Ursolic acid induces PC‐3 cell apoptosis via activation of JNK and inhibition of Akt pathways in vitro

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Molecular Carcinogenesis

• Publication date

  2010-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/mc.20610PMID 20146252
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanism of 2‐methoxyestradiol‐induced apoptosis and growth arrest in human breast cancer cells

  2009cited by this paper
• Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis

  2009cited by this paper
• Ursolic acid inhibits IL‐1β or TNF‐α‐induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC‐ζ and downregulating the MMP‐9 expression

  2009cited by this paper
• Gambogic acid, a potent inhibitor of survivin, reverses docetaxel resistance in gastric cancer cells.

  2008cited by this paper
• Critical roles for JNK, c‐Jun, and Fas/FasL‐Signaling in vitamin E analog‐induced apoptosis in human prostate cancer cells

  2008cited by this paper
• Apoptotic signaling in bufalin‐ and cinobufagin‐treated androgen‐dependent and ‐independent human prostate cancer cells

  2008cited by this paper
• Cancer Statistics, 2008

  2008cited by this paper
• Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells

  2008cited by this paper
• Gα12 Stimulates Apoptosis in Epithelial Cells through JNK1-mediated Bcl-2 Degradation and Up-regulation of IκBα*

  2007cited by this paper
• Oleandrin induces apoptosis in human, but not in murine cells: dephosphorylation of Akt, expression of FasL, and alteration of membrane fluidity.

  2007cited by this paper
• Ursolic acid, a naturally occurring triterpenoid, demonstrates anticancer activity on human prostate cancer cells

  2007cited by this paper
• Molecular features of hormone-refractory prostate cancer cells by genome-wide gene expression profiles.

  2007cited by this paper
• Regulation of the Phosphatidylinositol 3-Kinase-Akt and the Mitogen-Activated Protein Kinase Pathways by Ursolic Acid in Human Endometrial Cancer Cells

  2007cited by this paper
• Activation of PI3K‐Akt signaling pathway promotes prostate cancer cell invasion

  2007influential reference
• Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells.

  2007cited by this paper
• Induction of Apoptosis and Regulation of the MAPK Pathway by Ursolic Acid in Human Leukemia K562 Cells

  2007cited by this paper
• Antiproliferative and antiviral mechanisms of ursolic acid and dexamethasone in cervical carcinoma cell lines

  2006cited by this paper
• Molecular targets of dietary agents for prevention and therapy of cancer.

  2006cited by this paper
• Inhibition of the phosphatidylinositol 3'-kinase pathway promotes autocrine Fas-induced death of phosphatase and tensin homologue-deficient prostate cancer cells.

  2006cited by this paper
• Ursolic acid promotes the release of macrophage migration inhibitory factor via ERK2 activation in resting mouse macrophages.

  2005cited by this paper
• Oleanolic acid and ursolic acid: research perspectives.

  2005cited by this paper
• Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and caspase‐3 activation in M4Beu melanoma cells

  2005cited by this paper
• Akt inhibition upregulates FasL, downregulates c-FLIPs and induces caspase-8-dependent cell death in Jurkat T lymphocytes

  2005cited by this paper
• Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells.

  2004cited by this paper
• A Link between Benzyl Isothiocyanate-Induced Cell Cycle Arrest and Apoptosis: Involvement of Mitogen-Activated Protein Kinases in the Bcl-2 Phosphorylation

  2004influential reference
• Microglial cell death induced by a low concentration of polyamines.

  2003cited by this paper
• Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells

  2003cited by this paper
• The CD95(APO-1/Fas) DISC and beyond

  2003cited by this paper
• Multifunctional role of Fas-associated death domain protein in apoptosis.

  2002cited by this paper
• Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells.

  2002cited by this paper
• Effects of ursolic acid and oleanolic acid on human colon carcinoma cell line HCT15.

