SCIENCE@home

Computational systems mechanobiology of growth and remodeling: Integration of tissue mechanics and cell regulatory network dynamics

V. Sree,A. B. Tepole

Published 2020 in Current Opinion in Biomedical Engineering

ABSTRACT

Abstract Growth and remodeling (G&R) of biological tissues is an inherently multiscale and multiphysics process. In the past two decades, computational models of G&R have been developed to improve our fundamental understanding of how tissues adapt to mechanical cues. Models focused on tissue mechanics have successfully captured G&R of tissues but lacking a detailed description of the biological control at the cell level. In contrast, systems biology models of mechanotransduction and cellular processes associated to G&R events have been developed often without coupling to the tissue mechanical behavior at multiple scales. Here, we review novel approaches to fuse the systems biology approach to cell mechanobiology with the continuum mechanics descriptions of G&R.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-41 of 41 references · Page 1 of 1

CITED BY

Showing 1-14 of 14 citing papers · Page 1 of 1