Cell cycle block and apoptosis induction in a human melanoma cell line following treatment with 2‐methoxyoestradiol: therapeutic implications?

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Melanoma research

• Publication date

  2003-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1097/00008390-200304000-00003PMID 12690294
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• 2-Methoxyestradiol: an Endogenous Antiangiogenic and Antiproliferative Drug Candidate

  2004cited by this paper
• The physiological estrogen metabolite 2-methoxyestradiol reduces tumor growth and induces apoptosis in human solid tumors

  2001cited by this paper
• 2‐methoxyestradiol blocks cell‐cycle progression at G2/M phase and inhibits growth of human prostate cancer cells

  2001cited by this paper
• Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells.

  2000cited by this paper
• Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

  1999cited by this paper
• Calcitonin receptor-mediated growth suppression of HEK-293 cells is accompanied by induction of p21WAF1/CIP1 and G2/M arrest.

  1999cited by this paper
• Malignant melanoma: an update on treatments.

  1999cited by this paper
• Potent antitumor activity of 2-methoxyestradiol in human pancreatic cancer cell lines.

  1999cited by this paper
• Functional role of estrogen metabolism in target cells: review and perspectives.

  1998cited by this paper
• Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.

  1997cited by this paper
• Induction of apoptosis in human lung cancer cells after wild-type p53 activation by methoxyestradiol

  1997cited by this paper
• Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase.

  1997cited by this paper
• The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex

  1997cited by this paper
• The mammalian metabolite, 2-methoxyestradiol, affects P53 levels and apoptosis induction in transformed cells but not in normal cells.

  1997cited by this paper
• Human Myt1 Is a Cell Cycle-regulated Kinase That Inhibits Cdc2 but Not Cdk2 Activity*

  1997cited by this paper
• Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation.

  1995cited by this paper
• Regulation of the human WEE1Hu CDK tyrosine 15‐kinase during the cell cycle.

  1995cited by this paper
• Analysis of p53 in human cutaneous melanoma cell lines.

  1994cited by this paper
• Mutation and expression of the p53 gene in human malignant melanoma

  1994cited by this paper
• The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

  1994cited by this paper
• 2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

  1994cited by this paper
• Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15.

  1993cited by this paper
• P450 enzymes of estrogen metabolism.

  1993cited by this paper
• Effects of 17 beta-estradiol metabolites on cell cycle events in MCF-7 cells.

  1992cited by this paper
• Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase.

  1992cited by this paper
• A biochemical hallmark of apoptosis: Internucleosomal degradation of the genome

  1992cited by this paper
• Effects of 17β-Estradiol Metabolites on Cell Cycle Events in MCF-7 Cells

  1992cited by this paper
• Mutational analysis of the human p53 gene in malignant melanoma.

  1991cited by this paper
• Universal control mechanism regulating onset of M-phase

  1990cited by this paper
• The cytotoxic effects of estradiol-17 beta, catecholestradiols and methoxyestradiols on dividing MCF-7 and HeLa cells.

  1989cited by this paper
• Combination chemotherapy with cisplatin, carmustine, dacarbazine, and tamoxifen in metastatic melanoma.

  1984cited by this paper
• Sex steroid receptor analysis in human melanoma

  1980cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining

  1975cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper
• Studies on melanoma. II. Sex and survival in human melanoma.

  1959cited by this paper
• Studies on Melanoma

  1959cited by this paper

• The pivotal role of irradiation‐induced apoptosis in the pathogenesis and therapy of medulloblastoma

  2024cites this paper
• Cutaneous Melanoma and Hormones: Focus on Sex Differences and the Testis

  2022cites this paper
• Anticancer activity of chicken cathelicidin peptides against different types of cancer

  2021cites this paper
• A Review of Progesterone Effects on Human Melanoma Cell Growth In-Vitro

  2021cites this paper
• A survey of in-vitro and in-vivo effects of steroids on melanoma growth and its implication on the nature of the disease

  2020cites this paper
• Sex and Gender Disparities in Melanoma

  2020cites this paper
• The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKCδ signaling

  2020cites this paper
• Hormonal Regulation of Cutaneous Melanoma: A Brief Review of In Vivo and In Vitro Studies and Its Clinical Implication

  2019cites this paper
• 2-Methoxyestradiol and Its Combination with a Natural Compound, Ferulic Acid, Induces Melanoma Cell Death via Downregulation of Hsp60 and Hsp90

  2019cites this paper
• In-Vitro Effect of Steroids on Melanoma Cell Growth—A Prelude to Melanoma Treatment?

  2018cites this paper
• Biology and Sex Disparities in Melanoma Outcomes

  2018cites this paper
• Is Melanoma a Hormone-Dependent Cancer or a Hormone-Responsive Cancer?

