Glutamatergic fast-spiking parvalbumin neurons in the lateral hypothalamus: electrophysiological properties to behavior.

Throughout the central nervous system, neurons expressing the calcium-binding protein parvalbumin have been typically classified as GABAergic with fast-spiking characteristics. However, new methods that allow systematic characterization of the cytoarchitectural organization, connectivity, activity patterns, neurotransmitter nature, and function of genetically-distinct cell types have revealed populations of parvalbumin-positive neurons that are glutamatergic. Remarkably, such findings challenge long-standing concepts that fast-spiking neurons are exclusively GABAergic, suggesting conservation of the fast-spiking phenotype across at least two neurotransmitter systems. This review focuses on the recent advancements that have begun to reveal the functional roles of lateral hypothalamic parvalbumin-positive neurons in regulating behaviors essential for survival.

• Publication year

  2020

• Venue

  Physiology and Behavior

• Publication date

  2020-04-11

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.physbeh.2020.112912PMID 32289319PMCID PMC8801204
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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