MBDin, a Novel MBD2-Interacting Protein, Relieves MBD2 Repression Potential and Reactivates Transcription from Methylated Promoters

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Molecular and Cellular Biology

• Publication date

  2003-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1128/MCB.23.5.1656-1665.2003PMID 12588985PMCID PMC151705
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• DNA methylation patterns and epigenetic memory.

  2002cited by this paper
• Promoter-specific Activation and Demethylation by MBD2/Demethylase*

  2002cited by this paper
• The fundamental role of epigenetic events in cancer

  2002cited by this paper
• Gene silencing quantitatively controls the function of a developmental trans-activator.

  2002cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• GTPase activity of dynamin and resulting conformation change are essential for endocytosis

  2001cited by this paper
• Methyl CpG‐binding proteins and transcriptional repression *

  2001cited by this paper
• A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

  2001cited by this paper
• Involvement of a Novel Zinc Finger Protein, MIZF, in Transcriptional Repression by Interacting with a Methyl-CpG-binding Protein, MBD2*

  2001cited by this paper
• Methyl-CpG-binding proteins. Targeting specific gene repression.

  2001cited by this paper
• Cancer epigenetics takes center stage.

  2001cited by this paper
• The Minimal Repression Domain of MBD2b Overlaps with the Methyl-CpG-binding Domain and Binds Directly to Sin3A*

  2000cited by this paper
• A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA.

  2000influential reference
• A Novel Member of the BTB/POZ Family, PATZ, Associates with the RNF4 RING Finger Protein and Acts as a Transcriptional Repressor*

  2000cited by this paper
• MBD2‐MBD3 complex binds to hemi‐methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase

  2000cited by this paper
• Trichostatin and Leptomycin: Inhibition of Histone Deacetylation and Signal‐Dependent Nuclear Export

  1999influential reference
• A mammalian protein with specific demethylase activity for mCpG DNA

  1999influential reference
• The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

  1999cited by this paper
• MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex

  1999cited by this paper
• MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1.

  1999cited by this paper
• Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.

  1999influential reference
• Cancer-epigenetics comes of age

  1999cited by this paper
• The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome.

  1999cited by this paper
• DNA methylation and chromatin modification.

  1999cited by this paper
• The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability

  1999cited by this paper
• Nuclear import and export pathways

  1999cited by this paper
• Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation

  1999cited by this paper
• CpG methylation, chromatin structure and gene silencing—a three‐way connection

  1998cited by this paper
• G protein mechanisms: insights from structural analysis.

  1997cited by this paper
• Cytosine methylation and the ecology of intragenomic parasites.

  1997cited by this paper
• DNA methylation: a molecular lock.

  1997cited by this paper
• X-chromosome inactivation in mammals.

  1997cited by this paper
• Genomic imprinting in mammals.

  1997cited by this paper
• Cell-specific transcriptional regulation and reactivation of galectin-1 gene expression are controlled by DNA methylation of the promoter region

  1996cited by this paper
• Characterization and functional dissection of the galactin‐1 gene promoter

  1995cited by this paper
• Identification of a signal for rapid export of proteins from the nucleus.

  1995cited by this paper
• Differential transcriptional regulation of c-myc promoter through the same DNA binding sites targeted by Sp1-like proteins.

  1995cited by this paper
• Transcriptional activators differ in their responses to overexpression of TATA-box-binding protein

  1995cited by this paper
• DNA methylation and genomic imprinting.

  1994cited by this paper
• Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1.

  1994cited by this paper
• A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands.

  1992cited by this paper
• Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.

  1992cited by this paper
• The essentials of DNA methylation.

  1992cited by this paper
• An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs.

  1987cited by this paper
• Regulation of the yeast HO gene.

  1985cited by this paper
• A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

  1983cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper
• Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins

  year unknowninfluential reference

• Dual genomic localizations and gene regulatory functions of MBD-2 with and without NuRD in Caenorhabditis elegans which lacks DNA methylation

  2026cites this paper
• SLC6A3 gene methylation may be associated with alcohol use disorder, but personality and life stress may not influence methylation

  2025cites this paper
• Methyl-CpG-binding domain 2 mitigates osteoarthritis through Steap3 promoter methylation and chondrocyte ferroptosis regulation

  2025cites this paper
• Nucleocytoplasmic shuttling of the GPN-loop GTPase Gpn3 is regulated by serum and cell density in MCF-12A mammary cells.

  2024cites this paper
• Comprehensive analysis of GPN1 in human cancer and its effects on the migration of hepatocellular carcinoma cells

  2024cites this paper
• Archaeal GPN-loop GTPases involve a lock-switch-rock mechanism for GTP hydrolysis

  2023cites this paper
• Targeting HNRNPM Inhibits Cancer Stemness and Enhances Antitumor Immunity in Wnt-activated Hepatocellular Carcinoma

  2022cites this paper
• Hypoxia-Induced Suppression of Alternative Splicing of MBD2 Promotes Breast Cancer Metastasis via Activation of FZD1

  2021cites this paper
• A nuclear proteome localization screen reveals the exquisite specificity of Gpn2 in RNA polymerase biogenesis

  2021cites this paper
• Analysis of DNA binding by human factor xeroderma pigmentosum complementation group A (XPA) provides insight into its interactions with nucleotide excision repair substrates

  2017cites this paper
• The Gpn3 Q279* cancer‐associated mutant inhibits Gpn1 nuclear export and is deficient in RNA polymerase II nuclear targeting

  2017cites this paper
• Human Gpn1 purified from bacteria binds guanine nucleotides and hydrolyzes GTP as a protein dimer stabilized by its C-terminal tail.

