17α-Ethynylestradiol alters the immune response of the teleost gilthead seabream (Sparus aurata L.) both in vivo and in vitro.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Developmental and Comparative Immunology

• Publication date

  2012-03-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.dci.2011.09.011PMID 22020196
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Behavioral and genomic impacts of a wastewater effluent on the fathead minnow.

  2011influential reference
• The effects of estrogenic and androgenic endocrine disruptors on the immune system of fish: a review

  2011cited by this paper
• Estrogen-responsive genes in macrophages of the bony fish gilthead seabream: a transcriptomic approach.

  2011cited by this paper
• Dietary intake of 17α-ethinylestradiol promotes leukocytes infiltration in the gonad of the hermaphrodite gilthead seabream.

  2011cited by this paper
• 17Beta-estradiol affects the response of complement components and survival of rainbow trout (Oncorhynchus mykiss) challenged by bacterial infection.

  2011cited by this paper
• 17β-Estradiol regulates gilthead seabream professional phagocyte responses through macrophage activation.

  2011cited by this paper
• Effects of 17α‐ethynylestradiol and nonylphenol on liver and gonadal apoptosis and histopathology in Chalcalburnus tarichi

  2011cited by this paper
• Modulation of steroidogenesis and estrogen signalling in the estuarine killifish (Fundulus heteroclitus) exposed to ethinylestradiol.

  2010cited by this paper
• Sex- and tissue-specific effects of waterborne estrogen on estrogen receptor subtypes and E2-mediated gene expression in the reproductive axis of goldfish.

  2010cited by this paper
• Effect of endocrine disrupting chemicals on the transcription of genes related to the innate immune system in the early developmental stage of zebrafish (Danio rerio).

  2010cited by this paper
• An integrated transcriptomic and proteomic approach characterizing estrogenic and metabolic effects of 17 alpha-ethinylestradiol in zebrafish (Danio rerio).

  2010cited by this paper
• Challenge with 17alpha-ethinylestradiol (EE2) during early development persistently impairs growth, differentiation, and local expression of IGF-I and IGF-II in immune organs of tilapia.

  2009cited by this paper
• Disruption of sexual selection in sand gobies (Pomatoschistus minutus) by 17alpha-ethinyl estradiol, an endocrine disruptor.

  2009cited by this paper
• Effects of Ethinylestradiol on Medaka (Oryzias latipes) as Measured by Sperm Motility and Fertilization Success

  2009cited by this paper
• Fish Defenses Vol. 1 : Immunology

  2009cited by this paper
• Altered sexual development in roach (Rutilus rutilus) exposed to environmental concentrations of the pharmaceutical 17alpha-ethinylestradiol and associated expression dynamics of aromatases and estrogen receptors.

  2008cited by this paper
• Sex steroids and metabolic parameter levels in a seasonal breeding fish (Sparus aurata L.).

  2008cited by this paper
• Estrogens, estrogen receptors and their role as immunoregulators in fish.

  2008cited by this paper
• Exposure to 17alpha-ethynylestradiol impairs reproductive functions of both male and female zebrafish (Danio rerio).

  2008cited by this paper
• 17Beta-Estradiol Triggers Postspawning in Spermatogenically Active Gilthead Seabream (Sparus aurata L.) Males1

  2007cited by this paper
• Health Impacts of Estrogens in the Environment, Considering Complex Mixture Effects

  2007cited by this paper
• Comparative Immunological Effects of a Natural Estrogen (17β-estradiol) versus a Pharmacologic Synthetic Estrogen (17α-ethinyl estradiol)

  2007cited by this paper
• Effects on reproductive potential and endocrine status in the mummichog (Fundulus heteroclitus) after exposure to 17alpha-ethynylestradiol in a short-term reproductive bioassay.

  2007cited by this paper
• Microarray analysis in the zebrafish (Danio rerio) liver and telencephalon after exposure to low concentration of 17alpha-ethinylestradiol.

  2007cited by this paper
• The complex role of estrogens in inflammation.

  2007influential reference
• Reduced embryonic survival in rainbow trout resulting from paternal exposure to the environmental estrogen 17alpha-ethynylestradiol during late sexual maturation.

