1α,25-Dihydroxyvitamin D3 Up-Regulates P-Glycoprotein via the Vitamin D Receptor and Not Farnesoid X Receptor in Both fxr(−/−) and fxr(+/+) Mice and Increased Renal and Brain Efflux of Digoxin in Mice In Vivo

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  2011-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1124/jpet.111.179101PMID 21421739
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Comparative effects of doxercalciferol (1α-hydroxyvitamin D₂) versus calcitriol (1α,25-dihydroxyvitamin D₃) on the expression of transporters and enzymes in the rat in vivo.

  2011cited by this paper
• Effects of 1alpha,25-dihydroxyvitamin D3 on transporters and enzymes of the rat intestine and kidney in vivo.

  2009cited by this paper
• Up-Regulation of Transporters and Enzymes by the Vitamin D Receptor Ligands, 1α,25-Dihydroxyvitamin D3 and Vitamin D Analogs, in the Caco-2 Cell Monolayer

  2009cited by this paper
• Involvement of Vitamin D Receptor in the Intestinal Induction of Human ABCB1

  2009influential reference
• Up‐regulation of P‐glycoprotein by HIV protease inhibitors in a human brain microvessel endothelial cell line

  2009cited by this paper
• 1α,25‐dihydroxyvitamin D3 triggered vitamin D receptor and farnesoid X receptor‐like effects in rat intestine and liver in vivo

  2009cited by this paper
• The Antiepileptic Drug Topiramate is a Substrate for Human P-glycoprotein but Not Multidrug Resistance Proteins

  2009cited by this paper
• Identification of the functional vitamin D response elements in the human MDR1 gene.

  2008cited by this paper
• Oseltamivir (Tamiflu) Efflux Transport at the Blood-Brain Barrier via P-Glycoprotein

  2008cited by this paper
• Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells

  2008influential reference
• Population pharmacokinetic modelling of non‐linear brain distribution of morphine: influence of active saturable influx and P‐glycoprotein mediated efflux

  2007cited by this paper
• The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-α and -β genes

  2006influential reference
• In Vivo Activation of Human Pregnane X Receptor Tightens the Blood-Brain Barrier to Methadone through P-Glycoprotein Up-Regulation

  2006cited by this paper
• P-Glycoprotein and an Unstirred Water Layer Barring Digoxin Absorption in the Vascularly Perfused Rat Small Intestine Preparation: Induction Studies with Pregnenolone-16α-carbonitrile

  2006cited by this paper
• Promise of vitamin D analogues in the treatment of hyperproliferative conditions

  2006cited by this paper
• Evolution and function of the NR1I nuclear hormone receptor subfamily (VDR, PXR, and CAR) with respect to metabolism of xenobiotics and endogenous compounds.

  2006cited by this paper
• Transactivation of Rat Apical Sodium-Dependent Bile Acid Transporter and Increased Bile Acid Transport by 1α,25-Dihydroxyvitamin D3 via the Vitamin D Receptor

  2006cited by this paper
• Effects of culture conditions on CYP3A4 and MDR1 mRNA induction by 1a,25- dihydroxyvitamin D3 in human intestinal cell lines, Caco-2 and LS180.

  2005influential reference
• The effects of culture conditions on CYP3A4 and MDR1 mRNA induction by 1alpha,25-dihydroxyvitamin D(3) in human intestinal cell lines, Caco-2 and LS180.

  2005cited by this paper
• The normal liver harbors the vitamin D nuclear receptor in nonparenchymal and biliary epithelial cells

  2003cited by this paper
• Liver Receptor Homologue-1 Mediates Species- and Cell Line-specific Bile Acid-dependent Negative Feedback Regulation of the Apical Sodium-dependent Bile Acid Transporter*

  2003cited by this paper
• Transport of HIV-Protease Inhibitors Across 1α,25di-Hydroxy Vitamin D3-Treated Calu-3 Cell Monolayers: Modulation of P-Glycoprotein Activity

  2002cited by this paper
• Drugs as P-glycoprotein substrates, inhibitors, and inducers

  2002cited by this paper
• Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human intestinal epithelia.

  2001cited by this paper
• A new physiologically based, segregated-flow model to explain route-dependent intestinal metabolism.

  2000cited by this paper
• Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

  2000cited by this paper
• The Contribution of P‐glycoprotein to Pharmacokinetic Drug‐Drug Interactions

  1999cited by this paper
• Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice.

