Mechanism of inhibition of wt‐dihydrofolate reductase from E. coli by tea epigallocatechin‐gallate

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Proteins: Structure, Function, and Bioinformatics

• Publication date

  2008-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1002/prot.21914PMID 18214969
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study.

  2006cited by this paper
• Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid

  2006cited by this paper
• Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications.

  2006cited by this paper
• Interaction of (−)‐epigallocatechin‐3‐gallate with human serum albumin: Fluorescence, fourier transform infrared, circular dichroism, and docking studies

  2006cited by this paper
• Bisubstrate inhibition: Theory and application to N-acetyltransferases.

  2006cited by this paper
• The behavior and significance of slow-binding enzyme inhibitors.

  2006cited by this paper
• Flavonoids inhibit the amidolytic activity of human thrombin.

  2006cited by this paper
• Flavonoid diversity and biosynthesis in seed of Arabidopsis thaliana

  2006cited by this paper
• The antifolate activity of tea catechins.

  2005cited by this paper
• Mechanisms for the Inhibition of DNA Methyltransferases by Tea Catechins and Bioflavonoids

  2005cited by this paper
• The antifolate activity of tea catechins.

  2005cited by this paper
• Peroxynitrite-mediated oxidation of the C85S/C152E mutant of dihydrofolate reductase from Escherichia coli: functional and structural effects.

  2005cited by this paper
• Kinetics of the inhibition of bovine liver dihydrofolate reductase by tea catechins: origin of slow-binding inhibition and pH studies.

  2005cited by this paper
• The Intermediate Filament Protein Vimentin Is a New Target for Epigallocatechin Gallate*

  2005cited by this paper
• Searching Sequence Space: Two Different Approaches to Dihydrofolate Reductase Catalysis

  2005cited by this paper
• Chemotherapy and the war on cancer

  2005cited by this paper
• Temperature dependence of the thrombin-catalyzed proteolysis of prothrombin.

  2004cited by this paper
• Flavonoid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. postulation of a biosynthetic pathway.

  2004cited by this paper
• Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry.

  2004cited by this paper
• Specific interactions of quercetin and other flavonoids with target proteins are revealed by elicited fluorescence.

  2004cited by this paper
• Protective effect of green tea against prostate cancer: A case‐control study in southeast China

  2004cited by this paper
• Structure, dynamics, and catalytic function of dihydrofolate reductase.

  2004cited by this paper
• Activation of flavonoid biosynthesis by solar radiation in bilberry (Vaccinium myrtillus L.) leaves

  2004cited by this paper
• Polyphenols: food sources and bioavailability.

  2004cited by this paper
• Thermal unfolding molecular dynamics simulation of Escherichia coli dihydrofolate reductase: Thermal stability of protein domains and unfolding pathway

  2002cited by this paper
• Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress.

  2001cited by this paper
• Green tea: biochemical and biological basis for health benefits.

  2001cited by this paper
• Inhibition of tumour invasion and angiogenesis by epigallocatechin gallate (EGCG), a major component of green tea

  2001cited by this paper
• The Protein Data Bank

  2000cited by this paper
• Strength of an interloop hydrogen bond determines the kinetic pathway in catalysis by Escherichia coli dihydrofolate reductase.

  1998influential reference
• Stretching exercises--flexibility in dihydrofolate reductase catalysis.

  1998cited by this paper
• Human placenta cytidine deaminase: proton‐linked enzyme activity and substrate binding

  1997cited by this paper
• Use of a resonant mirror biosensor to characterize the interaction of carboxypeptidase A with an elicited monoclonal antibody.

  1997cited by this paper
• Specificity in structure‐based drug design: Identification of a novel, selective inhibitor of Pneumocystis carinii dihydrofolate reductase

  1997cited by this paper
• Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence.

  1997cited by this paper
• A strategy for testing the suitability of cysteine replacements in dihydrofolate reductase from Escherichia coli.

  1995cited by this paper
• Thermodynamic study of dihydrofolate reductase inhibitor selectivity.

