E2F7 Is a Potent Inhibitor of Liver Tumor Growth in Adult Mice

Up‐regulation of the E2F‐dependent transcriptional network has been identified in nearly every human malignancy and is an important driver of tumorigenesis. Two members of the E2F family, E2F7 and E2F8, are potent repressors of E2F‐dependent transcription. They are atypical in that they do not bind to dimerization partner proteins and are not controlled by retinoblastoma protein. The physiological relevance of E2F7 and E2F8 remains incompletely understood, largely because tools to manipulate their activity in vivo have been lacking.

• Publication year

  2020

• Venue

  Hepatology

• Publication date

  2020-04-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/hep.31259PMID 32259305PMCID 7898887
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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