The p110delta isoform of PI3K differentially regulates beta1 and beta2 integrin-mediated monocyte adhesion and spreading and modulates diapedesis.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Microcirculation

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 16864411
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interleukin‐1β Reduces Transcellular Monocyte Diapedesis and Compromises Endothelial Adherens Junction Integrity

  2005cited by this paper
• Integrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch*

  2005cited by this paper
• Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines

  2005cited by this paper
• Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia.

  2005cited by this paper
• Mechanisms and implications of phosphoinositide 3-kinase delta in promoting neutrophil trafficking into inflamed tissue.

  2004cited by this paper
• Relative contributions of alpha4 and alphaL integrins to IL-4-induced leukocyte rolling and adhesion.

  2004cited by this paper
• Ligation of lymphocyte function-associated antigen-1 on monocytes decreases very late antigen-4-mediated adhesion through a reactive oxygen species-dependent pathway.

  2004cited by this paper
• Dual role of NF-kappaB in apoptosis of THP-1 cells during treatment with etoposide and lipopolysaccharide.

  2004cited by this paper
• Signaling through the Leukocyte Integrin LFA-1 in T Cells Induces a Transient Activation of Rac-1 That Is Regulated by Vav and PI3K/Akt-1*

  2004cited by this paper
• ARAP3 is a PI3K- and rap-regulated GAP for RhoA.

  2004cited by this paper
• Phosphoinositide 3-kinase: diverse roles in immune cell activation.

  2004cited by this paper
• Essential role for the p110delta phosphoinositide 3-kinase in the allergic response.

  2004cited by this paper
• PI3-Kinase Upregulation and Involvement in Spontaneous Tone in Arteries From DOCA-Salt Rats: Is p110&dgr; the Culprit?

  2004cited by this paper
• Phosphoinositide 3‐kinase‐dependent activation of Rac

  2003cited by this paper
• Essential Role of Phosphoinositide 3-Kinase δ in Neutrophil Directional Movement

  2003cited by this paper
• Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta.

  2003cited by this paper
• Arrest chemokines.

  2003cited by this paper
• Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2.

  2003cited by this paper
• RhoA and ROCK Promote Migration by Limiting Membrane Protrusions*

  2003cited by this paper
• Selective role of PI3K delta in neutrophil inflammatory responses.

  2003cited by this paper
• T-cell integrins: more than just sticking points

  2003cited by this paper
• Overlapping roles of endothelial selectins and vascular cell adhesion molecule-1 in immune complex-induced leukocyte recruitment in the cremasteric microvasculature.

  2003cited by this paper
• Cell Migration: Integrating Signals from Front to Back

  2003cited by this paper
• α4 Integrin Signaling Activates Phosphatidylinositol 3-Kinase and Stimulates T Cell Adhesion to Intercellular Adhesion Molecule-1 to a Similar Extent As CD3, but Induces a Distinct Rearrangement of the Actin Cytoskeleton1

  2002cited by this paper
• From rolling to arrest on blood vessels: leukocyte tap dancing on endothelial integrin ligands and chemokines at sub-second contacts.

  2002cited by this paper
• Signaling Through Integrin LFA-1 Leads to Filamentous Actin Polymerization and Remodeling, Resulting in Enhanced T Cell Adhesion1

  2002cited by this paper
• Activation of Rap1B by Gi Family Members in Platelets*

  2002cited by this paper
• Role of endothelial MCP-1 in monocyte adhesion to inflamed human endothelium under physiological flow.

  2002cited by this paper
• Leucocyte chemotaxis: Examination of mitogen‐activated protein kinase and phosphoinositide 3‐kinase activation by Monocyte Chemoattractant Proteins‐1, ‐2, ‐3 and ‐4

  2002cited by this paper
• beta1 and beta2 integrins activate different signalling pathways in monocytes.

  2002cited by this paper
• New Responsibilities for the PI3K Regulatory Subunit p85α

  2001cited by this paper
• RhoA is required for monocyte tail retraction during transendothelial migration

  2001cited by this paper
• Leukocyte recruitment in the microcirculation: the rolling paradigm revisited.

  2001cited by this paper
• Phosphoinositide 3-kinase modulation of beta(3)-integrin represents an endogenous "braking" mechanism during neutrophil transmatrix migration.