  2018cites this paper
• 4‐Methylcatechol inhibits cell growth and testosterone production in TM3 Leydig cells by reducing mitochondrial activity

  2017cites this paper
• Inhibition of proliferation and invasion in 2D and 3D models by 2‐methoxyestradiol in human melanoma cells

  2017cites this paper
• 4‐Methylcatechol‐induced cell damage in TM4 Sertoli cells

  2015cites this paper
• Sex disparities in melanoma outcomes: the role of biology.

  2014cites this paper
• Associations between environmental factors and incidence of cutaneous melanoma. Review

  2012cites this paper
• Synthetic 2-methoxyestradiol derivatives: structure-activity relationships.

  2012cites this paper
• Critical role of cyclin B1/Cdc2 up-regulation in the induction of mitotic prometaphase arrest in human breast cancer cells treated with 2-methoxyestradiol.

  2012cites this paper
• 4-Methylcatechol-induced oxidative stress induces intrinsic apoptotic pathway in metastatic melanoma cells.

  2011cites this paper
• 2-Methoxyestradiol--biology and mechanism of action.

  2010cites this paper
• Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation.

  2009cites this paper
• Combination of 2-methoxyestradiol (2-ME2) and eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells.

  2009cites this paper
• Cytotoxic Effects of 2-Methoxyestradiol in the Hepatocellular Carcinoma Cell Line HepG2

  2009cites this paper
• 2-methoxyestradiol as a potential cytostatic drug in gliomas?

  2009cites this paper
• [Endocrine factors influencing melanoma progression].

  2009cites this paper
• 2-methoxyestradiol Prevents LNCaP Tumor Development in Nude Mice: Potential Role of G2/M Regulatory Proteins

  2009cites this paper
• Influence of 2-methoxyestradiol on MCF-7 cells: an improved differential interference contrasting technique and Bcl-2 and Bax protein expression levels.

  2009cites this paper
• Mechanisms of 2-methoxyestradiol-induced apoptosis and G2/M cell-cycle arrest of nasopharyngeal carcinoma cells.

  2008cites this paper
• 2‐methoxyestradiol‐induced cell death in osteosarcoma cells is preceded by cell cycle arrest

  2008cites this paper
• In vitro effects of 2‐methoxyestradiol on cell morphology and Cdc2 Kinase activity in SNO oesophageal carcinoma cells

  2007cites this paper
• Influence of 2-methoxyestradiol on cell morphology and cdc2 kinase activity in WHCO3 esophageal carcinoma cells.

  2007cites this paper
• Influence of prostaglandin A 2 on Bax , Bcl-2 and PCNA expression in MCF-7 cells

  2006cites this paper
• Influence of prostaglandin A2 on Bax, Bcl-2 and PCNA expression in MCF-7 cells.

  2006cites this paper
• Estrogen Metabolite 2-Methoxyestradiol Induces Apoptosis and Inhibits Cell Proliferation and Collagen Production in Rat and Human Leiomyoma Cells: A Potential Medicinal Treatment for Uterine Fibroids

  2006cites this paper
• Inhibition of MDA‐MB‐231 cell cycle progression and cell proliferation by C‐2‐substituted oestradiol mono‐ and bis‐3‐O‐sulphamates

  2005cites this paper
• Bax/Bcl-2 expression levels of 2-methoxyestradiol-exposed esophageal cancer cells.

  2005cites this paper
• Infl uence of prostaglandin A 2 and 2-methoxyestradiol on Bax and Bcl-2 expression levels in cervical carcinoma cells

  2005cites this paper
• Influence of prostaglandin A2 and 2-methoxyestradiol on Bax and Bcl-2 expression levels in cervical carcinoma cells.

  2005cites this paper
• Eugenol Causes Melanoma Growth Suppression through Inhibition of E2F1 Transcriptional Activity*

  2005cites this paper
• 2-methoxyestradiol enhances p53 protein transduction therapy-associated inhibition of the proliferation of oral cancer cells through the suppression of NFkappaB activity.

  2004cites this paper
• In vitro and in vivo antitumor effect of 2‐methoxyestradiol on human melanoma

  2004cites this paper
• New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent

  2003cites this paper
• 2-Methoxyestradiol interferes with NF kappa B transcriptional activity in primitive neuroectodermal brain tumors: implications for management.

  2003cites this paper
• Mechanism of action of 2-methoxyestradiol: new developments.

  2003cites this paper
• Modulation of mitogen-activated protein kinases by 6-nitro-7-hydroxycoumarin mediates apoptosis in renal carcinoma cells.

  2003cites this paper