  2017cites this paper
• XPA: A key scaffold for human nucleotide excision repair.

  2016cites this paper
• Structure of GPN-Loop GTPase Npa3 and Implications for RNA Polymerase II Assembly

  2015cites this paper
• Structure of GPN-loop GTPase Npa3 and implications for RNA

  2015cites this paper
• Alteration of Scn3a expression is mediated via CpG methylation and MBD2 in mouse hippocampus during postnatal development and seizure condition.

  2015cites this paper
• Gpn1 and Gpn3 associate tightly and their protein levels are mutually dependent in mammalian cells

  2014cites this paper
• Role of PATZ1 as a potential tumor suppressor gene in thyroid cancer

  2013cites this paper
• TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters

  2013influential citation
• Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A.

  2013cites this paper
• Nuclear import of RNA polymerase II is coupled with nucleocytoplasmic shuttling of the RNA polymerase II-associated protein 2

  2013influential citation
• Eukaryotic GPN-loop GTPases paralogs use a dimeric assembly reminiscent of archeal GPN

  2013cites this paper
• A nuclear export sequence in GPN-loop GTPase 1, an essential protein for nuclear targeting of RNA polymerase II, is necessary and sufficient for nuclear export.

  2012cites this paper
• POZ-, AT-hook-, and Zinc Finger-containing Protein (PATZ) Interacts with Human Oncogene B Cell Lymphoma 6 (BCL6) and Is Required for Its Negative Autoregulation*

  2012cites this paper
• DNA Methylation and Histone Deacetylation: Interplay and Combined Therapy in Cancer

  2012influential citation
• Utilización de proteinas de fusión en el estudio de la localización subcelular de la GTPasa Parcs/Gpn3

  2012cites this paper
• A role for GPN-loop GTPase yGPN1 in sister chromatid cohesion

  2011cites this paper
• GTP-dependent Binding and Nuclear Transport of RNA Polymerase II by Npa3 Protein*

  2011cites this paper
• Preferential binding of the methyl-CpG binding domain protein 2 at methylated transcriptional start site regions

  2011cites this paper
• Human GTPases Associate with RNA Polymerase II To Mediate Its Nuclear Import

  2011cites this paper
• Increased BDNF promoter methylation in the Wernicke area of suicide subjects.

  2010cites this paper
• Role of CpG island methylation and MBD2 in immune cell gene regulation

  2010cites this paper
• Chromatin and DNA methylation dynamics during retinoic acid-induced RET gene transcriptional activation in neuroblastoma cells

  2010cites this paper
• The Protein Interaction Network of the Human Transcription Machinery Reveals a Role for the Conserved GTPase RPAP4/GPN1 and Microtubule Assembly in Nuclear Import and Biogenesis of RNA Polymerase II

  2010influential citation
• Spécificité de liaison et de répression de la « Methyl-CpG-Binding Domain protein 2 » (MBD2) : identification de gènes cibles impliqués dans les cancers

  2009cites this paper
• DNA Methylation in Breast Cancer

  2009cites this paper
• BDNF gene methylation in brain of suicide subjects

  2009cites this paper
• DNA demethylation and cancer metastasis: therapeutic implications

  2008cites this paper
• Genomic context analysis in Archaea suggests previously unrecognized links between DNA replication and translation

  2008cites this paper
• Demethylation of (Cytosine-5-C-methyl) DNA and regulation of transcription in the epigenetic pathways of cancer development

  2008cites this paper
• Positive histone marks are associated with active transcription from a methylated ICSBP/IRF8 gene.

  2008cites this paper
• Other proteins interacting with XP proteins.

  2008cites this paper
• Epigenetic Regulation of Gene Transcription in Hematopoietic Tumors

  2008influential citation
• Analyse des complexes protéiques interagissant avec la machinerie de l'ARN polymérase II dans les cellules humaines

  2008cites this paper
• The role of MBD3 and the cell cycle in the regulation of the epigenome

  2008cites this paper
• Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

  2007cites this paper
• Methyl-CpG Binding Domain Proteins and Their Involvement in the Regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 Gene Promoters

  2007cites this paper
• Structural insights into a new homodimeric self‐activated GTPase family

  2007cites this paper
• Epigenetic control of tumor suppression.

  2007cites this paper
• Epigenetic tête-à-tête: the bilateral relationship between chromatin modifications and DNA methylation.

  2006cites this paper
• TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters

  2006influential citation
• Halogenated thymidine analogues restore the expression of silenced genes without demethylation.

  2005cites this paper
• Methyl-CpG-binding proteins in cancer: blaming the DNA methylation messenger.

  2005cites this paper
• Activation of a Methylated Promoter Mediated by a Sequence-specific DNA-binding Protein, RFX*

  2005cites this paper
• Journal of Insect Science Expression, Purification and Characterization of Methyl Dna Binding Protein from Bombyx Mori

  2004cites this paper
• In vivo analysis of DNA methylation patterns recognized by specific proteins: coupling CHIP and bisulfite analysis.

  2004cites this paper
• Methylation and demethylation in the regulation of genes, cells, and responses in the immune system.

  2003cites this paper