Central Pontine Myelinolysis

Central pontine myelinolysis (CPM) is a component of osmotic demyelination syndrome (ODS). It is characterized by damage to regions of the brain, most commonly pontine white matter tracts, after rapid correction of metabolic disturbances such as hyponatremia. Central pontine myelinolysis (CPM) was first described in 1959 by Adams and his colleagues in a report of four patients with pseudobulbar palsy and quadriplegia. The initial cases were seen in patients with alcohol use disorder and malnutrition; however, by the 1970s, subsequent cases showed a link with rapid sodium correction. CPM has since been reported in cases of severe burns, liver transplantation, anorexia nervosa and hyperemesis gravidarum, and hyperglycemic states. Clinical features of CPM typically begin to appear within several days after rapid correction of hyponatremia. Clinical manifestations vary and can range from encephalopathy to coma and death.

• Publication year

  2019

• Venue

  Definitions

• Publication date

  2019-11-11

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/B978-0-323-44549-8.00006-7
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

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• No concepts are published for this paper.

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• Central pontine and extrapontine myelinolysis: a systematic review

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• Osmotic demyelination syndrome: central pontine myelinolysis and extrapontine myelinolysis.

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• Movement disorders and the osmotic demyelination syndrome

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• Hypertonic saline and desmopressin: a simple strategy for safe correction of severe hyponatremia.

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• Management of hyponatremia in the ICU.

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• Clinical and radiologic correlations of central pontine myelinolysis syndrome.

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• DDAVP is effective in preventing and reversing inadvertent overcorrection of hyponatremia.

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• AJR teaching file: symmetric demyelination.

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• Outcome of central pontine and extrapontine myelinolysis (n = 44)

  1999cited by this paper
• Treatment of central pontine myelinolysis with therapeutic plasmapheresis.

  1999cited by this paper
• Myelinolysis after Correction of Hyponatremia

  1997cited by this paper
• Temporal changes of MR findings in central pontine myelinolysis.

  1995cited by this paper
• Neurologic sequelae after treatment of severe hyponatremia: a multicenter perspective.

  1994cited by this paper
• Central pontine myelinolysis after liver transplantation

  1989cited by this paper
• Central pontine myelinolysis. Two cases with associated electrolyte disturbance.

  1976cited by this paper
• NEUROLOGICAL MANIFESTATIONS AND MORBIDITY OF HYPONATREMIA: CORRELATION WITH BRAIN WATER AND ELECTROLYTES

  1976cited by this paper
• Central Pontine Myelinolysis: A Hitherto Undescribed Disease Occurring in Alcoholic and Malnourished Patients

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