Host STAT2/type I interferon axis controls tumor growth

No abstract is available for this paper.

• Publication year

  2015

• Venue

  International Journal of Cancer

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/ijc.29004PMID 24895110PMCID PMC4199898
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cutaneous Tumors Cease CXCL9/Mig Production as a Result of IFN-γ–Mediated Immunoediting

  2013cited by this paper
• Interferon γ-induced intratumoral expression of CXCL9 alters the local distribution of T cells following immunotherapy with Listeria monocytogenes

  2013cited by this paper
• MicroRNA-146a Feedback Suppresses T Cell Immune Function by Targeting Stat1 in Patients with Chronic Hepatitis B

  2013cited by this paper
• Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells

  2011cited by this paper
• Intertissue Flow of Glutathione (GSH) as a Tumor Growth-promoting Mechanism

  2011cited by this paper
• Type I interferon is selectively required by dendritic cells for immune rejection of tumors

  2011cited by this paper
• Determinants of Successful CD8+ T-Cell Adoptive Immunotherapy for Large Established Tumors in Mice

  2011cited by this paper
• Control of Type I Interferon-induced Cell Death by Orai1-mediated Calcium Entry in T Cells*

  2011cited by this paper
• The efficacy of radiotherapy relies upon induction of type i interferon-dependent innate and adaptive immunity.

  2011cited by this paper
• Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo

  2011cited by this paper
• STAT2 Contributes to Promotion of Colorectal and Skin Carcinogenesis

  2010cited by this paper
• Resistance to IFN-α–Induced Apoptosis Is Linked to a Loss of STAT2

  2010cited by this paper
• Interferons Direct an Effective Innate Response to Legionella pneumophila Infection*

  2009cited by this paper
• Interferon-resistant Daudi Cell Line with a Stat2 Defect Is Resistant to Apoptosis Induced by Chemotherapeutic Agents*

  2009cited by this paper
• IFN-α Enhances Peptide Vaccine-Induced CD8+ T Cell Numbers, Effector Function, and Antitumor Activity1

  2009cited by this paper
• STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response

  2009influential reference
• Analysis of Gene Expression Data Using BRB-Array Tools

  2007cited by this paper
• Type I IFN Contributes to NK Cell Homeostasis, Activation, and Antitumor Function1

  2007cited by this paper
• IL-4 Suppresses Dendritic Cell Response to Type I Interferons1

  2007cited by this paper
• The interferon‐inducible gene, Ifi204, is transcriptionally activated in response to M‐CSF, and its expression favors macrophage differentiation in myeloid progenitor cells

  2006cited by this paper
• Type I interferon dependence of plasmacytoid dendritic cell activation and migration

  2005cited by this paper
• Stat1 and Stat2 but Not Stat3 Arbitrate Contradictory Growth Signals Elicited by Alpha/Beta Interferon in T Lymphocytes

  2005cited by this paper
• A critical function for type I interferons in cancer immunoediting

  2005cited by this paper
• Interferon-alphaCon1 suppresses proliferation of liver cancer cell lines in vitro and in vivo.

  2004cited by this paper
• Antiproliferative Effects of Interferon-αCon1 on Ovarian Clear Cell Adenocarcinoma In vitro and In vivo

  2004cited by this paper
• Failed Adoptive Immunotherapy with Tumor-Specific T Cells

  2004cited by this paper
• Interferon-αCon1 suppresses proliferation of liver cancer cell lines in vitro and in vivo

  2004cited by this paper
• The antitumor effects of IFN-alpha are abrogated in a STAT1-deficient mouse.

  2003cited by this paper
• The antitumor effects of IFN-α are abrogated in a STAT1-deficient mouse

  2003cited by this paper
• Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells

  2003cited by this paper
• Dominant negative signal transducer and activator of transcription 2 (STAT2) protein: stable expression blocks interferon alpha action in skin squamous cell carcinoma cells.

  2003influential reference
• Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain.

  2003cited by this paper
• Signalling: STATs: transcriptional control and biological impact

  2002cited by this paper
• Enhanced Tumor Development in Mice Lacking a Functional Type I Interferon Receptor

  2002cited by this paper
• Type I interferons produced by dendritic cells promote their phenotypic and functional activation.

  2002cited by this paper
• IFN‐α2a induces IP‐10/CXCL10 and MIG/CXCL9 production in monocyte‐derived dendritic cells and enhances their capacity to attract and stimulate CD8+ effector T cells

  2002cited by this paper
• Suppression of Type I Interferon Signaling Proteins Is an Early Event in Squamous Skin Carcinogenesis 1

  2002cited by this paper
• Suppression of type I interferon signaling proteins is an early event in squamous skin carcinogenesis.

  2002cited by this paper
• IFN-alpha2a induces IP-10/CXCL10 and MIG/CXCL9 production in monocyte-derived dendritic cells and enhances their capacity to attract and stimulate CD8+ effector T cells.

  2002cited by this paper
• Vanadate Facilitates Interferon α-mediated Apoptosis That Is Dependent on the Jak/Stat Pathway*

  2001cited by this paper
• Vanadate facilitates interferon alpha-mediated apoptosis that is dependent on the Jak/Stat pathway.