  2002cited by this paper
• Molecular Ordering of the Initial Signaling Events of CD95

  2002cited by this paper
• Adenovirus-mediated expression of antisense MMP-9 in glioma cells inhibits tumor growth and invasion

  2002cited by this paper
• Matrix metalloproteinases: a tail of a frog that became a prince

  2002cited by this paper
• Cellular stress response and apoptosis in cancer therapy.

  2001cited by this paper
• Phosphorylation of Bcl2 and regulation of apoptosis

  2001cited by this paper
• Mammalian MAP kinase signalling cascades

  2001cited by this paper
• Oncogenic kinase signalling

  2001cited by this paper
• Activation of caspase-3 protease during the process of ursolic acid and its derivative-induced apoptosis.

  2001cited by this paper
• BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.

  2001cited by this paper
• SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

  2001influential reference
• Programmed cell death: alive and well in the new millennium.

  2001cited by this paper
• [Mitochondria and apoptosis].

  2000cited by this paper
• Induction of apoptosis by ursolic acid through activation of caspases and down-regulation of c-IAPs in human prostate epithelial cells.

  2000cited by this paper
• Vinblastine-induced Phosphorylation of Bcl-2 and Bcl-XL Is Mediated by JNK and Occurs in Parallel with Inactivation of the Raf-1/MEK/ERK Cascade*

  2000influential reference
• Insights into programmed cell death through structural biology.

  2000cited by this paper
• Dissecting the pathways to death

  2000cited by this paper
• Apoptotic activity of ursolic acid may correlate with the inhibition of initiation of DNA replication

  2000cited by this paper
• Cyclic adenosine monophosphate inhibits ursolic acid-induced apoptosis via activation of protein kinase A in human leukaemic HL-60 cells.

  2000cited by this paper
• FasL:Fas ratio--a prognostic factor in breast carcinomas.

  2000cited by this paper
• The death receptors.

  1999cited by this paper
• Biochemical pathways of caspase activation during apoptosis.

  1999cited by this paper
• Apoptosis control by death and decoy receptors.

  1999cited by this paper
• Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.

  1999cited by this paper
• Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression.

  1998influential reference
• Mitochondria and apoptosis.

  1998cited by this paper
• Intracellular Ca2+ release mediates ursolic acid–induced apoptosis in human leukemic HL‐60 cells

  1997cited by this paper
• Inhibitory effect of ursolic acid on B16 proliferation through cell cycle arrest.

  1996cited by this paper
• P-glycoprotein-mediated acquired multidrug resistance of human lung cancer cells in vivo.

  1996cited by this paper
• Taxol induces bcl-2 phosphorylation and death of prostate cancer cells.

  1996cited by this paper
• Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells.

  1996cited by this paper
• Anti-angiogenic activity of triterpene acids.

  1995cited by this paper
• Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid.

  1994cited by this paper
• Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.

  1993cited by this paper
• Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

  1993cited by this paper
• Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation.

  1991cited by this paper
• Cancer statistics

  1989cited by this paper
• Inhibition of the tumor-promoting action of 12-O-tetradecanoylphorbol-13-acetate by some oleanane-type triterpenoid compounds.

  1988cited by this paper
• Measurement of protein using bicinchoninic acid.

  1985cited by this paper
• Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.

  1983cited by this paper

• Mechanistic insights and clinical perspectives on anticancer natural compounds from dietary polyphenols

  2025cites this paper
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  2023cites this paper
• Ursolic Acid against Prostate and Urogenital Cancers: A Review of In Vitro and In Vivo Studies

  2023cites this paper
• Natural compounds ursolic acid and digoxin exhibit inhibitory activities to cancer cells in RORγ-dependent and -independent manner

  2023cites this paper
• Gold nanoparticles loaded chitosan encapsulate 6-mercaptopurine as a novel nanocomposite for chemo-photothermal therapy on breast cancer

  2022cites this paper
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  2022cites this paper
• Metagenomic insights into the rumen epithelial integrity responses to the vitamin B1 supplement under high-concentrate diets treatments