  1999influential reference
• Carrier‐mediated entry of 4‐methylumbelliferyl sulfate: Characterization by the multiple‐indicator dilution technique in perfused rat liver

  1998cited by this paper
• Physiological Parameters in Laboratory Animals and Humans

  1993influential reference
• Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. II. Distribution of phencyclidine in the rat.

  1991cited by this paper
• The effect of age on digoxin pharmacokinetics in Fischer-344 rats.

  1990influential reference
• Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

  1990cited by this paper
• The effect of immunization with digoxin-specific antibodies on digoxin disposition in the mouse.

  1984influential reference
• Effect of plasma protein binding on renal clearance of drugs.

  1980cited by this paper
• Physiologically based pharmacokinetic model for digoxin disposition in dogs and its preliminary application to humans.

  1977influential reference
• Physiologically based pharmacokinetic model for digoxin distribution and elimination in the rat.

  1977influential reference
• A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants.

  1976cited by this paper
• Renal Tubular Secretion of Digoxin

  1974influential reference
• Biological activity of 1,25-dihydroxyvitamin D3 in the rat.

  1973cited by this paper
• Protein measurement with the Folin phenol reagent.

  1951cited by this paper

• Transporters and drug secretion into human breast milk

  2025cites this paper
• Multimodal Imaging of Blood–Brain Barrier Dysfunction in Parkinson's Disease: From Pathological Mechanisms to Therapeutic Opportunities

  2025cites this paper
• Vitamin D Deficiency Does Not Affect Cognition and Neurogenesis in Adult C57Bl/6 Mice

  2024cites this paper
• Blood–brain barrier alterations and their impact on Parkinson’s disease pathogenesis and therapy

  2024cites this paper
• Correlation between hyperlipidemia and serum vitamin D levels in an adult Chinese cohort

  2024cites this paper
• Zinc finger proteins and ATP‐binding cassette transporter‐dependent multidrug resistance

  2023cites this paper
• Study Models of Drug–Drug Interactions Involving P-Glycoprotein: The Potential Benefit of P-Glycoprotein Modulation at the Kidney and Intestinal Levels

  2023cites this paper
• Full spectrum of vitamin D immunomodulation in multiple sclerosis: mechanisms and therapeutic implications

  2022cites this paper
• Vitamin D3 supplementation may attenuate morphological and molecular abnormalities of the olfactory bulb in a mouse model of Down syndrome.

  2022cites this paper
• Significance of the Vitamin D Receptor on Crosstalk with Nuclear Receptors and Regulation of Enzymes and Transporters

  2022cites this paper
• The Interplay between Vitamin D, Exposure of Anticholinergic Antipsychotics and Cognition in Schizophrenia

  2022cites this paper
• The negative impact of vitamin D on antipsychotic drug exposure may counteract its potential benefits in schizophrenia

  2022cites this paper
• Regulation of P-Glycoprotein in the Brain

  2022cites this paper
• Effects of 1α,25-Dihydroxyvitamin D3 on the Pharmacokinetics of Procainamide and Its Metabolite N-Acetylprocainamide, Organic Cation Transporter Substrates, in Rats with PBPK Modeling Approach

  2021cites this paper
• Impact of age, hypercholesterolemia, and the vitamin D receptor on brain endogenous β‐amyloid peptide accumulation in mice

  2021cites this paper
• Effects of vitamin D on drugs: Response and disposal.

  2020cites this paper
• Human Amyloid- b 40 Kinetics after Intravenous and Intracerebroventricular Injections and Calcitriol Treatment in Rats In Vivo s

  2020cites this paper
• Efflux transporters in cancer resistance: Molecular and functional characterization of P-glycoprotein

  2020cites this paper
• Novel insights into the organic solute transporter alpha/beta, OSTα/β: From the bench to the bedside.

  2020cites this paper
• Human Amyloid-β40 Kinetics after Intravenous and Intracerebroventricular Injections and Calcitriol Treatment in Rats In Vivo

  2020influential citation
• Putative role of vitamin D in the mechanism of alcoholism and other addictions - a hypothesis.

