Downregulation of Ezh2 expression by RNA interference induces cell cycle arrest in the G0/G1 phase and apoptosis in U87 human glioma cells.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Oncology Report

• Publication date

  2012-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3892/or.2012.2033PMID 22992977
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MicroRNA-26a regulates tumorigenic properties of EZH2 in human lung carcinoma cells.

  2012cited by this paper
• Down-regulation of the miR-25 and miR-30d contributes to the development of anaplastic thyroid carcinoma targeting the polycomb protein EZH2.

  2012cited by this paper
• Synthetic glycosidated phospholipids induce apoptosis through activation of FADD, caspase-8 and the mitochondrial death pathway

  2011cited by this paper
• Activation of the δ-opioid receptor inhibits serum deprivation-induced apoptosis of human liver cells via the activation of PKC and the mitochondrial pathway

  2011cited by this paper
• Cyclin-dependent Kinase 1 (CDK1)-mediated Phosphorylation of Enhancer of Zeste 2 (Ezh2) Regulates Its Stability*

  2011cited by this paper
• Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells.

  2011cited by this paper
• EZH2 Depletion Blocks the Proliferation of Colon Cancer Cells

  2011cited by this paper
• Mimosine-Induced Apoptosis in C6 Glioma Cells Requires the Release of Mitochondria-Derived Reactive Oxygen Species and p38, JNK Activation

  2011cited by this paper
• Malignant Rhabdoid Tumors Express Stem Cell Factors, Which Relate To the Expression of EZH2 and Id Proteins

  2011cited by this paper
• Enhancer of Zeste Homolog 2 Promotes the Proliferation and Invasion of Epithelial Ovarian Cancer Cells

  2010cited by this paper
• Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2

  2010cited by this paper
• Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression

  2010cited by this paper
• miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis

  2010cited by this paper
• MEK–ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death

  2010cited by this paper
• Apigenin induces caspase-dependent apoptosis in human lung cancer A549 cells through Bax- and Bcl-2-triggered mitochondrial pathway.

  2010cited by this paper
• Decreased expression of EZH2 is associated with upregulation of ER and favorable outcome to tamoxifen in advanced breast cancer

  2010cited by this paper
• Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma.

  2009cited by this paper
• Expression profile of the polycomb group protein enhancer of Zeste homologue 2 and its prognostic relevance in renal cell carcinoma.

  2009cited by this paper
• The importance of surgical resection in malignant glioma

  2009cited by this paper
• The enhancer of zeste homolog 2 gene contributes to cell proliferation and apoptosis resistance in renal cell carcinoma cells

  2008cited by this paper
• Regulation of Pancreatic Tumor Cell Proliferation and Chemoresistance by the Histone Methyltransferase Enhancer of Zeste Homologue 2

  2008cited by this paper
• Epigenetic Control of Hematopoietic Stem Cell Aging The Case of Ezh2

  2007cited by this paper
• Glioma Therapy in Adults

  2006cited by this paper
• Molecular mechanisms of caspase regulation during apoptosis

  2004cited by this paper
• Adult glioma incidence trends in the United States, 1977–2000

  2004cited by this paper
• Mitochondria in cell death: novel targets for neuroprotection and cardioprotection.

  2003cited by this paper
• Cause of death and long-term survival in patients with neuro-epithelial brain tumours: a population-based study.

  2003cited by this paper
• The polycomb group protein EZH2 is involved in progression of prostate cancer

  2002cited by this paper
• The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma

  2001cited by this paper
• BAX-dependent transport of cytochrome c reconstituted in pure liposomes

  2000cited by this paper

• EZH2: The roles in targeted therapy and mechanisms of resistance in breast cancer.

  2024cites this paper
• EZH2-regulated PARP 1 Expression is a Likely Mechanism for the Chemoresistance of Gliomas to Temozolomide.

