Enhanced neuronal loss under perinatal hypothyroidism involves impaired neurotrophic signaling and increased proteolysis of p75(NTR).

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Molecular and cellular neurosciences

• Publication date

  2009-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.mcn.2008.12.001PMID 19138744
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Current perspectives on the role of thyroid hormone in growth and development of cerebellum

  2008cited by this paper
• Palmitoylation of the C-terminal fragment of p75(NTR) regulates death signaling and is required for subsequent cleavage by gamma-secretase.

  2008cited by this paper
• Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons.

  2007cited by this paper
• Alteration of cerebellar neurotrophin mRNAs and the lack of TR augmentation by staggerer type RORα mutation

  2007cited by this paper
• The Failure in NGF Maturation and its Increased Degradation as the Probable Cause for the Vulnerability of Cholinergic Neurons in Alzheimer’s Disease

  2007cited by this paper
• Differentiation of ES cells into cerebellar neurons

  2007cited by this paper
• Alteration of cerebellar neurotropin messenger ribonucleic acids and the lack of thyroid hormone receptor augmentation by staggerer-type retinoic acid receptor-related orphan receptor-alpha mutation.

  2007cited by this paper
• The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm

  2007cited by this paper
• Thyroid hormone and cerebellar development

  2007cited by this paper
• Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain.

  2007cited by this paper
• Adaptive roles of programmed cell death during nervous system development.

  2006cited by this paper
• Increased pro-nerve growth factor and p75 neurotrophin receptor levels in developing hypothyroid rat cerebral cortex are associated with enhanced apoptosis.

  2006influential reference
• Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons.

  2006cited by this paper
• Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade.

  2006cited by this paper
• CHOP is involved in neuronal apoptosis induced by neurotrophic factor deprivation

  2006cited by this paper
• Receptors that mediate cellular dependence

  2005cited by this paper
• The p75 Neurotrophin Receptor Can Induce Autophagy and Death of Cerebellar Purkinje Neurons

  2004cited by this paper
• Regional expression of p75NTR contributes to neurotrophin regulation of cerebellar patterning.

  2003cited by this paper
• Trk receptors: roles in neuronal signal transduction.

  2003cited by this paper
• Hypothyroidism alters mitochondrial morphology and induces release of apoptogenic proteins during rat cerebellar development.

  2003cited by this paper
• Proteolytic Processing of the p75 Neurotrophin Receptor and Two Homologs Generates C-Terminal Fragments with Signaling Capability

  2003cited by this paper
• Hypothyroidism alters the expression of Bcl-2 family genes to induce enhanced apoptosis in the developing cerebellum.

  2003cited by this paper
• Apoptosis in human embryo development: 3. Fas‐induced apoptosis in brian primary cultures

  2001cited by this paper
• The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease.

  2001cited by this paper
• Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.

  2001cited by this paper
• Chopper, a New Death Domain of the p75 Neurotrophin Receptor That Mediates Rapid Neuronal Cell Death*

  2000cited by this paper
• Promoter-specific regulation of the brain-derived neurotropic factor gene by thyroid hormone in the developing rat cerebellum.

  1999cited by this paper
• Programmed Cell Death of Embryonic Motoneurons Triggered through the FAS Death Receptor

  1999cited by this paper
• p75-Mediated NF-κB Activation Enhances the Survival Response of Developing Sensory Neurons to Nerve Growth Factor

  1999cited by this paper
• Promoter-Specific Regulation of the Brain-Derived Neurotropic Factor Gene by Thyroid Hormone in the Developing Rat Cerebellum1.

  1999cited by this paper
• RORα Gene Expression in the Perinatal Rat Cerebellum: Ontogeny and Thyroid Hormone Regulation.

  1998cited by this paper
• Apoptosis in the developing cerebellum of the thyroid hormone deficient rat.

  1998cited by this paper
• ROR alpha gene expression in the perinatal rat cerebellum: ontogeny and thyroid hormone regulation.

  1998cited by this paper
• Neurotrophins: the biological paradox of survival factors eliciting apoptosis

  1998cited by this paper
• Neurotrophins Protect Cultured Cerebellar Granule Neurons against the Early Phase of Cell Death by a TwoComponent Mechanism

  1997cited by this paper
• Autocrine regulation of apoptosis and bcl-2 expression by nerve growth factor in early differentiating cerebellar granule neurons involves low affinity neurotrophin receptor.

  1997cited by this paper
• Transgenic Mice Expressing the Intracellular Domain of the p75 Neurotrophin Receptor Undergo Neuronal Apoptosis

  1997cited by this paper
• Kainic acid increases the expression of the prohormone convertases furin and PC1 in the mouse hippocampus.

  1996cited by this paper
• Neurotrophins promote the survival and development of neurons in the cerebellum of hypothyroid rats in vivo

  1996influential reference
• Thyroid hormone promotes BCL‐2 expression and prevents apoptosis of early differentiating cerebellar granule neurons

  1995cited by this paper
• Expression of neurotrophins and the trk family of neurotrophin receptors in normal and hypothyroid rat brain.

  1994influential reference
• Induction of apoptosis by the low-affinity NGF receptor.

  1993cited by this paper
• Effects of perinatal hypo- and hyperthyroidism on the levels of nerve growth factor and its low-affinity receptor in cerebellum.

  1993influential reference
• Involvement of a metalloprotease in low-affinity nerve growth factor receptor truncation: inhibition of truncation in vitro and in vivo

  1993cited by this paper
• Increased levels of truncated nerve growth factor receptor in urine of mildly demented patients with Alzheimer's disease.

