From Anonymous to Public Enemy: How Does a Mosquito Become a Feared Arbovirus Vector?

The past few decades have seen the emergence of several worldwide arbovirus epidemics (chikungunya, Zika), the expansion or recrudescence of historical arboviruses (dengue, yellow fever), and the modification of the distribution area of major vector mosquitoes such as Aedes aegypti and Ae. albopictus, raising questions about the risk of appearance of new vectors and new epidemics. In this opinion piece, we review the factors that led to the emergence of yellow fever in the Americas, define the conditions for a mosquito to become a vector, analyse the recent example of the new status of Aedes albopictus from neglected mosquito to major vector, and propose some scenarios for the future.

• Publication year

  2020

• Venue

  Pathogens

• Publication date

  2020-04-01

• Fields of study

  Geography, Medicine, Environmental Science

• Identifiers
  DOI 10.3390/pathogens9040265PMID 32260491PMCID 7238163
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2019influential reference
• An Evolutionary Perspective on Vector-Borne Diseases

  2019cited by this paper
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  2019cited by this paper
• Human Activities Attract Harmful Mosquitoes in a Tropical Urban Landscape

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• Twenty years of West Nile virus spread and evolution in the Americas visualized by Nextstrain

  2019cited by this paper
• GloPID-R report on chikungunya , o ' nyong-nyong and Mayaro virus , part 2 : Epidemiological distribution of o ' nyong-nyong virus

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• Human Urban Arboviruses Can Infect Wild Animals and Jump to Sylvatic Maintenance Cycles in South America

  2019cited by this paper
• Spondweni Virus in Field-Caught Culex quinquefasciatus Mosquitoes, Haiti, 2016

  2018cited by this paper
• Prediction and prevention of urban arbovirus epidemics: A challenge for the global virology community.

  2018cited by this paper
• Evidence for multiple sylvatic transmission cycles during the 2016-2017 yellow fever virus outbreak, Brazil.

  2018cited by this paper
• Mosquito-Borne Human Viral Diseases: Why Aedes aegypti?

  2018cited by this paper
• Don't reject evidence from CFS therapies

  2018cited by this paper
• Predicting wildlife reservoirs and global vulnerability to zoonotic Flaviviruses

  2018cited by this paper
• Potential of Aedes albopictus as a bridge vector for enzootic pathogens at the urban-forest interface in Brazil

  2018cited by this paper
• Aedes aegypti vector competence studies: A review

  2018cited by this paper
• Recent History of Aedes aegypti: Vector Genomics and Epidemiology Records

  2018cited by this paper
• Yellow fever in Africa and the Americas: a historical and epidemiological perspective

  2018cited by this paper
• Characterization of mitochondrial genome of Haemagogus janthinomys (Diptera: Culicidae)

  2017cited by this paper
• Population genomics of the Asian tiger mosquito, Aedes albopictus: insights into the recent worldwide invasion

  2017cited by this paper
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  2017cited by this paper
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  2017cited by this paper
• Emerging arboviruses: Why today?

  2017cited by this paper
• Potential risk of re-emergence of urban transmission of Yellow Fever virus in Brazil facilitated by competent Aedes populations

  2017cited by this paper
• Yellow fever cases in Asia: primed for an epidemic.

  2016cited by this paper
• Genetic Characterization of Spondweni and Zika Viruses and Susceptibility of Geographically Distinct Strains of Aedes aegypti, Aedes albopictus and Culex quinquefasciatus (Diptera: Culicidae) to Spondweni Virus

  2016cited by this paper
• Aedes aegypti suppression in the Americas: historical perspectives

  2016cited by this paper
• Modelling adult Aedes aegypti and Aedes albopictus survival at different temperatures in laboratory and field settings

  2013cited by this paper
• An update on mosquito cell expressed dengue virus receptor proteins

  2012influential reference
• Mayaro Virus Infection in Amazonia: A Multimodel Inference Approach to Risk Factor Assessment

  2012cited by this paper
• The invaders: phylogeography of dengue and chikungunya viruses Aedes vectors, on the South West islands of the Indian Ocean.

  2011cited by this paper
• Evolutionary forces on Anopheles: what makes a malaria vector?

  2010cited by this paper
• Mosquitoes infected with dengue viruses in Brazil

  2010cited by this paper
• Blood-Feeding Behavior of Aedes albopictus, a Vector of Chikungunya on La Réunion

  2010cited by this paper
• Mosquito Empires: Ecology and War in the Greater Caribbean, 1620-1914

  2010influential reference
• Aedes albopictus, an arbovirus vector: from the darkness to the light.

