Solution properties of an antidiabetic drug metformin hydrochloride in aqueous urea and thiourea solutions: A physicochemical study

Abstract Densities, speeds of sound and viscosities of metformin hydrochloride in water and in (0.025, 0.050 and 0.075) mol. kg−1 aqueous urea and thiourea solutions have been measured at T = (293.15, 298.15, 303.15, 308.15 and 313.15) K. From density data, apparent molar volume, Vϕ, limiting apparent molar volume, V0ϕ, slope, Sv, partial molar volume of transfer, ∆trV0ϕ, limiting apparent molar expansivity, E0ϕ, and Hepler's constant, (∂2V0ϕ/∂T2)P, have been measured. The apparent molar isentropic compression, Kϕ,s, limiting apparent molar isentropic compression, K0ϕ,s, slope, Sk, limiting apparent molar isentropic compression of transfer, ∆trK0ϕ,s and hydration number, nH have been calculated from speed of sound data. The viscosity data has been analyzed using Jones–Dole equation for viscosity B-coefficients and viscosity B-coefficients of transfer ΔtrB. The results have been interpreted in terms of solute-solvent and solute-solute interactions and structure making/breaking ability of solute in the aqueous solution of urea/thiourea.

• Publication year

  2020

• Venue

  Journal of Molecular Liquids

• Publication date

  2020-02-15

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.molliq.2019.111985
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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