  2001cited by this paper
• Immune response in Stat2 knockout mice.

  2000cited by this paper
• How cells respond to interferons.

  1998cited by this paper
• Inhibition of cell proliferation by the interferon-inducible 204 gene, a member of the Ifi 200 cluster

  1998cited by this paper
• Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.

  1994cited by this paper
• Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor.

  1992cited by this paper
• The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.

  1992cited by this paper

• Conditional Stat2 Knockout Mice as a Platform for Modeling Human Diseases

  2026influential citation
• Dual STAT3/STAT5 inhibition as a novel treatment strategy in T-prolymphocytic leukemia

  2025cites this paper
• Raspberry ketone alleviates radiation-induced lung injury through the STAT2-P2X7r/NLRP3 signaling pathway.

  2025cites this paper
• Immune intrinsic escape signature stratifies prognosis, characterizes the tumor immune microenvironment, and identifies tumorigenic PPP1R8 in glioblastoma multiforme patients

  2025cites this paper
• Intron retention regulates STAT2 function and predicts immunotherapy response in lung cancer

  2025cites this paper
• STAT2 Promotes Tumor Growth in Colorectal Cancer Independent of Type I IFN Receptor Signaling

  2025cites this paper
• Interferons in Colorectal Cancer Pathogenesis and Therapy

  2024cites this paper
• STAT3 drives the malignant progression of low-grade gliomas through modulating the expression of STAT1, FOXO1, and MYC

  2024influential citation
• STAT2 negatively regulates RIG-I in the antiviral innate immunity of black carp.

  2024cites this paper
• STAT2 Controls Colorectal Tumorigenesis and Resistance to Anti-Cancer Drugs

  2023cites this paper
• STATs signaling pathways in dendritic cells: As potential therapeutic targets?

  2023cites this paper
• Antigen cross-presentation in dendric cells: From bench to bedside.

  2023cites this paper
• Lung cancer treatment potential and limits associated with the STAT family of transcription factors.

  2023cites this paper
• High Expression of Interferon Pathway Genes CXCL10 and STAT2 Is Associated with Activated T-Cell Signature and Better Outcome of Oral Cancer Patients

  2022cites this paper
• Exposing the Two Contrasting Faces of STAT2 in Inflammation

  2022cites this paper
• The duality of STAT2 mediated type I interferon signaling in the tumor microenvironment and chemoresistance

  2022cites this paper
• Mining the prognostic significance and immune infiltration of STAT family members in human breast cancer by bioinformatics analysis.

  2021cites this paper
• GINS2 attenuates the development of lung cancer by inhibiting the STAT signaling pathway

  2021cites this paper
• Multi-omics analysis for potential inflammation-related genes involved in tumour immune evasion via extended application of epigenetic data

  2021cites this paper
• Identifying Infliximab- (IFX-) Responsive Blood Signatures for the Treatment of Rheumatoid Arthritis

  2021cites this paper
• Targeted Stat2 deletion in conventional dendritic cells impairs CTL responses but does not affect antibody production

  2020cites this paper
• The potential and controversy of targeting STAT family members in cancer.

  2020cites this paper
• Downregulation of RIG-I mediated by ITGB3/c-SRC/STAT3 signaling confers resistance to interferon-α-induced apoptosis in tumor-repopulating cells of melanoma

  2020cites this paper
• Interferon-β sensitizes human glioblastoma cells to the cyclin-dependent kinase inhibitor, TG02

  2020cites this paper
• [High expression of STAT2 in ovarian cancer and its effect on metastasis of ovarian cancer cells].

  2020cites this paper
• Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins

  2020cites this paper
• Interferons α and β in cancer: therapeutic opportunities from new insights

  2019cites this paper
• JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation

  2019cites this paper
• IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners

  2019cites this paper
• Chapter 2 STAT Proteins in Cancer

  2019cites this paper
• Expression profile and prognostic values of STAT family members in non-small cell lung cancer.

  2019cites this paper
• The interaction of type 1 and 2 interferons with neutrophils in Juvenile-onset Systemic Lupus Erythematosus

  2018cites this paper
• Genomic profiles of lung cancer associated with idiopathic pulmonary fibrosis

  2018cites this paper
• Dynamic Nuclear Polarization of 13 C Nuclei in the Liquid State over a 10 Tesla Field Range.

  2018cites this paper
• Dysregulation of miR-605-5p/STAT2 axis predicts an unfavorable survival in patients with gastric cancer

  2018cites this paper
• STAT2 (Signal Transducer and Activator of Transcription 2)

  2017cites this paper
• STAT Proteins in Cancer

  2016cites this paper
• STAT2 Is Required for TLR-Induced Murine Dendritic Cell Activation and Cross-Presentation

  2016cites this paper
• Transcriptional repression of IFNβ1 by ATF2 confers melanoma resistance to therapy

  2015cites this paper
• Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review

  2015cites this paper
• STAT 2 ( Signal Transducer and Activator of Transcription 2 )

  year unknowncites this paper
• Creating a STAT2 Knock-Out Rat With CRISPR/Cas9 Using i-Creating a STAT2 Knock-Out Rat With CRISPR/Cas9 Using i-GONAD GONAD

  year unknowncites this paper