  2001cited by this paper
• The Role of CD47 in Neutrophil Transmigration

  2001cited by this paper
• Rho proteins, PI 3‐kinases, and monocyte/macrophage motility

  2001cited by this paper
• Synthesis and function of 3-phosphorylated inositol lipids.

  2001cited by this paper
• Rho GTPases and cell migration.

  2001cited by this paper
• A major role for VCAM-1, but not ICAM-1, in early atherosclerosis.

  2001cited by this paper
• Cell adhesion assays.

  2001cited by this paper
• The affinity of integrin alpha(4)beta(1) governs lymphocyte migration.

  2001cited by this paper
• Phosphatidylinositol 3-kinase mediates integrin-dependent NF-kappaB and MAPK activation through separate signaling pathways.

  2001cited by this paper
• L-Selectin Facilitates Emigration and Extravascular Locomotion of Leukocytes During Acute Inflammatory Responses In Vivo1

  2000cited by this paper
• Inhibition of monocyte/macrophage migration to a spinal cord injury site by an antibody to the integrin alphaD: a potential new anti-inflammatory treatment.

  2000cited by this paper
• Subsecond Induction of α4 Integrin Clustering by Immobilized Chemokines Stimulates Leukocyte Tethering and Rolling on Endothelial Vascular Cell Adhesion Molecule 1 under Flow Conditions

  2000cited by this paper
• Signaling networks linking integrins and rho family GTPases.

  2000cited by this paper
• Alpha 4 beta 1 integrin/VCAM-1 interaction activates alpha L beta 2 integrin-mediated adhesion to ICAM-1 in human T cells.

  2000cited by this paper
• Effects of I domain deletion on the function of the beta2 integrin lymphocyte function-associated antigen-1.

  2000cited by this paper
• Signalling through phosphoinositide 3-kinases: the lipids take centre stage.

  1999cited by this paper
• The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function*

  1999cited by this paper
• A β1 integrin signaling pathway involving Src‐family kinases, Cbl and PI‐3 kinase is required for macrophage spreading and migration

  1998cited by this paper
• Phosphoinositide kinases.

  1998cited by this paper
• Interaction of very late antigen-4 with VCAM-1 supports transendothelial chemotaxis of monocytes by facilitating lateral migration.

  1998cited by this paper
• Phosphoinositide 3-kinases: a conserved family of signal transducers.

  1997cited by this paper
• P110delta, a novel phosphoinositide 3-kinase in leukocytes.

  1997cited by this paper
• Integrin Cross Talk: Activation of Lymphocyte Function-associated Antigen-1 on Human T Cells Alters α4β1- and α5β1-mediated Function

  1997cited by this paper
• Changes in the distribution of LFA-1, catenins, and F-actin during transendothelial migration of monocytes in culture.

  1997cited by this paper
• Signalling through the lipid products of phosphoinositide-3-OH kinase

  1997cited by this paper
• p110δ, a Novel Phosphatidylinositol 3-Kinase Catalytic Subunit That Associates with p85 and Is Expressed Predominantly in Leukocytes*

  1997cited by this paper
• Selectin-carbohydrate interactions during inflammation and metastasis

  1997cited by this paper
• Differential regulation of beta 1 and beta 2 integrin avidity by chemoattractants in eosinophils.

  1996cited by this paper
• Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm.

  1994cited by this paper
• The microcirculation and inflammation: modulation of leukocyte‐endothelial cell adhesion

  1994cited by this paper
• A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.

  1994cited by this paper
• Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.

  1994cited by this paper
• Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity.

  1991cited by this paper
• VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site.

  1990cited by this paper
• Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE.

  1990cited by this paper
• Quantification of cells cultured on 96-well plates.

  1989cited by this paper
• Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families.

  1988cited by this paper
• A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.

  1986cited by this paper
• Dualistic nature of adhesive protein function: fibronectin and its biologically active peptide fragments can autoinhibit fibronectin function

  1984cited by this paper

• Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib

  2023cites this paper
• Phosphatidylinositol 3‐Kinase δ Deficiency Protects From Antimyeloperoxidase Vasculitis

  2022cites this paper
• p55PIK Deficiency and its N-terminal Derivative inhibit Inflammation and Emphysema in COPD mouse model.

  2021cites this paper
• PI3K signalling in chronic obstructive pulmonary disease and opportunities for therapy

  2021cites this paper
• Phosphatidylinositol Kinases and in Entamoeba

  2020cites this paper
• Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica

  2019cites this paper
• PI3K signaling in chronic obstructive pulmonary disease: mechanisms, targets, and therapy.

