to the adult-probiotic group compared with its placebo group, while such effect was less observed among older adults. Meanwhile, LcZ shifted the gut microbiota age index of the probiotic-receiving but not placebo-receiving older adults to resemble that of the adult population. Furthermore, some novel age-linked markers were identified. Taken altogether, long-term administration of LcZ modulated gut microbiota in an age-dependent manner.

• Publication year

  2020

• Venue

  Journal of Functional Foods

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.jff.2019.103682
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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