  2020cites this paper
• Differential Effects of 1α,25-Dihydroxyvitamin D3 on the Expressions and Functions of Hepatic CYP and UGT Enzymes and Its Pharmacokinetic Consequences In Vivo

  2020cites this paper
• The Segregated Intestinal Flow Model (SFM) for Drug Absorption and Drug Metabolism: Implications on Intestinal and Liver Metabolism and Drug–Drug Interactions

  2020cites this paper
• Bile Acids as Signaling Molecules

  2020cites this paper
• Administration of Vitamin D Metabolites Affects RNA Expression of Xenobiotic Metabolising Enzymes and Function of ABC Transporters in Rats

  2019cites this paper
• Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha

  2019cites this paper
• Vitamin D3 increases the Caspase-3 p12, MTHFR, and P-glycoprotein reducing amyloid-β42 in the kidney of a mouse model for Down syndrome.

  2019cites this paper
• Sustained delivery of a camptothecin prodrug – CZ48 by nanosuspensions with improved pharmacokinetics and enhanced anticancer activity

  2019cites this paper
• Therapeutic targets of vitamin D receptor ligands and their pharmacokinetic effects by modulation of transporters and metabolic enzymes

  2019cites this paper
• ABC transporters in neurological disorders: an important gateway for botanical compounds mediated neuro-therapeutics.

  2019cites this paper
• Modulation of ABC Transporters by Nuclear Receptors: Physiological, Pathological and Pharmacological Aspects.

  2019cites this paper
• Alterations in gene expression in vitamin D‐deficiency: Down‐regulation of liver Cyp7a1 and renal Oat3 in mice

  2018cites this paper
• Highlighting Vitamin D Receptor–Targeted Activities of 1α,25-Dihydroxyvitamin D3 in Mice via Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling

  2018influential citation
• Use of Subcutaneous and Intraperitoneal Administration Methods to Facilitate Cassette Dosing in Microdialysis Studies in Rats

  2018cites this paper
• Potencies of vitamin D analogs, 1α‐hydroxyvitamin D3, 1α‐hydroxyvitamin D2 and 25‐hydroxyvitamin D3, in lowering cholesterol in hypercholesterolemic mice in vivo

  2018cites this paper
• Differential regulation of intestinal and hepatic CYP3A by 1α,25‐dihydroxyvitamin D3: Effects on in vivo oral absorption and disposition of buspirone in rats

  2018influential citation
• Quantitative Intracerebral Microdialysis Studies to Determine Unbound Extracellular Fluid Drug Concentrations in Discrete Areas of the Brain

  2018cites this paper
• Modulation of the ATP-Binding Cassette B1 Transporter by Neuro-Inflammatory Cytokines: Role in the Pathogenesis of Alzheimer's Disease

  2018cites this paper
• ABC Transporters Involved in Cholestasis

  2017cites this paper
• Comparing early liver graft function from heart beating and living‐donors: A pilot study aiming to identify new biomarkers of liver injury

  2017cites this paper
• Pharmacokinetics and protein binding of MPT0B292

  2017cites this paper
• VDR-Targeted Activities of 1 , 25-Dihydroxyvitamin D 3 in Mice Via Physiologically-Based Pharmacokinetic-Pharmacodynamic Modeling

  2017influential citation
• P-glycoprotein (ABCB1) and Oxidative Stress: Focus on Alzheimer's Disease

  2017cites this paper
• Not only P-glycoprotein: Amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins.

  2017cites this paper
• Unequivocal evidence supporting the segregated flow intestinal model that discriminates intestine versus liver first-pass removal with PBPK modeling.

  2017cites this paper
• Vitamin D3 protects against A&bgr; peptide cytotoxicity in differentiated human neuroblastoma SH‐ SY5Y cells: A role for S1P1/p38MAPK/ATF4 axis

  2017cites this paper
• PBPK Modeling to Estimate Metabolite Formation From First-Pass Organs: Intestine and Liver

  2017cites this paper
• Influence of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on expression of P-glycoprotein and cytochrome P450 3A in sheep.

  2016cites this paper
• Physiologically-Based Pharmacokinetic-Pharmacodynamic Modeling of 1α,25-Dihydroxyvitamin D3 in Mice

  2016cites this paper
• Role and modulation of drug transporters in HIV-1 therapy.

  2016cites this paper
• Physiologically-Based Pharmacokinetic-Pharmacodynamic Modeling of 1 a , 25-Dihydroxyvitamin D 3 in Mice

  2016cites this paper
• Effects of 1α,25-Dihydroxyvitamin D3 on Intestinal Absorption and Disposition of Adefovir Dipivoxil and Its Metabolite, Adefovir, in Rats.