  2019cites this paper
• Poly(ADP-ribose) polymerase inhibitor olaparib hampers placental growth factor-driven activation of myelomonocytic cells.

  2018cites this paper
• Frontline Science: Buprenorphine decreases CCL2‐mediated migration of CD14+CD16+ monocytes

  2018cites this paper
• Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation

  2018cites this paper
• Integrins in the Spotlight of Cancer

  2016cites this paper
• PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier

  2016cites this paper
• Soluble Siglec-5 associates to PSGL-1 and displays anti-inflammatory activity

  2016cites this paper
• Caractérisation de nouveaux médiateurs entre cancer, inflammation et thrombose : ADAMTS13, PSGL-1 et Siglec-5

  2016cites this paper
• Effect and possible mechanism of monocyte-derived VEGF on monocyte-endothelial cellular adhesion after electrical burns.

  2015cites this paper
• Pharmacological targeting of neutrophilic airway inflammation in COPD

  2015cites this paper
• Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: A critical role of the Notch1-NF-κB pathway in BMP-2 expression.

  2014cites this paper
• Innate immune cell migration and function in response to damage associated signals

  2014influential citation
• PI3K is involved in β1 integrin clustering by PSGL-1 and promotes β1 integrin-mediated Jurkat cell adhesion to fibronectin

  2013cites this paper
• Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier.

  2013cites this paper
• Elongated Membrane Tethers, Individually Anchored by High Affinity α4β1/VCAM-1 Complexes, Are the Quantal Units of Monocyte Arrests

  2013cites this paper
• Targeting phosphoinositide 3‐kinase δ for the treatment of respiratory diseases

  2013cites this paper
• Ezrin and Moesin Are Required for Efficient T Cell Adhesion and Homing to Lymphoid Organs

  2013cites this paper
• TLR Signaling Paralyzes Monocyte Chemotaxis through Synergized Effects of p38 MAPK and Global Rap-1 Activation

  2012cites this paper
• Mechanisms of immune response regulation by innate defense regulator peptides

  2012cites this paper
• Synthetic Immunomodulatory Peptide IDR-1002 Enhances Monocyte Migration and Adhesion on Fibronectin

  2012cites this paper
• Neurobiology Glycogen Synthase Kinase 3 Inhibition Prevents Monocyte Migration across Brain Endothelial Cells via Rac 1-GTPase Suppression and Down-Regulation of Active Integrin Conformation

  2012influential citation
• Glycogen synthase kinase 3β inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation.

  2012cites this paper
• The p110δ subunit of PI3K regulates bone marrow-derived eosinophil trafficking and airway eosinophilia in allergen-challenged mice.

  2012cites this paper
• LTB4 is a signal-relay molecule during neutrophil chemotaxis.

  2012cites this paper
• MCP-1 Induces Rapid Formation of Tethered VLA-4 Bonds with Increased Resistance to Applied Forcein THP-1 Cells

  2011cites this paper
• Overcoming Reduced Glucocorticoid Sensitivity in Airway Disease

  2010cites this paper
• PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading.

  2010cites this paper
• Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease

  2010cites this paper
• A novel MEK2/PI3Kδ pathway controls the expression of IL‐1 receptor antagonist in IFN‐β‐activated human monocytes

  2010cites this paper
• Phosphoinositide 3‐kinases in cell migration

  2009cites this paper
• Models to study atherosclerosis: a mechanistic insight.

  2009cites this paper
• In contrast to anti-tumor activity, YT cell and primary NK cell cytotoxicity for Cryptococcus neoformans bypasses LFA-1.

  2009cites this paper
• Chapter 14. Real-time in vitro assays for studying the role of chemokines in lymphocyte transendothelial migration under physiologic flow conditions.

  2009cites this paper
• Fine tuning the immune response with PI3K

  2009cites this paper
• PDK1 Regulates Chemotaxis in Human Neutrophils

  2009cites this paper
• PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP

  2008cites this paper
• Macrophages: An elusive yet emerging therapeutic target of atherosclerosis

  2008cites this paper
• Stimulatory and suppressive signal transduction regulates vasoactive intestinal peptide receptor-1 (VPAC-1) in primary mouse CD4 T cells.

  2008cites this paper
• PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils

  2008cites this paper