  1994cited by this paper
• The Resonant Mirror: A Versatile Tool for the Study of Biomolecular Interactions

  1994cited by this paper
• Critical role of phenylalanine 34 of human dihydrofolate reductase in substrate and inhibitor binding and in catalysis.

  1994cited by this paper
• Global analysis of biochemical and biophysical data.

  1992cited by this paper
• Human dihydrofolate reductase: reduction of alternative substrates, pH effects, and inhibition by deazafolates.

  1992cited by this paper
• Linkage between proton binding and amidase activity in human alpha-thrombin: effect of ions and temperature.

  1991cited by this paper
• Effect of protons on the amidase activity of human α-thrombin: Analysis in terms of a general linkage scheme

  1990cited by this paper
• Effect of protons on the amidase activity of human alpha-thrombin. Analysis in terms of a general linkage scheme.

  1990cited by this paper
• Binding and Linkage: Functional Chemistry of Biological Macromolecules

  1990cited by this paper
• Analysis and parameter resolution in highly cooperative systems.

  1988cited by this paper
• Folding of dihydrofolate reductase from Escherichia coli

  1986cited by this paper
• Folding of dihydrofolate reductase from Escherichia coli.

  1986cited by this paper
• Mechanism of inhibition of dihydrofolate reductases from bacterial and vertebrate sources by various classes of folate analogues.

  1986cited by this paper
• [16] Nonlinear least-squares analysis

  1985cited by this paper
• Dihydrofolate reductase. The stereochemistry of inhibitor selectivity.

  1985cited by this paper
• Enzyme kinetics: Behavior and analysis of rapid equilibrium and steady‐state enzyme systems. Author: Irwin H. Segal (University of California, Davis). Published by Wiley‐Interscience, New York, 1975. Price: $24.50. No. of pages: 957

  1976cited by this paper
• Effect of substrate decomposition on the spectrophotometric assay of dihydrofolate reductase.

  1967cited by this paper
• Electronic Reprint Biological Crystallography the Protein Data Bank Biological Crystallography the Protein Data Bank

  year unknowncited by this paper

• Microbiome-generated antifolates.

  2026cites this paper
• Exploring the Potential of Thiazolo[5,4‐ c ]Isoquinoline Derivatives as Dihydrofolate Reductase Inhibitors: Insights from Molecular Docking and Experimental Studies for Antibacterial Therapy

  2025cites this paper
• A silent sulfonamide-resistant microbial world: the curious case of missing DHPS in candidate phyla radiation.

  2025cites this paper
• Dietary flavonoids in health and diseases: A concise review of their role in homeostasis and therapeutics.

  2025cites this paper
• Green Tea Polyphenols in Wound Healing: Therapeutic Mechanisms, Potential Applications and Challenges in Commercial Use for Diabetic Wound Healing

  2025cites this paper
• Insight into the Phenolic Composition of Cabernet Sauvignon Grapevine Berries During Fermentation—Towards the Application of Winery By-Products for Antibacterial Purposes

  2025cites this paper
• Potential of plants-based alkaloids, terpenoids and flavonoids as antibacterial agents: An update

  2025cites this paper
• Exploring Antimicrobial Compounds from Agri-Food Wastes for Sustainable Applications

  2024cites this paper
• The potential of EGCG in modulating the oral-gut axis microbiota for treating inflammatory bowel disease.

  2024cites this paper
• PEGylation of Chrysin Improves Its Water Solubility while Preserving the In Vitro Biological Activity.

  2023cites this paper
• Interactions between gut microbiota and polyphenols: A mechanistic and metabolomic review.

  2023cites this paper
• Natural bioactive compounds from medicinal plants as antibacterial drugs: mechanism insights and clinical perspectives.

  2022cites this paper
• Mechanisms, Anti-Quorum-Sensing Actions, and Clinical Trials of Medicinal Plant Bioactive Compounds against Bacteria: A Comprehensive Review

  2022cites this paper
• Anti‐microbial efficacy, mechanisms and druggability evaluation of the natural flavonoids

  2022cites this paper
• Health promoting activities and corresponding mechanism of (–)-epicatechin-3-gallate

  2022cites this paper
• EGCG Induces Pro-inflammatory Response in Macrophages to Prevent Bacterial Infection through the 67LR/p38/JNK Signaling Pathway.

