Infection of human alveolar macrophages by human coronavirus strain 229E.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of General Virology

• Publication date

  2012-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1099/vir.0.038414-0PMID 22090214PMCID PMC3352353
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Innate immune response to influenza A virus in differentiated human alveolar type II cells.

  2011cited by this paper
• Cytokine production by primary human macrophages infected with highly pathogenic H5N1 or pandemic H1N1 2009 influenza viruses.

  2011cited by this paper
• Epidemiology and Clinical Presentations of the Four Human Coronaviruses 229E, HKU1, NL63, and OC43 Detected over 3 Years Using a Novel Multiplex Real-Time PCR Method

  2010cited by this paper
• Pandemic H1N1 Influenza A Viruses Are Resistant to the Antiviral Activities of Innate Immune Proteins of the Collectin and Pentraxin Superfamilies

  2010cited by this paper
• Role of surfactant protein A and D (SP-A and SP-D) in human antiviral host defense.

  2010cited by this paper
• Culturing the Unculturable: Human Coronavirus HKU1 Infects, Replicates, and Produces Progeny Virions in Human Ciliated Airway Epithelial Cell Cultures

  2010cited by this paper
• Differentiated Human Alveolar Type II Cells Secrete Antiviral IL-29 (IFN-λ1) in Response to Influenza A Infection1

  2009cited by this paper
• Unraveling the complexities of the interferon response during SARS-CoV infection.

  2009cited by this paper
• Rat respiratory coronavirus infection: replication in airway and alveolar epithelial cells and the innate immune response.

  2009cited by this paper
• Detection of four human coronaviruses in respiratory infections in children: A one‐year study in Colorado

  2009cited by this paper
• Human Coronaviruses 229E and NL63: Close Yet Still So Far

  2009cited by this paper
• The SARS Coronavirus 3a Protein Causes Endoplasmic Reticulum Stress and Induces Ligand-Independent Downregulation of the Type 1 Interferon Receptor

  2009cited by this paper
• Development of a Nucleocapsid-Based Human Coronavirus Immunoassay and Estimates of Individuals Exposed to Coronavirus in a U.S. Metropolitan Population

  2008cited by this paper
• Surfactant Collectins and Innate Immunity

  2008cited by this paper
• Severe Acute Respiratory Syndrome Coronavirus nsp1 Suppresses Host Gene Expression, Including That of Type I Interferon, in Infected Cells

  2008cited by this paper
• Cigarette smoke exposure attenuates cytokine production by mouse alveolar macrophages.

  2008cited by this paper
• Human airway epithelial cell culture to identify new respiratory viruses: Coronavirus NL63 as a model

  2008cited by this paper
• Differentiated human alveolar epithelial cells and reversibility of their phenotype in vitro.

  2007cited by this paper
• Clinical Disease in Children Associated With Newly Described Coronavirus Subtypes

  2007cited by this paper
• SARS-CoV replicates in primary human alveolar type II cell cultures but not in type I-like cells

  2007cited by this paper
• Tobacco Smoking Inhibits Expression of Proinflammatory Cytokines and Activation of IL-1R-Associated Kinase, p38, and NF-κB in Alveolar Macrophages Stimulated with TLR2 and TLR4 Agonists1

  2007cited by this paper
• Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.

  2007cited by this paper
• The SARS coronavirus spike glycoprotein is selectively recognized by lung surfactant protein D and activates macrophages

  2007cited by this paper
• Activation of human monocytes after infection by human coronavirus 229E

  2007cited by this paper
• Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame (ORF) 3b, ORF 6, and Nucleocapsid Proteins Function as Interferon Antagonists

  2006cited by this paper
• 7a Protein of Severe Acute Respiratory Syndrome Coronavirus Inhibits Cellular Protein Synthesis and Activates p38 Mitogen-Activated Protein Kinase

  2006cited by this paper
• The Novel Human Coronaviruses NL63 and HKU1

  2006cited by this paper
• Characterization and Complete Genome Sequence of a Novel Coronavirus, Coronavirus HKU1, from Patients with Pneumonia

  2005cited by this paper
• Granzyme B, a New Player in Activation-Induced Cell Death, Is Down-Regulated by Vasoactive Intestinal Peptide in Th2 but Not Th1 Effectors1

  2005cited by this paper
• Cytokine Responses in Severe Acute Respiratory Syndrome Coronavirus-Infected Macrophages In Vitro: Possible Relevance to Pathogenesis

  2005cited by this paper
• A previously undescribed coronavirus associated with respiratory disease in humans.

  2004cited by this paper
• Respiratory viral infections in patients with chronic, obstructive pulmonary disease

  2004cited by this paper
• Identification of a new human coronavirus

  2004cited by this paper
• Regulation of Airway Epithelial Cell NF-κB-Dependent Gene Expression by Protein Kinase Cδ1

  2003cited by this paper
• Erratum: Regulation of airway epithelial cell NF-κB-dependent gene expression by protein kinase Cδ (Journal of Immunology (2003) 170 (5681-5689))

  2003cited by this paper
• Regulation of airway epithelial cell NF-kappa B-dependent gene expression by protein kinase C delta.

