Activation of the Unfolded Protein Response via Co-expression of the HAC1i Gene Enhances Expression of Recombinant Elastase in Pichia pastoris

No abstract is available for this paper.

• Publication year

  2020

• Venue

  Biotechnology and Bioprocess Engineering

• Publication date

  2020-04-01

• Fields of study

  Biology, Chemistry, Engineering

• Identifiers
  DOI 10.1007/s12257-019-0381-2
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010cited by this paper
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  2008cited by this paper
• Engineering eukaryotic protein factories

  2007cited by this paper
• Open Access Research

  2007influential reference
• Optimized Protein Extraction for Quantitative Proteomics of Yeasts

  2007cited by this paper
• In vitro and in vivo assays to assess the functions of calnexin and calreticulin in ER protein folding and quality control.

  2005cited by this paper
• The Structure of calnexin, an ER chaperone involved in quality control of protein folding.

  2001cited by this paper

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  2025cites this paper
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  2022cites this paper
• [Developments of core technologies in industrial enzymes and green bioprocessing].

  2022cites this paper
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