  2021cites this paper
• Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid–Base Catalysis

  2021cites this paper
• Antibacterial green tea catechins from a molecular perspective: mechanisms of action and structure-activity relationships.

  2020cites this paper
• Tea bioactive components prevent carcinogenesis via anti‐pathogen, anti‐inflammation, and cell survival pathways

  2020cites this paper
• Acetylshikonin isolated from Lithospermum erythrorhizon roots inhibits dihydrofolate reductase and hampers autochthonous mammary carcinogenesis in Δ16HER2 transgenic mice.

  2020cites this paper
• Antimicrobial flavonoids as a potential substitute for overcoming antimicrobial resistance.

  2020cites this paper
• Flavonoids for Therapeutic Applications

  2020cites this paper
• Structural and chemical changes of grape seed extract after thermal processing and its use in rainbow trout (Oncorhynchus mykiss) diets as an organic feed supplement

  2019cites this paper
• Inhibition of Virulence-Related Traits in Pseudomonas syringae pv. actinidiae by Gunpowder Green Tea Extracts

  2019cites this paper
• Green Tea Catechins: Their Use in Treating and Preventing Infectious Diseases

  2018cites this paper
• Comprehensive review of antimicrobial activities of plant flavonoids

  2018cites this paper
• Les polyphénols du thé vert : des molécules à double action contre la maladie parodontale

  2015cites this paper
• Combined Effects of Curcumin and (-)-Epigallocatechin Gallate on Inhibition of N-Acylhomoserine Lactone-Mediated Biofilm Formation in Wastewater Bacteria from Membrane Bioreactor.

  2015cites this paper
• Potentials of nutritional therapy, phytopharmaceuticals and phytomedicine in the prevention and control of Ebola virus in Africa

  2015cites this paper
• The Lactone form of stachybotrydial: a new inhibitor of dihydrofolate reductase from stachybotrys sp. FN298.

  2014cites this paper
• Modulation de l'expression de gènes reliés à la virulence et au stress chez Porphyromonas gingivalis par les polyphénols du thé vert

  2014cites this paper
• Targeting the epigenetic machinery of cancer cells

  2014cites this paper
• Novel phytochemical–antibiotic conjugates as multitarget inhibitors of Pseudomononas aeruginosa GyrB/ParE and DHFR

  2013cites this paper
• Anti‐infective properties of epigallocatechin‐3‐gallate (EGCG), a component of green tea

  2013cites this paper
• Factors Influencing the Antifolate Activity of Synthetic Tea-Derived Catechins

  2013cites this paper
• Sanguisorba minor extract suppresses plasmin-mediated mechanisms of cancer cell migration.

  2012cites this paper
• Novel Antifolates as Produgs for the Treatment of Melanoma

  2011cites this paper
• Identification of an EGCG oxidation derivative with proteasome modulatory activity.

  2011cites this paper
• Insights into antifolate activity of phytochemicals against Pseudomonas aeruginosa

  2011cites this paper
• Epigallocatechin-3-gallate potently inhibits the in vitro activity of hydroxy-3-methyl-glutaryl-CoA reductase[S]

  2011cites this paper
• Comparison of a Pair of Synthetic Tea‐Catechin‐Derived Epimers: Synthesis, Antifolate Activity, and Tyrosinase‐Mediated Activation in Melanoma

  2011cites this paper
• Melanoma activation of 3-o-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin to a potent irreversible inhibitor of dihydrofolate reductase.

  2009cites this paper
• Influence of dietary feeding of low monomer content grape seed extract on vitellogenin production and cholesterol levels in goldfish, Carassius auratus.

  2009cites this paper
• Homology Modeling and Docking Analysis of the Interaction between Polyphenols and Mammalian 20S Proteasomes

  2009cites this paper
• Grading the commercial optical biosensor literature—Class of 2008: ‘The Mighty Binders’

  2009cites this paper