  2022cites this paper
• Ursolic acid inhibits the activation of smoothened‐independent non‐canonical hedgehog pathway in colorectal cancer by suppressing AKT signaling cascade

  2022cites this paper
• Comparative Assessment of the Antioxidant and Anticancer Activities of Plicosepalus acacia and Plicosepalus curviflorus: Metabolomic Profiling and In Silico Studies

  2022cites this paper
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  2022cites this paper
• Ursolic Acid Inhibits Collective Cell Migration and Promotes JNK-Dependent Lysosomal Associated Cell Death in Glioblastoma Multiforme Cells

  2021cites this paper
• Role of Pentacyclic Triterpenoid Acids in the Treatment of Bladder Cancer.

  2021cites this paper
• Ursolic Acid and Related Analogues: Triterpenoids with Broad Health Benefits

  2021cites this paper
• Perspectives on natural compounds in chemoprevention and treatment of cancer: an update with new promising compounds.

  2021cites this paper
• Ursolic acid inhibits cell migration and promotes JNK-dependent lysosomal associated cell death in Glioblastoma multiforme cells

  2020cites this paper
• Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets

  2020cites this paper
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  2020cites this paper
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  2019cites this paper
• Cranberry as a Promising Natural Source of Potential Nutraceuticals with Anticancer Activity.

  2019cites this paper
• Highlights of Natural Products in Prostate Cancer Drug Discovery

  2019cites this paper
• Ursolic and Oleanolic Acids Induce Mitophagy in A549 Human Lung Cancer Cells

  2019cites this paper
• A novel antimicrobial peptide, Ranatuerin-2PLx, showing therapeutic potential in inhibiting proliferation of cancer cells

  2018cites this paper
• Ursolic acid elicits intrinsic apoptotic machinery by downregulating the phosphorylation of AKT/BAD signaling in human cisplatin‑resistant oral cancer CAR cells.

  2018cites this paper
• Recent progress in natural dietary non-phenolic bioactives on cancers metastasis

  2018cites this paper
• 21 Highlights of Natural Products in Prostate Cancer Drug Discovery

  2018cites this paper
• Epigenetic regulation of Nrf2 and ursolic acid in skin carcinogenesis

  2018cites this paper
• Ursolic Acid Promotes the Sensitization of rhTRAIL-resistant Triple-negative Breast Cancer

  2018cites this paper
• Interference of ursolic acid treatment with glioma growth: An in vitro and in vivo study.

  2017cites this paper
• Ursolic acid inhibits breast cancer growth by inhibiting proliferation, inducing autophagy and apoptosis, and suppressing inflammatory responses via the PI3K/AKT and NF-κB signaling pathways in vitro

  2017cites this paper
• Effects of Chinese Medicine as Adjunct Medication for Adjuvant Chemotherapy Treatments of Non-Small Cell Lung Cancer Patients

  2017cites this paper
• Modulation of Tumour-Related Signaling Pathways by Natural Pentacyclic Triterpenoids and their Semisynthetic Derivatives.

  2017cites this paper
• In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention

  2017cites this paper
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  2017cites this paper
• Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment.

  2017cites this paper
• The impact of oleanolic and ursolic acid on corneal epithelial cells in vitro

  2017cites this paper
• Correction to: In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention

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• Medicinal plants of the genuses Salvia and Hypericum are sources of anticolon cancer compounds: Effects on PI3K/Akt and MAP kinases pathways

  2016cites this paper
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  2016cites this paper
• Chapter 4 Triterpenoids and Sesquiterpenoids for Prostate Cancer Therapy

  2016cites this paper
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  2016cites this paper
• Preparation and Pre-clinical Evaluation of New Pentacyclic Triterpenoids

  2016cites this paper
• Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells.

  2016cites this paper
• Triterpenes with healing activity: A systematic review

  2015cites this paper
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  2015cites this paper
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  2013cites this paper
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  2013cites this paper
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