  2023cites this paper
• The Pivotal Immunoregulatory Functions of Microglia and Macrophages in Glioma Pathogenesis and Therapy

  2022cites this paper
• GSK343, an Inhibitor of Enhancer of Zeste Homolog 2, Reduces Glioblastoma Progression through Inflammatory Process Modulation: Focus on Canonical and Non-Canonical NF-κB/IκBα Pathways

  2022influential citation
• Mitochondria and Their Relationship with Common Genetic Abnormalities in Hematologic Malignancies

  2021cites this paper
• EZH2 as a new therapeutic target in brain tumors: Molecular landscape, therapeutic targeting and future prospects.

  2021cites this paper
• The Pivotal Immunomodulatory and Anti-Inflammatory Effect of Histone-Lysine N-Methyltransferase in the Glioma Microenvironment: Its Biomarker and Therapy Potentials

  2021cites this paper
• Nanocrystallized Oleanolic Acid Better Inhibits Proliferation, Migration and Invasion in Intracranial Glioma via Caspase-3 Pathway

  2020cites this paper
• Ribophorin II is upregulated in myelodysplastic syndromes and prevents apoptosis and cell cycle progression

  2020cites this paper
• Antihistamine Drug Ebastine Inhibits Cancer Growth by Targeting Polycomb Group Protein EZH2

  2020cites this paper
• Critical role of HOX transcript antisense intergenic RNA (HOTAIR) in gliomas

  2020cites this paper
• EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma

  2020cites this paper
• EZH2 is essential for spindle assembly regulation and chromosomal integrity during porcine oocyte meiotic maturation †

  2020cites this paper
• Targeting post-translational histone modifying enzymes in glioblastoma.

  2020cites this paper
• Deregulation of epigenetic mechanisms in cancer

  2018cites this paper
• EZH2 deletion promotes spermatogonial differentiation and apoptosis.

  2017cites this paper
• Effect of EZH 2 Inhibition on Colorectal Cancer Cells : an In Vitro Study

  2017influential citation
• The EZH2 inhibitor GSK343 suppresses cancer stem-like phenotypes and reverses mesenchymal transition in glioma cells

  2017cites this paper
• Functional and therapeutic significance of EZH2 in urological cancers

  2017cites this paper
• EZH2 suppression in glioblastoma shifts microglia toward M1 phenotype in tumor microenvironment

  2017cites this paper
• BCR/ABL increases EZH2 levels which regulates XIAP expression via miRNA-219 in chronic myeloid leukemia cells.

  2016cites this paper
• Modulation of EZH2 Expression by MEK-ERK or PI3K-AKT Signaling in Lung Cancer Is Dictated by Different KRAS Oncogene Mutations.

  2016cites this paper
• Long Noncoding RNAs Regulate Cell Growth, Proliferation, and Apoptosis

  2016cites this paper
• Functional roles of enhancer of zeste homolog 2 in gliomas.

  2016influential citation
• MicroRNA-144 suppresses tumorigenesis and tumor progression of astrocytoma by targeting EZH2.

  2015cites this paper
• Deregulation of histone-modifying enzymes and chromatin structure modifiers contributes to glioma development.

  2015cites this paper
• Alterations in enhancer of zeste homolog 2, matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 expression are associated with ex vivo and in vitro bone metastasis in renal cell carcinoma.

  2015cites this paper
• Retinoic acid-incorporated glycol chitosan nanoparticles inhibit the expression of Ezh2 in U118 and U138 human glioma cells

  2015cites this paper
• Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner

  2014cites this paper
• Inhibition enhancer of zeste homologue 2 promotes senescence and apoptosis induced by doxorubicin in p53 mutant gastric cancer cells

  2014cites this paper
• Epigenetic modification in gliomas: role of the histone methyltransferase EZH2

  2014cites this paper
• PCI-24781 down-regulates EZH2 expression and then promotes glioma apoptosis by suppressing the PIK3K/Akt/mTOR pathway

  2014cites this paper
• Combined aberrant expression of Bmi1 and EZH2 is predictive of poor prognosis in glioma patients.

  2013cites this paper
• Evaluation of Histone 3 Lysine 27 Trimethylation (H3K27me3) and Enhancer of Zest 2 (EZH2) in Pediatric Glial and Glioneuronal Tumors Shows Decreased H3K27me3 in H3F3A K27M Mutant Glioblastomas

  2013cites this paper