  2007cited by this paper
• Collapse of a fish population after exposure to a synthetic estrogen

  2007cited by this paper
• Lessons from endocrine disruption and their application to other issues concerning trace organics in the aquatic environment.

  2006cited by this paper
• The colony-stimulating factor-1 receptor is a specific marker of macrophages from the bony fish gilthead seabream.

  2006cited by this paper
• Monocyte–Macrophage System as a Target for Estrogen and Selective Estrogen Receptor Modulators

  2006cited by this paper
• Characterization of estrogen receptor betab in sea bream (Sparus auratus): phylogeny, ligand-binding, and comparative analysis of expression.

  2006influential reference
• Field study using two immunoassays for the determination of estradiol and ethinylestradiol in the aquatic environment.

  2006cited by this paper
• Comparing steroid estrogen, and nonylphenol content across a range of European sewage plants with different treatment and management practices.

  2005cited by this paper
• Professional phagocytic granulocytes of the bony fish gilthead seabream display functional adaptation to testicular microenvironment

  2005cited by this paper
• Relationship between ethinylestradiol‐mediated changes in endocrine function and reproductive impairment in Japanese medaka (Oryzias latipes)

  2005cited by this paper
• An Overview of Cell Renewal in the Testis Throughout the Reproductive Cycle of a Seasonal Breeding Teleost, the Gilthead Seabream (Sparus aurata L)1

  2005cited by this paper
• Long-Term Exposure to Environmental Concentrations of the Pharmaceutical Ethynylestradiol Causes Reproductive Failure in Fish

  2004cited by this paper
• A role for acidophilic granulocytes in the testis of the gilthead seabream (Sparus aurata L., Teleostei).

  2003cited by this paper
• Sorption and degradation of selected five endocrine disrupting chemicals in aquifer material.

  2003cited by this paper
• Relative potencies and combination effects of steroidal estrogens in fish.

  2003cited by this paper
• Comparison of in vivo and in vitro reporter gene assays for short-term screening of estrogenic activity.

  2002cited by this paper
• Prediction of the bioaccumulation factors and body burden of natural and synthetic estrogens in aquatic organisms in the river systems.

  2002cited by this paper
• The Effects of Natural and Synthetic Steroid Estrogens in Relation to their Environmental Occurrence

  2002cited by this paper
• Evaluation of immune functions of rainbow trout (Oncorhynchus mykiss)--how can environmental influences be detected?

  2002cited by this paper
• Differential in vitro suppressive effects of steroids on leukocyte phagocytosis in two teleosts, tilapia and common carp.

  2001cited by this paper
• Ecotoxicology and innate immunity in fish.

  2001cited by this paper
• Effects of estradiol, progesterone and testosterone on the function of carp, Cyprinus carpio, phagocytes in vitro.

  2001cited by this paper
• A fish cell surface receptor defined by a mAb mediates leukocyte aggregation and deactivation.

  2001cited by this paper
• The immune system as a potential target for environmental estrogens (endocrine disrupters): a new emerging field.

  2000cited by this paper
• Development and validation of an enzyme immunoassay for testosterone: Effects of photoperiod on plasma testosterone levels and gonadal development in male sea bass (Dicentrarchus labrax, L.) at puberty

  2000cited by this paper
• Monitoring Natural and Synthetic Estrogens at Activated Sludge Sewage Treatment Plants and in a Receiving River Water

  2000cited by this paper
• Health Effects of Endocrine-Disrupting Chemicals on Wildlife, with Special Reference to the European Situation

  2000cited by this paper
• ETHINYLOESTRADIOL - AN UNDESIRED FISH CONTRACEPTIVE

  1999cited by this paper
• Effects of steroid hormones on immunoglobulin M (IgM) in rainbow trout, Oncorhynchus mykiss

  1999cited by this paper
• Analytical Methods for Detection of Selected Estrogenic Compounds in Aqueous Mixtures

  1999cited by this paper
• Behaviour and occurrence of estrogens in municipal sewage treatment plants--II. Aerobic batch experiments with activated sludge.

