Design and implementation of low-cost linear laser scanning system for photoacoustic imaging

Photoacoustic imaging is a hybrid imaging technique with broad preclinical and clinical applications. Most of the optical-resolution photoacoustic microscopy (PAM) configurations are based on 3D scanning motor to scan the transducer together with the imaged sample or utilizing galvanometer scanning mirrors. In this paper, a novel low-cost linear laser scanning (LLS) system for photoacoustic microscopy is presented. The linear laser scanning system performs the two-dimensional scanning of the beam across a focusing lens. The prototype built for LLS system features a precision machined aluminum base with mounting platforms for optical components to insure proper alignment through the imaging process. The LLS relies on two stepper motors (1.8-degree, 200 steps per revolution) separately actuated, to move two 45-degree mirror mounts set onto high precision linear slides (44.5 mm of travel) which allow the laser beam to be moved across a tissue sample in a 2D axis. The threaded rod which is used to connect the linear slides and mirror assemblies has a travel distance per turn of 1/20.8” meaning for every inch of travel the rod must turn 20.8 times. The mechanical resolution of the system was estimated to be 6 μm. In this system, a pulsed laser diode with a wavelength of peak radiant intensity of 905 nm and output peak power of 220 W with 50 ns pulse width and repetition rate of 10 kHz was utilized as a light source.

• Publication year

  2020

• Venue

  BiOS

• Publication date

  2020-02-17

• Fields of study

  Materials Science, Medicine, Physics, Engineering

• Identifiers
  DOI 10.1117/12.2547221
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Laser scanning laser diode photoacoustic microscopy system

  2017cited by this paper
• Improvement and evaluation of a low-cost laser diode photoacoustic microscopy system for ovarian tissue imaging

  2016cited by this paper
• A compact and cost-efficient photoacoustic microscopy system with a pulsed laser diode excitation

  2015cited by this paper
• Wavelength optimization for in vivo multispectral photoacoustic/ultrasound tomography of hemoglobin oxygenation in ovarian cancer: clinical studies

  2015cited by this paper
• Design of optimal light delivery system for co-registered transvaginal ultrasound and photoacoustic imaging of ovarian tissue

  2015cited by this paper
• A low-cost photoacoustic microscopy system with a laser diode excitation.

  2014cited by this paper
• Design of miniaturized illumination for transvaginal co-registered photoacoustic and ultrasound imaging.

  2014cited by this paper
• Photoimprint photoacoustic microscopy for three-dimensional label-free subdiffraction imaging.

  2014cited by this paper
• Photoacoustic microscopy

  2013cited by this paper
• Optical-resolution photoacoustic microscopy: auscultation of biological systems at the cellular level.

  2013cited by this paper
• Optical coherence photoacoustic microscopy: accomplishing optical coherence tomography and photoacoustic microscopy with a single light source.

  2012cited by this paper
• Reflection-mode submicron-resolution in vivo photoacoustic microscopy.

  2012cited by this paper
• Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs

  2012cited by this paper
• In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy.

  2012cited by this paper
• Miniaturized all-optical photoacoustic microscopy based on microelectromechanical systems mirror scanning.

  2012cited by this paper
• Quantitative photoacoustic microscopy of optical absorption coefficients from acoustic spectra in the optical diffusive regime.

  2012cited by this paper
• Real-time handheld optical-resolution photoacoustic microscopy.

  2011cited by this paper
• Second generation optical-resolution photoacoustic microscopy

  2011cited by this paper
• Fast voice-coil scanning optical-resolution photoacoustic microscopy.

  2011cited by this paper
• Hybrid-scanning optical-resolution photoacoustic microscopy for in vivo vasculature imaging.

  2010cited by this paper
• Laser optoacoustic imaging system for detection of breast cancer.

  2009cited by this paper
• Multiscale photoacoustic microscopy and computed tomography.

  2009cited by this paper
• Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries.

  2008cited by this paper
• Photoacoustic imaging of biological tissue with intensity-modulated continuous-wave laser.

  2008cited by this paper
• Realtime photoacoustic microscopy in vivo with a 30-MHz ultrasound array transducer.

  2008cited by this paper
• Spectroscopic intravascular photoacoustic imaging to differentiate atherosclerotic plaques.

  2008cited by this paper
• Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging

  2006cited by this paper
• Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain

  2003cited by this paper
• Thermoacoustic computed tomography using a conventional linear transducer array.

  2003cited by this paper
• Backward mode detection of laser-induced wide-band ultrasonic transients with optoacoustic transducer

  2000cited by this paper

• No citing papers are available for this paper.