Development of Artificial Substitutes for Upper Digestive Tract: Personal Experience of Trials and Errors

구강, 인두, 식도 등을 포함하는 일련의 소화기관을 상부소 화기라고 한다. 소장과 대장 등의 하부소화기는 잘 알려진 바 와 같이 장기 전체의 길이가 매우 길어, 악성 종양 등의 치료 를 위해 장기의 일부를 제거하더라도 남아 있는 정상조직을 이용하여 재건하는 것이 표준 치료이고 동일한 자신의 장기 부위를 사용하므로 기능적으로도 최선의 결과를 얻는 것이 가능하다. 이에 반하여 상부소화기는 장기의 길이가 하부소 화기처럼 길지 않고 따라서 장기의 일부를 제거하는 경우 남 은 장기를 이용하여 재건하는 데 한계가 생긴다. 따라서, 구 강 및 인두의 재건은 신체 다른 부위의 조직을 이용하는 유리 피판(free flap)이나 유경 피판(pedicled flap) 등을 이용하게 되고 식도는 위(stomach)를 식도의 형태로 만들어 남아 있는 식도조직과 연결하는 방법을 주로 사용하게 된다. 또 하나의 매우 특징적인 점은, 사람과 같은 고등동물에서 는 호흡과 삼킴 작용이 분리되어 있고 호흡과 삼킴을 동시에 하는 것이 아니라 호흡하는 동안에는 호흡과 관련된 후두가 열리고 뒤쪽의 식도 입구 부위는 닫히며, 삼킴 과정이 시작되 면 반대로 후두는 닫히고 식도 입구 부위는 열리면서 호흡 튜 브는 막히고 삼킴 튜브만이 열리면서 음식의 안전한 이동이 가능해진다는 점이다. 식도 내로 이동한 음식은 식도의 연동 운동을 통하여 위로 이동하게 되는데 식도는 평상시에는 내 강이 거의 닫혀 있고 음식이 유입되어 팽창하고 연동운동으 로 진행하면서 순차적 팽창과 수축을 진행하게 된다는 또 하 나의 특유의 성질을 가지고 있다. 이러한 연동운동의 중요 성은 사람과 같은 직립개체가 아닌 동물 실험에서 더욱 분명 Development of Artificial Substitutes for Upper Digestive Tract: Personal Experience of Trials and Errors

• Publication year

  2019

• Venue

  Korean Journal of Otorhinolaryngology-head and Neck Surgery

• Publication date

  2019-12-21

• Fields of study

  Medicine, Linguistics

• Identifiers
  DOI 10.3342/kjorl-hns.2019.00710
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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