Multifaceted roles for thymine DNA glycosylase in embryonic development and human carcinogenesis.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Acta Biochimica et Biophysica Sinica

• Publication date

  2015-09-14

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/abbs/gmv083PMID 26370152PMCID PMC4689155
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Robust quantitative assessments of cytosine modifications and changes in the expressions of related enzymes in gastric cancer

  2015cited by this paper
• DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations

  2015cited by this paper
• TET proteins and the control of cytosine demethylation in cancer

  2015cited by this paper
• Gadd45a promotes DNA demethylation through TDG

  2015cited by this paper
• A Germline Polymorphism of Thymine DNA Glycosylase Induces Genomic Instability and Cellular Transformation

  2014cited by this paper
• Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands

  2014cited by this paper
• Thymine DNA Glycosylase Is a Positive Regulator of Wnt Signaling in Colorectal Cancer*

  2014influential reference
• Active DNA demethylation is required for complete imprint erasure in primordial germ cells

  2014cited by this paper
• Tet and TDG mediate DNA demethylation essential for mesenchymal-to-epithelial transition in somatic cell reprogramming.

  2014cited by this paper
• A TDG/CBP/RARα Ternary Complex Mediates the Retinoic Acid-dependent Expression of DNA Methylation-sensitive Genes

  2014cited by this paper
• Thymine DNA glycosylase promotes transactivation of β-catenin/TCFs by cooperating with CBP.

  2014cited by this paper
• Cancer statistics, 2014

  2014cited by this paper
• DNA Demethylation Pathways: Recent Insights

  2013cited by this paper
• Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk.

  2013cited by this paper
• Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase.

  2013cited by this paper
• MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles.

  2013cited by this paper
• Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation

  2013cited by this paper
• Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population.

  2013cited by this paper
• TET enzymes, TDG and the dynamics of DNA demethylation

  2013cited by this paper
• DNA demethylation by TDG.

  2012cited by this paper
• Transcriptional regulation of thymine DNA glycosylase (TDG) by the tumor suppressor protein p53

  2012cited by this paper
• Unique mutational profile associated with a loss of TDG expression in the rectal cancer of a patient with a constitutional PMS2 deficiency

  2012cited by this paper
• A population-based study of DNA repair gene variants in relation to non-melanoma skin cancer as a marker of a cancer-prone phenotype.

  2012cited by this paper
• Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

  2011cited by this paper
• Thymine DNA Glycosylase Can Rapidly Excise 5-Formylcytosine and 5-Carboxylcytosine

  2011cited by this paper
• In brief

  2011influential reference
• Active DNA demethylation by oxidation and repair

  2011cited by this paper
• Functional Mechanisms for Human Tumor Suppressors

  2010cited by this paper
• Active DNA demethylation: many roads lead to Rome

  2010cited by this paper
• The interaction between thymine DNA glycosylase and nuclear receptor coactivator 3 is required for the transcriptional activation of nuclear hormone receptors

  2009cited by this paper
• Opposing regulatory roles of phosphorylation and acetylation in DNA mispair processing by thymine DNA glycosylase

  2009cited by this paper
• Base Excision by Thymine DNA Glycosylase Mediates DNA-Directed Cytotoxicity of 5-Fluorouracil

  2009cited by this paper
• Thymine-DNA glycosylase interacts with and functions as a coactivator of p53 family proteins.

  2008cited by this paper
• Cyclical DNA methylation of a transcriptionally active promoter

  2008cited by this paper
• Nuclear receptors: Decoding metabolic disease

  2008cited by this paper
• The thymine-DNA glycosylase regulatory domain: residual structure and DNA binding.

  2008cited by this paper
• The enigmatic thymine DNA glycosylase.

  2007cited by this paper
• Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability.

  2006cited by this paper
• Genomic DNA methylation: the mark and its mediators.

  2006cited by this paper
• DNA Hypermethylation and Partial Gene Silencing of Human Thymine-DNA Glycosylase in Multiple Myeloma Cell Lines

  2006cited by this paper
• Crystal structure of SUMO-3-modified thymine-DNA glycosylase.

  2006cited by this paper
• Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair

  2006influential reference
• SUMO-1-Dependent Allosteric Regulation of Thymine DNA Glycosylase Alters Subnuclear Localization and CBP/p300 Recruitment

  2006influential reference
• Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition

  2006influential reference
• DNA methylation and human disease

  2005cited by this paper
• Functionality of human thymine DNA glycosylase requires SUMO-regulated changes in protein conformation.

  2005cited by this paper
• T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif

  2005cited by this paper
• Repair and genetic consequences of endogenous DNA base damage in mammalian cells.

  2004cited by this paper
• Polymorphisms in TDG and MGMT Genes – Epidemiological and Functional Study in Lung Cancer Patients from Poland

  2004cited by this paper
• Glycosylation regulates Notch signalling

  2003cited by this paper
• Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair.