  2003cited by this paper
• Coronavirus 229E-Related Pneumonia in Immunocompromised Patients

  2003cited by this paper
• A prospective, community-based study on virologic assessment among elderly people with and without symptoms of acute respiratory infection

  2003cited by this paper
• Alveolar epithelial type II cell: defender of the alveolus revisited

  2001cited by this paper
• Molecular Determinants of Species Specificity in the Coronavirus Receptor Aminopeptidase N (CD13): Influence of N-Linked Glycosylation

  2001cited by this paper
• Spectrum of Clinical Illness in Hospitalized Patients with “Common Cold” Virus Infections

  2000cited by this paper
• Human Coronavirus 229E Infects Polarized Airway Epithelia from the Apical Surface

  2000cited by this paper
• Mechanism of binding of surfactant protein D to influenza A viruses: importance of binding to haemagglutinin to antiviral activity.

  2000cited by this paper
• Pathogenesis of coronavirus-induced infections. Review of pathological and immunological aspects.

  1998cited by this paper
• Collectin-mediated antiviral host defense of the lung: evidence from influenza virus infection of mice

  1997cited by this paper
• CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells.

  1994cited by this paper
• Human aminopeptidase N is a receptor for human coronavirus 229E

  1992cited by this paper
• Coronavirus Infection in Acute Lower Respiratory Tract Disease of Infants

  1974cited by this paper

• Coronavirus infection and chronic lung allograft dysfunction: a retrospective cohort study.

  2025cites this paper
• Differential immunoregulation by human surfactant protein A variants determines severity of SARS-CoV-2-induced lung disease

  2025cites this paper
• Collectins and Ficolins.

  2025cites this paper
• UHRF1 restricts HCoV-229E infection through epigenetic silencing of the viral receptor APN

  2025cites this paper
• Interplay between respiratory viruses and cilia in the airways

  2025cites this paper
• Human Coronavirus-229E Hijacks Key Host-Cell RNA-Processing Complexes for Replication

  2025cites this paper
• Human surfactant protein A inhibits SARS-CoV-2 infectivity and alleviates lung injury in a mouse infection model

  2024cites this paper
• Do chemokine/chemokine receptor axes play paramount parts in trafficking and oriented locomotion of monocytes/macrophages toward the lungs of COVID-19 infected patients? A systematic review.

  2024cites this paper
• Utilizing network pharmacology and experimental validation to investigate the underlying mechanism of Denglao Qingguan decoction against HCoV-229E

  2024cites this paper
• Differential Immunoregulation by Human Surfactant Protein A Variants Determines Severity of SARS-CoV-2-induced Lung Disease

  2024cites this paper
• The Effects of Different Respiratory Viruses on the Oxidative Stress Marker Levels in an In Vitro Model: A Pilot Study

  2024cites this paper
• Surfactant Protein A Inhibits Human Rhinovirus C Binding and Infection of Airway Epithelial Cells from Pediatric Asthma

  2024cites this paper
• Host Cell Proteases Involved in Human Respiratory Viral Infections and Their Inhibitors: A Review

  2024cites this paper
• Paracrinal regulation of neutrophil functions by coronaviral infection in iPSC-derived alveolar type II epithelial cells

  2024cites this paper
• Pulmonary surfactant-derived antiviral actions at the respiratory surface

  2023cites this paper
• Human Surfactant Protein A Alleviates SARS-CoV-2 Infectivity in Human Lung Epithelial Cells

  2023influential citation
• Respuesta inmunitaria innata pulmonar en la infección por Sars-Cov-2

  2022cites this paper
• Malondialdehyde acetaldehyde adduction of surfactant protein D attenuates SARS‐CoV‐2 spike protein binding and virus neutralization

  2022cites this paper
• More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitro

  2022cites this paper
• Nonproductive exposure of PBMCs to SARS‐CoV‐2 induces cell‐intrinsic innate immune responses

  2022cites this paper
• Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs

  2022cites this paper
• Kathryn V. Holmes: A Career of Contributions to the Coronavirus Field

  2022cites this paper
• The role of surfactant proteins SP-A and SP-D in viral infection: a focus on COVID-19

  2022cites this paper
• Exercise-induced myokines downregulates the ACE2 level in bronchial epithelial cells: Implications for SARS-CoV-2 prevention

  2022cites this paper
• Insights Gained Into the Treatment of COVID19 by Pulmonary Surfactant and Its Components

  2022cites this paper
• Alveolar macrophages protect mice from MERS-CoV-induced pneumonia and severe disease

  2022cites this paper
• Antiviral therapy for COVID-19: Derivation of optimal strategy based on past antiviral and favipiravir experiences

  2022cites this paper
• Pulmonary surfactant as a versatile biomaterial to fight COVID-19

  2021cites this paper
• SP-A and SP-D: Dual Functioning Immune Molecules With Antiviral and Immunomodulatory Properties