  2009cited by this paper
• Geographic Distribution and Developmental Sites of Aedes albopictus (Diptera: Culicidae) During a Chikungunya Epidemic Event

  2008cited by this paper
• Destin des maladies infectieuses

  2008cited by this paper
• Aedes albopictus as an epidemic vector of chikungunya virus: another emerging problem?

  2006cited by this paper
• Genome Microevolution of Chikungunya Viruses Causing the Indian Ocean Outbreak

  2006cited by this paper
• In Memoriam 
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  2004cited by this paper
• Invasions by insect vectors of human disease.

  2002cited by this paper
• The mosquito hypothetically considered as the agent of transmission of yellow fever. 1881.

  2001cited by this paper
• Parasitism: The Ecology and Evolution of Intimate Interactions

  2001cited by this paper
• Epidemiology and control of malaria

  1999cited by this paper
• The biology of Aedes albopictus.

  1988cited by this paper
• The biology of Aedes albopictus.

  1988influential reference
• Prevention and control of yellow fever in Africa

  1987cited by this paper
• Les maladies à l'aube de la civilisation occidentale

  1986cited by this paper
• Oral infection of Aedes aegypti with yellow fever virus: geographic variation and genetic considerations.

  1985cited by this paper
• Habitat segregation among African treehole mosquitoes

  1981cited by this paper
• Contributions to the Mosquito Fauna of Southeast Asia. XIV. The Subgenus Stegomyia of Aedes in Southeast Asia I - The Scutellaris Group of Species

  1972cited by this paper
• The elimination of urban yellow fever in the Americas through the eradication of Aedes aegypti.

  1963influential reference
• Aëdes aegypti (L.), the yellow fever mosquito

  1960cited by this paper
• Aëdes Aegypti The Yellow Fever Mosquito: Its Life History, Bionomics and Structure

  1960cited by this paper
• An Account of Dr. Louis-Daniel Beauperthuy

  1908cited by this paper
• The Etiology of Yellow Fever-A Preliminary Note.

  year unknowncited by this paper

• Chromosomal Inversions and Their Potential Impact on the Evolution of Arboviral Vector Aedes aegypti

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• Ecological and physicochemical characteristics of tree holes as mosquito breeding habitats: A systematic review

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• Climate-influenced vector-borne diseases in Africa: a call to empower the next generation of African researchers for sustainable solutions

  2024cites this paper
• Discovery and characterization of chromosomal inversions in the arboviral vector mosquito Aedes aegypti

  2024cites this paper
• Mechanisms of Yellow Fever Transmission: Gleaning the Overlooked Records of Importance and Identifying Problems, Puzzles, Serious Issues, Surprises and Research Questions

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• An Entomological Investigation during a Recent Rift Valley Fever Epizootic/Epidemic Reveals New Aspects of the Vectorial Transmission of the Virus in Madagascar

  2024cites this paper
• Midgut transcriptomic responses to dengue and chikungunya viruses in the vectors Aedes albopictus and Aedes malayensis

  2023cites this paper
• Towards the invasion of wild and rural forested areas in Gabon (Central Africa) by the Asian tiger mosquito Aedes albopictus: Potential risks from the one health perspective

  2023cites this paper
• A fast and inexpensive genotyping system for the simultaneous analysis of human and Aedes albopictus short tandem repeats

  2023cites this paper
• Urban Green Spaces and Vector-Borne Disease Risk in Africa: The Case of an Unclean Forested Park in Libreville (Gabon, Central Africa)

  2023cites this paper
• Plastic pollution and infectious diseases.

  2022cites this paper
• Lethal effect of blue light on Asian tiger mosquito, Aedes albopictus (Diptera: Culicidae)

  2022cites this paper
• Tracking Asian tiger mosquito introductions in the Netherlands using Nextstrain

  2022cites this paper
• Invasion of forested areas in Gabon (Central Africa) by the Asian tiger mosquito and the potential consequences from the One Health perspective

  2022influential citation
• The stochastic world of emerging viruses

  2022cites this paper
• Comptes Rendus Biologies

  2021cites this paper
• Chikungunya, Dengue, Zika, and Other Emerging Mosquito-Borne Viruses

  2021cites this paper
• Inhibition of Aedes aegypti DNA topoisomerase II by etoposide: Impact on survival and morphology of larvae and pupae.

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
• Gene drives gaining speed

  2021cites this paper
• The Global Expansion of Dengue: How Aedes aegypti Mosquitoes Enabled the First Pandemic Arbovirus.

  2020cites this paper
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  2020cites this paper
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  2020cites this paper