Sleeping Sickness Pathogen (Trypanosoma brucei) and Natural Products: Therapeutic Targets and Screening Systems

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Planta Medica

• Publication date

  2010-10-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1055/s-0030-1250411PMID 20945274
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Diseases

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• World Health Organisation

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• Enhancement of the biological activity of adenosine analogs by the adenosine deaminase inhibitor 2'-deoxycoformycin.

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