Supersensitivity of the denervated rat diaphragm to potassium: a comparison with supersensitivity in other tissues.

Paired strips of isolated diaphragm were compared 5 and 10 days after unilateral denervation. The sensitivity to acetylcholine was increased more than 1000-fold, whereas the sensitivity to potassium was increased 1.5-fold. Concentrations of d -tubocurarine which antagonized both exogenous and endogenously released acetylcholine had no effect on responses to potassium. The responses to potassium therefore seem to reflect a direct effect on the muscles. The relative shifts of the dose-response curves of acetyicholine and potassium in the denervated diaphragm are compared to changes in sensitivity to ions and transmitter substances in supersensitive smooth and cardiac muscle. The suggestion is made that, in addition to receptor spread in skeletal muscle, there are other physiologic mechanisms involved in the supersensitivity to potassium and that similar physiologic changes may occur in smooth muscle and cardiac muscle.

• Publication year

  1971

• Venue

  Journal of Pharmacology and Experimental Therapeutics

• Publication date

  1971-01-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/s0022-3565(25)28771-7PMID 5569632
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nonspecific supersensitivity of the guinea‐pig vas deferens produced by decentralization and reserpine treatment

  1970cited by this paper
• [Influence of denervation of muscle end plates on the localization of acetylcholinesterase and fixation of decamethonium].

  1970cited by this paper
• Nonspecific supersensitivity of the guinea-pig ileum produced by chronic ganglion blockade.

  1968cited by this paper
• The sensitivity of the guinea-pig pacemaker to norepinephrine and calcium after pretreatment with reserpine.

  1968cited by this paper
• Sensitivity changes in the dog heart to norepinephrine, calcium and aminophyline resulting from pretreatment with reserpine.

  1968cited by this paper
• Agonist-antagonist interactions in the normal and supersensitive nictitating membrane of the spinal cat.

  1967cited by this paper
• Time course of the development of supersensitivity to various amines in the nictitating membrane of the pithed cat after denervation or decentralization.

  1967cited by this paper
• Caffeine effects on radiocalcium movement in normal and denervated rat skeletal muscle.

  1967cited by this paper
• A relatively nonspecific supersensitivity in aortic strips resulting from pretreatment with reserpine.

  1966cited by this paper
• Relaxing factor in denervated muscle: a possible explanation for fibrillations.

  1966cited by this paper
• Mechanisms of supersensitivity and subsensitivity to sympathomimetic amines.

  1966cited by this paper
• SUPERSENSITIVITY BY COCAINE TO DEXTROROTATORY ISOMERS OF NOREPINEPHRINE AND EPINEPHRINE.

  1965cited by this paper
• Action of transmitters on the responsiveness of effector cells

  1965cited by this paper
• Acetylcholine and choline acetyltransferase in the diaphragm of the rat

  1964cited by this paper
• The release of acetylcholine from the denervated rat diaphragm

  1964cited by this paper
• Supersensitivity and subsensitivity to sympathomimetic amines.

  1963cited by this paper
• Supersensitivity following "pharmacological denervation".

  1961cited by this paper
• Effects of motor innervation on the chemical sensitivity of skeletal muscle.

  1960cited by this paper
• [Potassium flux of normal and denervated rat diaphragm].

  1960cited by this paper

• Chronic morphine treatment of guinea pigs induces nonspecific sensitivity changes in the nucleus tractus solitarius in vitro.

  1997cites this paper
• Contractures in normal and denervated inferior oblique muscle of the rabbit

  1981cites this paper
• Persistent neuronal blockade with guanethidine in dog mesenteric arteries

  1978cites this paper
• Dual effect of alpha-adrenoceptor antagonists in rat isolated vas deferens.

  1976cites this paper
• DUAL EFFECT OF α‐ADRENOCEPTOR ANTAGONISTS IN RAT ISOLATED VAS DEFERENS

  1976cites this paper
• The role of acetylcholine receptors and acetylcholinesterase activity in the development of denervation supersensitivity.

  1976cites this paper
• A differential effect of chronically administered guanethidine on sympathetic neurotransmission to the dog heart and mesenteric arterial blood vessels.

  1974cites this paper
• Increased response to catecholamines of the cyclic AMP system of rat pineal gland induced by decreased sympathetic activity.

  1974cites this paper
• Comparison of the beta receptor blocking properties of two analogs of dichloroisoproterenol (DCI).

  1973cites this paper
• Postjunctional supersensitivity and subsensitivity of excitable tissues to drugs.

  1973cites this paper
• Morphine-induced changes in the sensitivity of the isolated colon and vas deferens of the rat.

  1972cites this paper