  1993cited by this paper
• Biochemical, immunocytochemical and morphological evidence for an interaction between thyroid hormone and nerve growth factor in the developing cerebellum of normal and hypothyroid rats.

  1991cited by this paper
• Effects of thyroid dysfunction on the development of the rat cerebellum, with special reference to cell death within the internal granular layer.

  1977cited by this paper

• Spatio-temporal effects of iodine/thyroid hormone deficiency on neurodevelopment and plausible amelioration approaches beyond the critical window

  2025cites this paper
• Relationship between thyroid-stimulating hormone, BDNF levels, and hippocampal volume in antipsychotic-naïve first-episode psychosis patients

  2023cites this paper
• Maternal exposure to the environmental pollutant "BDE-47" impairs the postnatal development of rat cerebellar cortex by modulating neuronal proliferation, synaptogenesis, NGF and BDNF pathways.

  2022cites this paper
• The effects of curcumin in learning and memory impairment associated with hypothyroidism in juvenile rats: the role of nitric oxide, oxidative stress, and brain-derived neurotrophic factor

  2022cites this paper
• Brain‑derived neurotrophic factor and nitric oxide contribute to protective effects of rosiglitazone on learning and memory in hypothyroid rats.

  2021cites this paper
• Maternal Subclinical Hypothyroidism in Rats Impairs Spatial Learning and Memory in Offspring by Disrupting Balance of the TrkA/p75NTR Signal Pathway

  2021cites this paper
• Evaluation of Nestin and Reelin Genes Expression in the Brain of Hypothyroid Neonatal Rats Treated with Emamectin Benzoate During Lactation Period

  2021cites this paper
• Adverse Outcome Pathway on inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment

  2019cites this paper
• The Role of Astrocytes in the Development of the Cerebellum

  2019cites this paper
• Thyroid Hormone Enhances Neurite Outgrowth in Neuroscreen 1 Cells

  2018cites this paper
• The effect of iodine-containing thyroid hormones on the tissues of the maxillofacial area

  2018cites this paper
• Subclinical hypothyroidism in pregnant rats impaired learning and memory of their offspring by promoting the p75NTR signal pathway

  2018cites this paper
• Perinatal Hypothyroidism and Cytoskeleton Dysfunction

  2017cites this paper
• Neuroprotective effects of Nigella sativa extract upon the hippocampus in PTU-induced hypothyroidism juvenile rats: A stereological study

  2017influential citation
• Vitamin C prevents hypothyroidism associated neuronal damage in the hippocampus of neonatal and juvenile rats: A stereological study.

  2017cites this paper
• IGF1 neuronal response in the absence of MECP2 is dependent on TRalpha 3

  2016cites this paper
• Thyroid Hormones Crosstalk with Growth Factors: Old Facts and New Hypotheses

  2015cites this paper
• Histone deacetylase inhibition reduces hypothyroidism-induced neurodevelopmental defects in rats.

  2015cites this paper
• The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats.

  2015cites this paper
• Subcortical Band Heterotopia in Rat Offspring Following Maternal Hypothyroxinaemia: Structural and Functional Characteristics

  2014cites this paper
• Thyroxin Treatment Protects Against White Matter Injury in The Immature Brain via Brain-Derived Neurotrophic Factor

  2013cites this paper
• Interplay between thyroxin, BDNF and GABA in injured neurons.

  2013influential citation
• Brain derived neurotrophic factor and oxidative stress index in pups with developmental hypothyroidism: neuroprotective effects of selenium.

  2013cites this paper
• Experimental hypothyroidism during pregnancy affects nociception and locomotor performance of offspring in rats

  2013cites this paper
• Iodine plus n-3 fatty acid supplementation augments rescue of postnatal neuronal abnormalities in iodine-deficient rat cerebellum

  2013cites this paper
• Developmental thyroid hormone insufficiency and brain development: a role for brain-derived neurotrophic factor (BDNF)?

  2013influential citation
• A bimodal influence of thyroid hormone on cerebellum oligodendrocyte differentiation.

  2012cites this paper
• Perinatal iodine deficiency and hypothyroidism increase cell apoptosis and alter doublecortin and reelin protein expressions in rat cerebellum.

  2012cites this paper
• Influência do hipotireoidismo gestacional experimental na nocicepção e desempenho motor da prole de ratos

  2012cites this paper
• Developmental Iodine Deficiency and Hypothyroidism Impair Neural Development, Upregulate Caveolin-1, and Downregulate Synaptotagmin-1 in the Rat Cerebellum

  2011cites this paper
• Developmental thyroid hormone insufficiency reduces expression of brain-derived neurotrophic factor (BDNF) in adults but not in neonates.

  2011cites this paper
• Thyroid disorders in pregnancy.

  2011cites this paper
• Effect of hypothyroxinemia on thyroid hormone responsiveness and action during rat postnatal neocortical development.

  2011cites this paper
• Effects of hypothyroidism on programmed cell death in forebrain structures of the rat during development and in the adult

  2010cites this paper
• Evidence of a bigenomic regulation of mitochondrial gene expression by thyroid hormone during rat brain development.

  2010cites this paper
• Effects of perinatal hypothyroidism on regulation of reelin and brain-derived neurotrophic factor gene expression in rat hippocampus: Role of DNA methylation and histone acetylation.

  2010cites this paper
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• Original Contribution

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