The sodium hydrogen exchanger 1 (NHE1)

No abstract is available for this paper.

• Publication year

  2020

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/b978-0-12-819059-3.00005-8
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Diverse residues of intracellular loop 5 of the Na+/H+ exchanger modulate proton sensing, expression, activity and targeting.

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• Elevated Na/H exchanger 1 (SLC9A1) emerges as a marker for tumorigenesis and prognosis in gliomas

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• Structure and function of yeast and fungal Na+/H+ antiporters

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• The acid-base transport proteins NHE1 and NBCn1 regulate cell cycle progression in human breast cancer cells

  2018cited by this paper
• Blockade of Na/H exchanger stimulates glioma tumor immunogenicity and enhances combinatorial TMZ and anti-PD-1 therapy

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• The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms

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• Characterizing the role of the Na+‐ H+ Exchanger Isoform 1 (NHE1) in cell proliferation and migration in ovarian cancer cells.

  2017cited by this paper
• Defining the Na+/H+ exchanger NHE1 interactome in triple-negative breast cancer cells.

  2017cited by this paper
• The Role of the Na+‐H+ Exchanger Isoform 1 (NHE1) and Calcineurin B Homologous Protein Isoform 2 (CHP2) on Cell Proliferation and Migration in Squamous Cell Carcinoma of the Lung.

  2017cited by this paper
• The Warburg Effect and the Hallmarks of Cancer.

  2017cited by this paper
• Proton channels and exchangers in cancer.

  2015cited by this paper
• A minireview on NHE1 inhibitors. A rediscovered hope in oncohematology.

  2015cited by this paper
• pH Gradient Reversal: An Emerging Hallmark of Cancers.

  2015cited by this paper
• Protease activity at invadopodial focal digestive areas is dependent on NHE1-driven acidic pHe.

  2014cited by this paper
• Cytosolic pH: A conserved regulator of cell growth?

  2014cited by this paper
• Cytosolic pH regulates cell growth through distinct GTPases, Arf1 and Gtr1, to promote Ras/PKA and TORC1 activity.

  2014cited by this paper
• The Na+ /H+ exchanger (NHE1) as a novel co-adjuvant target in paclitaxel therapy of triple-negative breast cancer cells

  2014cited by this paper
• Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question

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• Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs – an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research

  2013cited by this paper
• Sgk1-Dependent Stimulation of Cardiac Na+/H+ Exchanger Nhe1 by Dexamethasone

  2013cited by this paper
• The regulation of NHE₁ and NHE₃ activity by angiotensin II is mediated by the activation of the angiotensin II type I receptor/phospholipase C/calcium/calmodulin pathway in distal nephron cells.

  2013cited by this paper
• NaV1.5 Na+ channels allosterically regulate the NHE-1 exchanger and promote the activity of breast cancer cell invadopodia

  2013cited by this paper
• Anti-proliferative effect of atrial natriuretic peptide on colorectal cancer cells: evidence for an Akt-mediated cross-talk between NHE-1 activity and Wnt/β-catenin signaling.

  2012cited by this paper
• NHE1 mediates migration and invasion of HeLa cells via regulating the expression and localization of MT1‐MMP

  2012cited by this paper
• Na+-H+ exchanger, pH regulation and cancer.

  2012cited by this paper
• Inhibition of K562 leukemia angiogenesis and growth by selective Na+/H+ exchanger inhibitor cariporide through down-regulation of pro-angiogenesis factor VEGF.

  2011cited by this paper
• Suppression of NHE1 by small interfering RNA inhibits HIF-1α-induced angiogenesis in vitro via modulation of calpain activity.

