Salivary protein candidates for biomarkers of oral disorders in alcohol and tobacco dependents.

OBJECTIVES To evaluate the oral condition of alcohol and tobacco dependents and identify salivary protein candidates for biomarkers of oral disorders. SUBJECTS AND METHODS Thirty-three male volunteers were evaluated for alcohol abuse rehabilitation; nine were selected for proteomic analysis. Intraoral examination was performed, and non-stimulated saliva was collected. Salivary proteins were extracted and processed for analysis. A list of proteins identified in saliva was generated from the database and manually revised, obtaining the total number of candidate biomarkers for oral disorders. RESULTS The mean age (n=33) was 42.94±8.61 years. 14(42.4%) subjects presented with 23 oral mucosa changes and 31(94%) had dental plaque. 282 proteins were found in saliva (n=9), of which 26 were identified as candidates for biomarkers of oral disorders. After manual review, 21 proteins were selected. The highest number of candidates for biomarkers was associated with Carcinoma of head and neck (n=10), Nasopharyngeal carcinoma (n=6) and Periodontal disease (n=6). CONCLUSION Alcohol and tobacco dependents showed gingival inflammation and less than half of them showed oral mucosa changes. 21 protein candidates for biomarkers of oral disorders were identified in saliva. The two major oral disorders in number of candidates for biomarkers were head and neck cancer and periodontal disease.

• Publication year

  2020

• Venue

  Oral Diseases

• Publication date

  2020-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/odi.13337PMID 32237000
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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