  2003cited by this paper
• T:G Mismatch-specific Thymine-DNA Glycosylase Potentiates Transcription of Estrogen-regulated Genes through Direct Interaction with Estrogen Receptor α*

  2003cited by this paper
• Beyond Watson and Crick: DNA Methylation and Molecular Enzymology of DNA Methyltransferases

  2002cited by this paper
• Modification of the human thymine‐DNA glycosylase by ubiquitin‐like proteins facilitates enzymatic turnover

  2002cited by this paper
• Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription.

  2002cited by this paper
• The DNA Glycosylase T:G Mismatch-specific Thymine DNA Glycosylase Represses Thyroid Transcription Factor-1-activated Transcription*

  2001cited by this paper
• DNA mismatch repair and cancer.

  2001cited by this paper
• The alpha/beta fold uracil DNA glycosylases: a common origin with diverse fates

  2000cited by this paper
• Separating Substrate Recognition from Base Hydrolysis in Human Thymine DNA Glycosylase by Mutational Analysis*

  2000cited by this paper
• Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum.

  1999cited by this paper
• Genomic analysis of the thymine-DNA glycosylase (TDG) gene on 12q22–q24.1 in human pancreatic ductal adenocarcinoma

  1999cited by this paper
• Human Thymine DNA Glycosylase Binds to Apurinic Sites in DNA but Is Displaced by Human Apurinic Endonuclease 1*

  1999cited by this paper
• 3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase.

  1998cited by this paper
• Retinoic Acid Receptors Interact Physically and Functionally with the T:G Mismatch-specific Thymine-DNA Glycosylase*

  1998cited by this paper
• Expression of T : G mismatch-specific thymidine-DNA glycosylase and DNA methyl transferase genes during development and tumorigenesis

  1998influential reference
• A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch.

  1998cited by this paper
• Human thymine-DNA glycosylase maps at chromosome 12q22-q24.1: a region of high loss of heterozygosity in gastric cancer.

  1997influential reference
• Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells.

  1994cited by this paper
• The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells.

  1993cited by this paper
• Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun.

  1992cited by this paper
• Spontaneous deamination of cytosine and 5-methylcytosine residues in DNA and replacement of 5-methylcytosine residues with cytosine residues.

  1990cited by this paper
• In vitro correction of G o T mispairs to G o C pairs in nuclear extracts from human cells

  1989cited by this paper
• Cancer statistics

  1989cited by this paper
• The CpG dinucleotide and human genetic disease

  1988cited by this paper
• Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells.

  1982cited by this paper
• Heat- and alkali-induced deamination of 5-methylcytosine and cytosine residues in DNA.

  1982cited by this paper
• Carcinogens are mutagens: their detection and classification.

  1973cited by this paper

• α-ketoglutarate/succinate ratio imbalance impairs thymine DNA glycosylase function and base excision repair process increasing susceptibility to pancreatic cancer.

  2026cites this paper
• MiR-27a-3p binds to TET1 mediated DNA demethylation of ADCY6 regulates breast cancer progression via epithelial-mesenchymal transition

  2022cites this paper
• Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine

  2022cites this paper
• Targeting the Proline–Glutamine–Asparagine–Arginine Metabolic Axis in Amino Acid Starvation Cancer Therapy

  2021cites this paper
• Andrographolide Against Lung Cancer-New Pharmacological Insights Based on High-Throughput Metabolomics Analysis Combined with Network Pharmacology

  2021cites this paper
• Transcription profiles of oocytes during maturation and embryos during preimplantation development in vivo in the goat.

  2020cites this paper
• RETRACTED ARTICLE: The HOTAIRM1/miR-107/TDG axis regulates papillary thyroid cancer cell proliferation and invasion

  2020cites this paper
• Insulin and Metformin Control Cell Proliferation by Regulating TDG-Mediated DNA Demethylation in Liver and Breast Cancer Cells

  2020cites this paper
• Pathogenic 12-kb copy-neutral inversion in syndromic intellectual disability identified by high-fidelity long-read sequencing.

  2020cites this paper
• p53 and TDG are dominant in regulating the activity of the human de novo DNA methyltransferase DNMT3A on nucleosomes

  2020cites this paper
• Additional functions of selected proteins involved in DNA repair.

  2019cites this paper
• DNA Methylation Changes in Cancer

  2017cites this paper
• The application of genome-wide 5-hydroxymethylcytosine studies in cancer research.

  2017cites this paper
• Active DNA demethylation by DNA repair: Facts and uncertainties.

  2016cites this paper
• Thymine DNA Glycosylase Gene Knockdown Can Affect the Differentiation of Pig Preadipocytes

  2016cites this paper
• The role of thymine DNA glycosylase (TDG) and DNA demethylation in TGF beta signaling

  2015cites this paper
• New hopes in the fight against cancer: a special issue on targeted anti-cancer drug discovery and cell signaling.

  2015cites this paper