Temporal dynamics of nutrient balance, plasma biochemical and immune traits, and liver function in transition dairy cows

Abstract The objective of this study was to analyze the dynamics of nutrient balance, physiological biomarkers and comprehensive indexes associated with metabolism and function of organs in transition cows. Fourteen transition cows were used for this research. Dietary intake was recorded daily, and samples of the diet, venous blood and milk were collected for measurements. The balance values of net energy for lactation (NEL), metabolizable protein (MP), and metabolizable glucose (MG) were calculated, and regression analysis and calculation of comprehensive indexes were performed. Accordingly, the prepartum cows presented positive balances of NEL, MP, and MG, while severe negative balances were found during the postpartum period. Dynamic changes of energy metabolism, nutrient mobilization, liver function, anti-oxidative status and immune response, as indicated by blood biomarkers and modified comprehensive indexes, were out of sync with the calculated balance values, but they were closely related to the day relative to calving. Compared with the 21 d prepartum, the plasma concentrations of non-esterified fatty acids (NEFA) and β-hydroxybutyric acid (BHBA) were significantly increased around and after calving (P

• Publication year

  2020

• Venue

  Journal of Integrative Agriculture

• Publication date

  2020-03-01

• Fields of study

  Agricultural and Food Sciences, Biology

• Identifiers
  DOI 10.1016/s2095-3119(20)63153-7
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Orthogonal comparisons

  2022cited by this paper
• Choline and methionine regulate lipid metabolism via the AMPK signaling pathway in hepatocytes exposed to high concentrations of nonesterified fatty acids

  2020cited by this paper
• The association of plasma glucose, BHBA, and NEFA with postpartum uterine diseases, fertility, and milk production of Holstein dairy cows.

  2017cited by this paper
• Nutritional strategies to optimize dairy cattle immunity.

  2016cited by this paper
• Effects of slow-release urea and rumen-protected methionine and histidine on mammalian target of rapamycin (mTOR) signaling and ubiquitin proteasome-related gene expression in skeletal muscle of dairy cows.

  2016cited by this paper
• Rumen-protected methionine compared with rumen-protected choline improves immunometabolic status in dairy cows during the peripartal period.

  2016cited by this paper
• Regulation of Nutritional Metabolism in Transition Dairy Cows: Energy Homeostasis and Health in Response to Post-Ruminal Choline and Methionine

  2016cited by this paper
• β-Hydroxybutyrate induces bovine hepatocyte apoptosis via an ROS-p38 signaling pathway.

  2016cited by this paper
• Circulating amino acids in blood plasma during the peripartal period in dairy cows with different liver functionality index.

  2016cited by this paper
• The role of rumen-protected choline in hepatic function and performance of transition dairy cows

  2016cited by this paper
• Better postpartal performance in dairy cows supplemented with rumen-protected methionine compared with choline during the peripartal period.

  2016cited by this paper
• Short communication: Regulation of hepatic gluconeogenic enzymes by dietary glycerol in transition dairy cows.

  2016cited by this paper
• Effects of Long-Term Mineral Block Supplementation on Antioxidants, Immunity, and Health of Tibetan Sheep

  2016cited by this paper
• 1,25-Dihydroxyvitamin D3 modulates calcium transport in goat mammary epithelial cells in a dose- and energy-dependent manner

  2016cited by this paper
• Evaluation of propylene glycol and glycerol infusions as treatments for ketosis in dairy cows.

  2015cited by this paper
• Plasma ceramides are elevated in overweight Holstein dairy cows experiencing greater lipolysis and insulin resistance during the transition from late pregnancy to early lactation.

  2015cited by this paper
• Nutrition, rumen health and inflammation in the transition period and their role on overall health and fertility in dairy cows.

  2015cited by this paper
• Effects of rumen-protected choline supplementation on metabolic and performance responses of transition dairy cows.

  2015cited by this paper
• NEFAs Activate the Oxidative Stress‐mediated NF‐κB Signaling Pathway to Induce Inflammatory Response in Calf Hepatocytes

  2015cited by this paper
• Effects of slow-release urea and rumen-protected methionine and histidine on performance of dairy cows.

  2015cited by this paper
• Endocrine and metabolic mechanisms linking postpartum glucose with early embryonic and foetal development in dairy cows.

  2014cited by this paper
• Transition cow nutrition and feeding management for disease prevention.