  2011cited by this paper
• Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential

  2011cited by this paper
• In vivo key role of reactive oxygen species and NHE-1 activation in determining excessive cardiac hypertrophy

  2011cited by this paper
• Regulation of Na+/H+ Exchanger Isoform 1 (NHE1) by Calmodulin-binding Sites: Role of Angiotensin II

  2010cited by this paper
• Proton dynamics in cancer

  2010cited by this paper
• The Sodium-Hydrogen Exchanger NHE1 Is an Akt Substrate Necessary for Actin Filament Reorganization by Growth Factors*

  2009cited by this paper
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  2009cited by this paper
• NHE-1: A Molecular Target for Signalling and Cell Matrix Interactions

  2008cited by this paper
• Protein Kinase B/Akt Phosphorylates and Inhibits the Cardiac Na+/H+ Exchanger NHE1

  2008cited by this paper
• EGF upregulates Na+/H+ exchanger NHE1 by post‐translational regulation that is important for cervical cancer cell invasiveness

  2008cited by this paper
• The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells.

  2007cited by this paper
• Reduction of intracellular pH inhibits the expression of VEGF in K562 cells after targeted inhibition of the Na+/H+ exchanger.

  2007cited by this paper
• Phosphodiesterase 5A Inhibition Induces Na+/H+ Exchanger Blockade and Protection Against Myocardial Infarction

  2007cited by this paper
• Hypoxia and adaptive landscapes in the evolution of carcinogenesis

  2007cited by this paper
• Cisplatin-induced apoptosis involves membrane fluidification via inhibition of NHE1 in human colon cancer cells.

  2007cited by this paper
• Requirement of the Na + / H + Exchanger for Tumor Growth 1

  2006cited by this paper
• Reactive oxygen species-mediated regulation of the Na+–H+ exchanger 1 gene expression connects intracellular redox status with cells' sensitivity to death triggers

  2006cited by this paper
• HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes.

  2006cited by this paper
• Why bicarbonate?This paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Membrane Proteins in Health and Disease.

  2006cited by this paper
• The role of pH dynamics and the Na+/H+ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin--one single nature.

  2005cited by this paper
• Antiangiogenic Steroids in Human Cancer Therapy

  2005cited by this paper
• Na+/H+ exchanger activity is increased in doxorubicin‐resistant human colon cancer cells and its modulation modifies the sensitivity of the cells to doxorubicin

  2005cited by this paper
• Mechanisms regulating intracellular pH are activated during growth of the mouse oocyte coincident with acquisition of meiotic competence.

  2005cited by this paper
• Extracellular Zinc Triggers ERK-dependent Activation of Na+/H+ Exchange in Colonocytes Mediated by the Zinc-sensing Receptor*

  2004cited by this paper
• CD44 Interaction with Na+-H+ Exchanger (NHE1) Creates Acidic Microenvironments Leading to Hyaluronidase-2 and Cathepsin B Activation and Breast Tumor Cell Invasion*

  2004cited by this paper
• Stimulation of the Plasma Membrane Na+/H+ Exchanger NHE1 by Sustained Intracellular Acidosis

  2003cited by this paper
• Aldosterone Increases NHE-1 Expression and Induces NHE-1-Dependent Hypertrophy in Neonatal Rat Ventricular Myocytes

  2003cited by this paper
• Paclitaxel induces apoptosis via protein kinase A- and p38 mitogen-activated protein-dependent inhibition of the Na+/H+ exchanger (NHE) NHE isoform 1 in human breast cancer cells.

  2003cited by this paper
• The changing face of the Na+/H+ exchanger, NHE1: structure, regulation, and cellular actions.

  2002cited by this paper
• Carbonic Anhydrase II Binds to and Enhances Activity of the Na+/H+ Exchanger*

  2002cited by this paper
• Structure and function of the NHE1 isoform of the Na+/H+ exchanger.

  2002cited by this paper
• Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1

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• Intracellular pH homeostasis during cell-cycle progression and growth state transition in Schizosaccharomyces pombe.

  2001cited by this paper
• Trophic Factor Withdrawal: p38 Mitogen-Activated Protein Kinase Activates NHE1, Which Induces Intracellular Alkalinization

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• Osmotic Stimulation of the Na+/H+ Exchanger NHE1: Relationship to the Activation of Three MAPK Pathways

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• Polarization of Na+/H+ and Cl−/Hco 3 − Exchangers in Migrating Renal Epithelial Cells

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• Insulin stimulates NHE1 activity by sequential activation of phosphatidylinositol 3-kinase and protein kinase C zeta in human erythrocytes.