  1999influential reference
• Endocrine disruption in wildlife: a critical review of the evidence.

  1998cited by this paper
• Identification of Estrogenic Chemicals in STW Effluent. 1. Chemical Fractionation and in Vitro Biological Screening

  1998influential reference
• Identification of Estrogenic Chemicals in STW Effluent. 2. In Vivo Responses in Trout and Roach

  1998influential reference
• Methodological aspects of assessing phagocytosis of Vibrio anguillarum by leucocytes of gilthead seabream (Sparus aurata L.) by flow cytometry and electron microscopy

  1998cited by this paper
• Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment.

  1995influential reference
• Estradiol increases susceptibility of goldfish to Trypanosoma danilewskyi.

  1994cited by this paper
• Developmental effects of endocrine-disrupting chemicals in wildlife and humans.

  1993cited by this paper
• Reproductive Biology and Endocrinology Open Access in Vitro Secretion Profiles of Interleukin (il)-1beta, Il-6, Il-8, Il-10, and Tnf Alpha after Selective Infection with Escherichia Coli in Human Fetal Membranes

  year unknowncited by this paper

• Integrated Use of Oxidative Stress and Histological Biomarkers of T. tinca as Indicators of 17‐Alpha‐Ethynylestradiol Exposure

  2025cites this paper
• Endocrine disrupters affect the immune system of fish: the example of the European seabass.

  2025cites this paper
• Impact of endocrine disruptors on peripheral blood mononuclear cells in vitro: role of gender

  2023cites this paper
• Multigenerational impacts of EE2 on reproductive fitness and immune competence of marine medaka.

  2023cites this paper
• Crosstalk between reproductive and immune systems: the teleostean perspective.

  2022cites this paper
• Assessing Fish Immunotoxicity by Means of In Vitro Assays: Are We There Yet?

  2022cites this paper
• Acute exposure to 17-α-ethinylestradiol disrupt the embryonic development and oxidative status of Danio rerio.

  2021cites this paper
• Behavioral, physiological and biochemical responses and differential gene expression in Mytilus galloprovincialis exposed to 17 alpha-ethinylestradiol and sodium lauryl sulfate.

  2021cites this paper
• Estrogens as immunotoxicants: 17α-ethinylestradiol exposure retards thymus development in zebrafish (Danio rerio).

  2021cites this paper
• Xenosteroids in aquaculture with special consideration to Lake Manzala (Northern delta lake, Egypt): Types, sources and mechanism of action

  2021cites this paper
• Vaccination of Gilthead Seabream After Continuous Xenoestrogen Oral Exposure Enhances the Gut Endobolome and Immune Status via GPER1

  2021cites this paper
• The influence of 17β-oestradiol on lymphopoiesis and immune system ontogenesis in juvenile sea bass, Dicentrarchus labrax.

  2021cites this paper
• Evaluation of an in vitro assay to screen for the immunotoxic potential of chemicals to fish

  2021cites this paper
• Recent progress in screen-printed electrochemical sensors and biosensors for the detection of estrogens

  2021cites this paper
• The ERβ-CXCL19/CXCR4-NFκB pathway is critical in mediating the E2-induced inflammation response in the orange-spotted grouper (Epinephelus coioides).

  2021cites this paper
• An In Silico and In Vitro study for Investigating Estrogenic Endocrine Effects of Emerging Persistent Pollutants using Primary Hepatocytes from Grey Mullet (Mugil Cephalus)

  2021cites this paper
• Endocrine disrupter chemicals affect the humoral antimicrobial activities of gilthead seabream males even upon the cease of the exposure

  2020cites this paper
• Voltammetric determination of ethinylestradiol using screen-printed electrode modified with functionalized graphene, graphene quantum dots and magnetic nanoparticles coated with molecularly imprinted polymers.

  2020cites this paper
• 17α-ethinylestradiol and 4-tert-octylphenol concurrently disrupt the immune response of common carp.

  2020cites this paper
• G protein-coupled estrogen receptor 1 mediates estrogen effect in red common carp (Cyprinus carpio).