  2014cited by this paper
• Biomarkers of inflammation, metabolism, and oxidative stress in blood, liver, and milk reveal a better immunometabolic status in peripartal cows supplemented with Smartamine M or MetaSmart.

  2014cited by this paper
• Systems nutrition: an innovation of a scientific system in animal nutrition.

  2014cited by this paper
• Associations of cytological endometritis with energy metabolism and inflammation during the periparturient period and early lactation in dairy cows.

  2014cited by this paper
• Estimación lineal de los requerimientos nutricionales del NRC para ganado de leche.

  2014cited by this paper
• Significance of metabolic stress, lipid mobilization, and inflammation on transition cow disorders.

  2013cited by this paper
• TNFα Altered Inflammatory Responses, Impaired Health and Productivity, but Did Not Affect Glucose or Lipid Metabolism in Early-Lactation Dairy Cows

  2013cited by this paper
• Relation of inflammation and liver function with the plasma cortisol response to adrenocorticotropin in early lactating dairy cows.

  2013cited by this paper
• Use of the liver activity index and other metabolic variables in the assessment of metabolic health in dairy herds.

  2013cited by this paper
• Precursors for liver gluconeogenesis in periparturient dairy cows.

  2013cited by this paper
• Supplemental Smartamine M or MetaSmart during the transition period benefits postpartal cow performance and blood neutrophil function.

  2013cited by this paper
• Effect of rumen-protected choline supplementation on liver and adipose gene expression during the transition period in dairy cattle.

  2013cited by this paper
• Assessing and managing body condition score for the prevention of metabolic disease in dairy cows.

  2013cited by this paper
• Effects of rumen-protected γ-aminobutyric acid on feed intake, lactation performance, and antioxidative status in early lactating dairy cows.

  2013cited by this paper
• Functional welfare-using biochemical and molecular technologies to understand better the welfare state of peripartal dairy cattle

  2013cited by this paper
• Nutritional management of the transition cow in the 21st century – a paradigm shift in thinking

  2013cited by this paper
• Metabolic and endocrine profiles of primiparous beef cows grazing native grassland. 1. Relationships between body condition score at calving and metabolic profiles during the transition period

  2013cited by this paper
• Negative Protein Balance: Implications for Fresh and Transition Cows

  2013cited by this paper
• Effect of leptin on the gluconeogenesis in calf hepatocytes cultured in vitro

  2013cited by this paper
• Metabolic stress and inflammatory response in high-yielding, periparturient dairy cows.

  2012cited by this paper
• Protein and fat mobilization and associations with serum β-hydroxybutyrate concentrations in dairy cows.

  2012cited by this paper
• Effect of prepartum maternal energy density on the growth performance, immunity, and antioxidation capability of neonatal calves.

  2012cited by this paper
• Effect of rumen-protected choline on performance, blood metabolites, and hepatic triacylglycerols of periparturient dairy cattle.

  2011cited by this paper
• An additional study on the relationship between the inflammatory condition at calving time and net Energy efficiency in dairy cows

  2010cited by this paper
• Effects of dietary energy and protein density on plasma concentrations of leptin and metabolic hormones in dairy heifers.

  2009cited by this paper
• Leptin intake during lactation prevents obesity and affects food intake and food preferences in later life.

  2009cited by this paper
• Effects of peripartum propylene glycol supplementation on nitrogen metabolism, body composition, and gene expression for the major protein degradation pathways in skeletal muscle in dairy cows.

  2008cited by this paper
• Nutritional and management strategies for the prevention of fatty liver in dairy cattle.

  2008cited by this paper
• Effects of inflammatory conditions on liver activity in puerperium period and consequences for performance in dairy cows.

  2008cited by this paper
• Production diseases of the transition cow.

  2008cited by this paper
• Effects of fasting on the meat quality and antioxidant defenses of market-size farmed large yellow croaker (Pseudosciaena crocea)

  2008cited by this paper
• Relationships among milk production, energy balance, plasma analytes, and reproduction in Holstein-Friesian cows.

  2007cited by this paper
• Influence of negative energy balance on cyclicity and fertility in the high producing dairy cow.

  2007cited by this paper
• Plasma paraoxonase, health, inflammatory conditions, and liver function in transition dairy cows.

  2007cited by this paper
• Dietary energy source in dairy cows in early lactation: energy partitioning and milk composition.

  2007cited by this paper
• Oxidants and antioxidants in disease: oxidative stress in farm animals.

