3D Imaging and Morphometry of the Coronary Microcirculation in Spontaneously Hypertensive Rats and Normotensive Controls

C. Olianti,F. Giardini,Erica Lazzeri,I. Costantini,C. Crocini,L. Bocchi,F. Pavone,P. Camici,L. Sacconi

Published 2020 in Biophysical Journal

ABSTRACT

Several causes, both genetic and environmental, can lead to development and progression of arterial hypertension. Up to date, our knowledge on vasculature remodeling associated with arterial hypertension is based on non-integrated information commonly obtained with low spatial resolution methods. Here, we investigate the coronary microcirculation by developing a protocol to perform high-resolution 3D structural reconstruction to define the role of its anatomical remodeling in the context of hypertension.

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