  2020cites this paper
• Long-term exposure to low 17α-ethinylestradiol (EE2) concentrations disrupts both the reproductive and the immune system of juvenile rainbow trout, Oncorhynchus mykiss.

  2020cites this paper
• 17β-Estradiol affects the innate immune response in common carp

  2020cites this paper
• Oestrogen differentially modulates lymphoid and myeloid cells of the European sea bass in vitro by specifically regulating their redox biology

  2019cites this paper
• Transcriptomic analysis of the impacts of ethinylestradiol (EE2) and its consequences for proliferative kidney disease outcome in rainbow trout (Oncorhynchus mykiss).

  2019cites this paper
• Aluminum adjuvant potentiates gilthead seabream immune responses but induces toxicity in splenic melanomacrophage centers.

  2019cites this paper
• Sex steroids exert a suppressive effect on innate and cell mediated immune responses in fresh water teleost, Channa punctatus.

  2019cites this paper
• Immune response of juvenile common carp (Cyprinus carpio L.) exposed to a mixture of sewage chemicals

  2019cites this paper
• The transcriptional regulation of an antimicrobial peptide hepcidin1 in Oryzias melastigma upon EE2 exposure involved in a new pathway with a novel transcriptional regulatory element HepERE

  2018cites this paper
• Effects of Sex Steroids on Fish Leukocytes

  2018cites this paper
• A description of liver and blood changes in matrinxã (Brycon amazonicus) during induced spawning

  2018cites this paper
• Sex-specific immunomodulatory action of the environmentalestrogen 17α-ethynylestradiol alongside with reproductive impairment in fish.

  2018cites this paper
• Hormones and fish monosex farming: A spotlight on immunity.

  2018cites this paper
• Role of estrogens in fish immunity with special emphasis on GPER1.

  2018cites this paper
• The extent to which immunity, apoptosis and detoxification gene expression interact with 17 alpha‐methyltestosterone

  2017cites this paper
• Stress differentially affects the systemic and leukocyte estrogen network in common carp

  2017cites this paper
• Alterations of gene expression indicating effects on estrogen signaling and lipid homeostasis in seabream hepatocytes exposed to extracts of seawater sampled from a coastal area of the central Adriatic Sea (Italy).

  2017cites this paper
• Estrogen-dependent seasonal adaptations in the immune response of fish.

  2017cites this paper
• The immunomodulatory role of the hypothalamus-pituitary-gonad axis: Proximate mechanism for reproduction-immune trade offs?

  2017cites this paper
• Estrogens Promote the Production of Natural Neutralizing Antibodies in Fish through G Protein-Coupled Estrogen Receptor 1

  2017cites this paper
• A role for multiple estrogen receptors in immune regulation of common carp

  2017cites this paper
• 17&agr;‐Ethynylestradiol alters the peritoneal immune response of gilthead seabream

  2017cites this paper
• 20 Years of fish immunotoxicology – what we know and where we are

  2017cites this paper
• Neuroendocrine-immune interaction: Evolutionarily conserved mechanisms that maintain allostasis in an ever-changing environment.

  2017cites this paper
• Water Oxygen Content Affects Distribution of T and B Lymphocytes in Lymphoid Tissues of Farmed Sea Bass (Dicentrarchus Labrax)

  2017cites this paper
• Enhanced content bio-imaging tools: realising the potential for high-throughput zebrafish bioassays

  2017cites this paper
• Degradation of 17α-Etinylestradiol by Nano-sized Zero Valent Iron

  2017cites this paper
• Quantitative investigation of the mechanisms of microplastics and nanoplastics toward zebrafish larvae locomotor activity.

  2017cites this paper
• Oxidative stress and immune disturbance after long-term exposure to bisphenol A in juvenile common carp (Cyprinus carpio).

  2016cites this paper
• Estrogen regulation of gene expression in the teleost fish immune system.

  2016cites this paper
• Selective estrogen receptor modulators differentially alter the immune response of gilthead seabream juveniles.

  2016cites this paper
• High contaminant loads in Lake Apopka's riparian wetland disrupt gene networks involved in reproduction and immune function in largemouth bass.