  2007cited by this paper
• Regulatory roles of leptin in reproduction and metabolism: a comparative review.

  2005cited by this paper
• Nutritional Management of Transition Dairy Cows: Strategies to Optimize Metabolic Health

  2004cited by this paper
• Feeding glycerol to transition dairy cows: effects on blood metabolites and lactation performance.

  2004cited by this paper
• Leptin concentrations in relation to energy balance, milk yield, intake, live weight, and estrus in dairy cows.

  2003cited by this paper
• Markers of oxidative status in plasma and erythrocytes of transition dairy cows during hot season.

  2002cited by this paper
• T-cell development and the CD4–CD8 lineage decision

  2002cited by this paper
• Incorporation of the fasting plasma FFA concentration into QUICKI improves its association with insulin sensitivity in nonobese individuals.

  2001cited by this paper
• Adaptations of Glucose and Long-Chain Fatty Acid Metabolism in Liver of Dairy Cows during the Periparturient Period

  2001cited by this paper
• Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance.

  2001cited by this paper
• Protein nutrition in late pregnancy, maternal protein reserves and lactation performance in dairy cows

  2000cited by this paper
• Neuropeptide Y restores appetite and alters concentrations of GH after central administration to endotoxic sheep.

  1999cited by this paper
• Factors affecting body tissue mobilization in early lactation dairy cows. 2. Effect of dietary fat on mobilization of body fat and protein.

  1998cited by this paper
• Factors affecting body tissue mobilization in early lactation dairy cows. 1. Effect of dietary protein on mobilization of body fat and protein.

  1997cited by this paper
• Adaptations of Glucose Metabolism During Pregnancy and Lactation

  1997cited by this paper
• State-of-the-art of high-performance liquid chromatographic analysis of amino acids in physiological samples.

  1996cited by this paper
• Impact of changes in organic nutrient metabolism on feeding the transition dairy cow.

  1995cited by this paper
• A sensitive and reliable method for assaying true human insulin without interaction with human proinsulin-like molecules

  1995cited by this paper
• Etiology of lipid-related metabolic disorders in periparturient dairy cows.

  1993cited by this paper
• Diet selection in sheep: the ability of growing lambs to select a diet that meets their crude protein (nitrogen × 6.25) requirements

  1993cited by this paper
• Effect of prepartum dry matter intake on liver triglyceride concentration and early lactation.

  1992cited by this paper
• Revisiting and revising suppressor T cells.

  1992cited by this paper
• Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition.

  1991cited by this paper
• Duncan Multiple Range Test

  1987cited by this paper
• Official Methods of Analysis

  1980cited by this paper

• AMPKα alleviates the inhibitory effect of NEFA on the function of bovine follicular granulosa cells cultured in vitro.

  2025cites this paper
• Sodium propionate supplementation improves the negative energy balance in postpartum dairy cattle through regulation of glycolipid metabolism

  2025cites this paper
• Index Development to Comprehensive Assess Liver Function during the Dairy Cows’ Transition Period in Low-Tropic Conditions

  2024cites this paper
• Relationship between rumen microbiota and pregnancy toxemia in ewes

  2024cites this paper
• Propylthiouracil thyroid manipulation positively affects the metabolic adaptability of primiparous dairy cows to early lactation requirements

  2024cites this paper
• Dietary β-hydroxybutyrate sodium alters rumen microbiome and nutrient metabolism in the rumen epithelium of young goats

  2024cites this paper
• Medium chain fatty acid supplementation improves animal metabolic and immune status during the transition period: A study on dairy cattle

  2023cites this paper
• The Impact of Dietary Berberine Supplementation during the Transition Period on Blood Parameters, Antioxidant Indicators and Fatty Acids Profile in Colostrum and Milk of Dairy Goats

  2022influential citation
• SOME BLOOD METABOLIC PARAMRTERS AND BODY WEIGHT OF REPLACEMENT FRIESIAN HEIFERS TREATED WITH SOME ENERGY SOURCES

  2022cites this paper
• One-carbon, carnitine, and glutathione metabolism-related biomarkers in peripartal Holstein cows are altered by prepartal body condition.

  2021cites this paper
• Regulation of Nutritional Metabolism in Transition Dairy Goats: Energy Balance, Liver Activity, and Insulin Resistance in Response to Berberine Supplementation

  2021cites this paper
• Effects of Propylene Glycol on Negative Energy Balance of Postpartum Dairy Cows

  2020influential citation