  2015cites this paper
• Effect of vitamin D on bioavailability and lipid lowering efficacy of simvastatin

  2015cites this paper
• Dealing with the complex drug-drug interactions: towards mechanistic models.

  2015cites this paper
• PKPD modelling to predict altered disposition of 1α,25‐dihydroxyvitamin D3 in mice due to dose‐dependent regulation of CYP27B1 on synthesis and CYP24A1 on degradation

  2015cites this paper
• The Effect of Vitamin D Supplementation on Plasma Aβ in an Older Population: A Randomized Control Trial

  2015cites this paper
• Modulation of P-glycoprotein efflux pump: induction and activation as a therapeutic strategy.

  2015cites this paper
• Elucidating the in vivo fate of nanocrystals using a physiologically based pharmacokinetic model: a case study with the anticancer agent SNX-2112

  2015cites this paper
• Vitamin D Receptor Activation Induces P-Glycoprotein and Increases Brain Efflux of Quinidine:An Intracerebral Microdialysis Study in Conscious Rats

  2014cites this paper
• Signaling pathways that regulate basal ABC transporter activity at the blood- brain barrier.

  2014cites this paper
• The Role of Canalicular ABC Transporters in Cholestasis

  2014cites this paper
• Special Section on Transporters in Toxicity and Disease — Minireview The Role of Canalicular ABC Transporters in Cholestasis

  2014cites this paper
• Effects of 1α,25-dihydroxyvitamin D3 , the natural vitamin D receptor ligand, on the pharmacokinetics of cefdinir and cefadroxil, organic anion transporter substrates, in rat.

  2014cites this paper
• Developments in renal pharmacogenomics and applications in chronic kidney disease

  2014cites this paper
• 1α,25-Dihydroxyvitamin D3 Reduces Cerebral Amyloid-β Accumulation and Improves Cognition in Mouse Models of Alzheimer's Disease

  2014cites this paper
• Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.

  2014cites this paper
• Role of the Vitamin D Receptor in MDR1/P-glycoprotein Regulation at the Blood-brain Barrier

  2014influential citation
• The Blood Brain Barrier (BBB)

  2014cites this paper
• ITC Recommendations for Transporter Kinetic Parameter Estimation and Translational Modeling of Transport‐Mediated PK and DDIs in Humans

  2013cites this paper
• 3D structures and ligand specificities of nuclear xenobiotic receptors CAR, PXR and VDR.

  2013cites this paper
• Comparative effects of 1α‐hydroxyvitamin D3 and 1,25‐dihydroxyvitamin D3 on transporters and enzymes in fxr(+/+) and fxr(‐/‐) mice

  2013cites this paper
• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

  2013cites this paper
• Role of nuclear receptors in the regulation of drug transporters in the brain.

  2013cites this paper
• Temporal changes in tissue 1α,25-dihydroxyvitamin D3, vitamin D receptor target genes, and calcium and PTH levels after 1,25(OH)2D3 treatment in mice.

  2013cites this paper
• ABC Transporters at the Blood–Brain Barrier

  2013cites this paper
• Commentary: Theoretical Predictions of Flow Effects on Intestinal and Systemic Availability in Physiologically Based Pharmacokinetic Intestine Models: The Traditional Model, Segregated Flow Model, and QGut Model

  2012cites this paper
• Why we need proper PBPK models to examine intestine and liver oral drug absorption.

  2012cites this paper
• Effects of 1α,25-dihydroxyvitamin D3 on transport and metabolism of adefovir dipivoxil and its metabolites in Caco-2 cells.

  2012cites this paper
• 1α,25‐Dihydroxyvitamin D3‐liganded vitamin D receptor increases expression and transport activity of P‐glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells

  2012cites this paper
• Top Three Pharmacogenomics and Personalized Medicine Applications at the Nexus of Renal Pathophysiology and Cardiovascular Medicine

  2011cites this paper
• Bile Acids and Their Receptors

  2010cites this paper
• BASIC AND TRANSLATIONAL — LIVER Vitamin D Receptor Activation Down-regulates the Small Heterodimer Partner and Increases CYP7A1 to Lower Cholesterol

  year unknowncites this paper