  2016cites this paper
• Effects of Endocrine Disruptors Chemicals on the immune response of gilthead seabream (Sparus aurata L.)

  2016cites this paper
• Tamoxifen disrupts the immune response of gilthead seabream (Sparus aurata L.)

  2015cites this paper
• Estrogenic Endocrine-Disrupting Chemicals Modulate the Production of Inflammatory Mediators and Cell Viability of Lipopolysaccharide-Stimulated Macrophages

  2015cites this paper
• Characterization of the effect of Cr(VI) on humoral innate immunity using Drosophila melanogaster

  2015cites this paper
• Tamoxifen persistently disrupts the humoral adaptive immune response of gilthead seabream (Sparus aurata L.).

  2015cites this paper
• Effects of Endocrine Disruptor Compounds, Alone or in Combination, on Human Macrophage-Like THP-1 Cell Response

  2015cites this paper
• Estrogen receptor 2b deficiency impairs the antiviral response of zebrafish.

  2015cites this paper
• The in vitro immune modulatory effect of bisphenol A on fish macrophages via estrogen receptor α and nuclear factor-κB signaling.

  2015cites this paper
• Dietary exposure of 17-alpha ethinylestradiol modulates physiological endpoints and gene signaling pathways in female largemouth bass (Micropterus salmoides).

  2014cites this paper
• Occurrence of 17α-ethynylestradiol (EE2) in the environment and effect on exposed biota: a review.

  2014cites this paper
• Influence of short-term exposure to low levels of 17α-ethynylestradiol on expression of genes involved in immunity and on immune parameters in rainbow trout, Oncorhynchus mykiss.

  2014cites this paper
• Developmental oestrogen exposure differentially modulates IGF-I and TNF-α expression levels in immune organs of Yersinia ruckeri-challenged young adult rainbow trout (Oncorhynchus mykiss).

  2014cites this paper
• Detection of immunotoxic effects of estrogenic and androgenic endocrine disrupting compounds using splenic immune cells of the female three-spined stickleback, Gasterosteus aculeatus (L.).

  2014cites this paper
• Fish granulocytes express a constitutively active androgen receptor variant.

  2014cites this paper
• Isolation of mast cells from the peritoneal exudate of the teleost fish gilthead sea bream (Sparus aurata L.).

  2014cites this paper
• Impact of environmental estrogens on Yfish considering the diversity of estrogen signaling.

  2013cites this paper
• Molecular crosstalk between a chemical and a biological stressor and consequences on disease manifestation in rainbow trout.

  2013cites this paper
• In situ forming microparticle implants for delivery of sex steroids in fish: Modulation of the immune response of gilthead seabream by testosterone.

  2013cites this paper
• The Effect of 17α-Ethynylestradiol on Steroidogenesis and Gonadal Cytokine Gene Expression Is Related to the Reproductive Stage in Marine Hermaphrodite Fish

  2013cites this paper
• Estrogen Signaling through the G Protein–Coupled Estrogen Receptor Regulates Granulocyte Activation in Fish

  2013cites this paper
• Acidophilic granulocytes in the gills of gilthead seabream Sparus aurata: evidence for their responses to a natural infection by a copepod ectoparasite

  2013cites this paper
• 17β-Estradiol induces changes in cytokine levels in head kidney and blood of juvenile sea bass (Dicentrarchus labrax, L., 1758).

  2013cites this paper
• Endocrine-Disrupting Chemical Exposure and the American Alligator: A Review of the Potential Role of Environmental Estrogens on the Immune System of a Top Trophic Carnivore

  2013cites this paper
• In vitro immunotoxicity of untreated and treated urban wastewaters using various treatment processes to rainbow trout leucocytes.

  2013cites this paper
• Modulation of leukocytic populations of gilthead sea bream (Sparus aurata) by the intestinal parasite Enteromyxum leei (Myxozoa: Myxosporea)

  2013cites this paper
• Estrogen Modulates Hepatic Gene Expression and Survival of Rainbow Trout Infected with Pathogenic Bacteria Yersinia ruckeri

  2012cites this paper