  2000cited by this paper
• Phosphoinositide 3-Kinase Is Involved in the Tumor-specific Activation of Human Breast Cancer Cell Na+/H+Exchange, Motility, and Invasion Induced by Serum Deprivation*

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• Malignant gliomas display altered pH regulation by NHE1 compared with nontransformed astrocytes.

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• Intracellular Ph Regulation by Na+/H+ Exchange Requires Phosphatidylinositol 4,5-Bisphosphate

  2000cited by this paper
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  1999cited by this paper
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  1998cited by this paper
• p160ROCK mediates RhoA activation of Na–H exchange

  1998cited by this paper
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  1998cited by this paper
• Polarized distribution of Na+/H+ exchanger isoforms in rabbit collecting duct cells.

  1998cited by this paper
• Squalamine inhibits angiogenesis and solid tumor growth in vivo and perturbs embryonic vasculature.

  1998cited by this paper
• Calmodulin-binding autoinhibitory domain controls "pH-sensing" in the Na+/H+ exchanger NHE1 through sequence-specific interaction.

  1997cited by this paper
• The p42/p44 Mitogen-activated Protein Kinase Cascade Is Determinant in Mediating Activation of the Na+/H+ Exchanger (NHE1 Isoform) in Response to Growth Factors*

  1997cited by this paper
• Squalamine, a novel am1nosterol antibiotic, is a spec II-U inhibitor of epithelial brush border Na /H exchanger isoform NHE3.

  1996cited by this paper
• Cell migration: a physically integrated molecular process.

  1996cited by this paper
• Acidic pH enhances the invasive behavior of human melanoma cells

  1996cited by this paper
• Growth factor activation and "H(+)-sensing" of the Na+/H+ exchanger isoform 1 (NHE1). Evidence for an additional mechanism not requiring direct phosphorylation.

  1994cited by this paper
• The Na+/H+ exchanger isoform 1 (NHE1) is a novel member of the calmodulin-binding proteins. Identification and characterization of calmodulin-binding sites.

  1994cited by this paper
• Migration-associated volume changes in neutrophils facilitate the migratory process in vitro.

  1994cited by this paper
• Functional characterization of three isoforms of the Na+/H+ exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role in cell proliferation.

  1994cited by this paper
• The Na+/H+ antiporter cytoplasmic domain mediates growth factor signals and controls "H(+)-sensing".

  1992cited by this paper
• Regulation of intracellular pH in tumor cell lines: influence of microenvironmental conditions.

  1992cited by this paper
• Structure of the 5'-flanking regulatory region and gene for the human growth factor-activatable Na/H exchanger NHE-1.

  1991cited by this paper
• Alpha 2-adrenergic receptors and the Na+/H+ exchanger in the intestinal epithelial cell line, HT-29.

  1989cited by this paper
• Induction of v-mos and activated Ha-ras oncogene expression in quiescent NIH 3T3 cells causes intracellular alkalinisation and cell-cycle progression.

  1987cited by this paper
• Microinjection of ras p21 induces a rapid rise in intracellular pH

  1987cited by this paper
• Regulation of human neutrophil chemotaxis by intracellular pH.

  1986cited by this paper
• Inhibition of human placental Na+-H+ exchanger by cimetidine.

  1986cited by this paper
• Effect of insulin on intracellular pH in frog skeletal muscle fibers.

  1985cited by this paper
• Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH

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• Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts

  1983cited by this paper
• Serum, platelet-derived growth factor, vasopressin and phorbol esters increase intracellular pH in Swiss 3T3 cells.

  1983cited by this paper
• Platelet-derived growth factor stimulates Na+/H+ exchange and induces cytoplasmic alkalinization in NR6 cells.

  1983cited by this paper
• Bioenergetics and the problem of tumor growth.

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• Tumor angiogenesis: therapeutic implications.

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