  2021cites this paper
• Bovine Collectins: Role in Health and Disease

  2021cites this paper
• Biological Activities of SP-A and SP-D Against Extracellular and Intracellular Pathogens

  2021cites this paper
• Human Surfactant Protein D Binds Spike Protein and Acts as an Entry Inhibitor of SARS-CoV-2 Pseudotyped Viral Particles

  2021influential citation
• Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal coronaviruses

  2021influential citation
• Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs

  2021cites this paper
• Genome-Scale Metabolic Model of Infection with SARS-CoV-2 Mutants Confirms Guanylate Kinase as Robust Potential Antiviral Target

  2021cites this paper
• Susceptibility of different cell lines to the novel canine coronavirus CCoV‐HuPn‐2018

  2021cites this paper
• Monocytes and Macrophages in COVID-19

  2021cites this paper
• Improving human coronavirus OC43 (HCoV-OC43) research comparability in studies using HCoV-OC43 as a surrogate for SARS-CoV-2

  2021cites this paper
• SARS-CoV-2: Pathogenic Mechanisms and Host Immune Response.

  2021cites this paper
• Genome-Scale Metabolic Model of Infection with SARS-CoV-2 Mutants Confirms Guanylate Kinase as Robust Potential Antiviral Target

  2021cites this paper
• SP-A and SPD : dual functioning immune molecules with antiviral and 1 immunomodulatory properties 2

  2020cites this paper
• The relationship between human coronaviruses, asthma and allergy—An unresolved dilemma

  2020cites this paper
• Classification of the present pharmaceutical agents based on the possible effective mechanism on the COVID-19 infection

  2020cites this paper
• The molecular virology of coronaviruses

  2020cites this paper
• Acute inflammation and pathogenesis of SARS-CoV-2 infection: Cannabidiol as a potential anti-inflammatory treatment?

  2020cites this paper
• The collagen receptor uPARAP/Endo180 regulates collectins through unique structural elements in its FNII domain

  2020cites this paper
• Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells

  2020cites this paper
• Collectins: Innate Immune Pattern Recognition Molecules

  2020cites this paper
• A Recombinant Fragment of Human Surfactant Protein D Binds Spike Protein and Inhibits Infectivity and Replication of SARS-CoV-2 in Clinical Samples

  2020cites this paper
• Improved plaque assay for human coronaviruses 229E and OC43

  2020cites this paper
• FBA reveals guanylate kinase as a potential target for antiviral therapies against SARS-CoV-2

  2020cites this paper
• No Evidence for Human Monocyte-Derived Macrophage Infection and Antibody-Mediated Enhancement of SARS-CoV-2 Infection

  2020cites this paper
• Lectin in Host Defense Against Microbial Infections

  2020cites this paper
• Human Surfactant Protein D Binds S1 and Receptor Binding Domain of Spike protein and acts as an entry inhibitor of SARS-CoV-2 Pseudotyped viral particles in vitro

  2020cites this paper
• COVID-19: The Emerging Immunopathological Determinants for Recovery or Death

  2020cites this paper
• Características y especialización de la respuesta inmunitaria en la COVID-19

  2020cites this paper
• Targeting Macrophages as a Therapeutic Option in Coronavirus Disease 2019

  2020cites this paper
• Pathogenesis‐directed therapy of 2019 novel coronavirus disease

  2020cites this paper
• The Potential Role of Coagulation Factor Xa in the Pathophysiology of COVID-19: A Role for Anticoagulants as Multimodal Therapeutic Agents

  2020cites this paper
• Lung Secretoglobin Scgb1a1 Influences Alveolar Macrophage-Mediated Inflammation and Immunity

  2020cites this paper
• Phosphatidylglycerol and surfactant: A potential treatment for COVID-19?

  2020cites this paper
• Exploitation of glycosylation in enveloped virus pathobiology

  2019cites this paper
• Viral Respiratory Tract Infection During the First Postoperative Year Is a Risk Factor for Chronic Rejection After Lung Transplantation

  2018cites this paper
• MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cells

  2018cites this paper
• Human Coronaviruses: A Review of Virus–Host Interactions

  2016cites this paper
• Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte-derived macrophages and dendritic cells.

  2016cites this paper
• Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment.

  2013cites this paper
• Differential Cell Line Susceptibility to the Emerging Novel Human Betacoronavirus 2c EMC/2012: Implications for Disease Pathogenesis and Clinical Manifestation

  2013cites this paper
• The Human Coronavirus Nucleocapsid Protein and Its Effects on the Innate Immune Response

  2013cites this paper
• Human Coronavirus HKU1 Infection of Primary Human Type II Alveolar Epithelial Cells: Cytopathic Effects and Innate Immune Response

  2013cites this paper
• Innate immune response of human alveolar type II cells infected with severe acute respiratory syndrome-coronavirus.

  2013cites this paper
• 2c EMC/2012: implications on disease pathogenesis and clinical manifestation

  2013cites this paper
• Structure–function correlations of pulmonary surfactant protein SP-B and the saposin-like family of proteins

  2013cites this paper