Letter to the editor in regards to fasting vs bedtime thyroxine ingestion

The recent meta-analysis by Pang et al.(1) exploring the effect of L-thyroxine administration before breakfast versus at bedtime concludes that either approach results in similar outcomes. This conclusion stands in stark contrast to another excellent study done examining the timing issues of Pre breakfast vs. with breakfast or at Bedtime (2). Bach-Huynh TG et al. clearly demonstrate the superiority of pre-breakfast LT4 ingestion when taken 60 minutes before the first meal of the day with significantly lower TSH values (mean 1.06+/-1.23 mIU/L pre and 2.19 +/- 2.66 at bedtime, p < 0.001). Additionally they observe greater variability of TSH outcomes when the LT4 is taken at bedtime where 35% of TSH values were more than 1 mIU/L greater than the 60 minute fasting values and only 63% of TSH values were less than 1 mIU/L different.

• Publication year

  2020

• Venue

  Clinical Endocrinology

• Publication date

  2020-04-03

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/cen.14186PMID 32242957
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of l‐thyroxine administration before breakfast vs at bedtime on hypothyroidism: A meta‐analysis

  2020cited by this paper
• Timing of levothyroxine administration affects serum thyrotropin concentration.

  2009cited by this paper

• No citing papers are available for this paper.