Point mutations in the beta chain CDR3 can alter the T cell receptor recognition pattern on an MHC class I/peptide complex over a broad interface area.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Molecular Immunology

• Publication date

  1998-07-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0161-5890(98)00056-XPMID 9823758
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pillars Article: The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

  2005cited by this paper
• Mouse T-cell receptor variable gene segment families

  2004cited by this paper
• Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen.

  1998cited by this paper
• Atomic structure of an αβ T cell receptor (TCR) heterodimer in complex with an anti‐TCR Fab fragment derived from a mitogenic antibody

  1998cited by this paper
• Topology of T cell receptor-peptide/class I MHC interaction defined by charge reversal complementation and functional analysis.

  1997cited by this paper
• Major histocompatibility complex recognition by immune receptors: Differences among T cell receptor versus antibody interactions with the VSV8/H‐2Kb complex

  1997cited by this paper
• Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes.

  1996cited by this paper
• The specificity and orientation of a TCR to its peptide-MHC class II ligands.

  1996cited by this paper
• Response of Mycobacterium tuberculosis to Reactive Oxygen and Nitrogen Intermediates

  1996cited by this paper
• Alloreactivity, Antigen Recognition and T‐Cell Selection: Three Diverse T‐Cell Recognition Problems with a Common Solution

  1996cited by this paper
• An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex

  1996cited by this paper
• TCR recognition of the Hb(64-76)/I-Ek determinant: single conservative amino acid changes in the complementarity-determining region 3 dramatically alter antigen fine specificity.

  1996cited by this paper
• Crystal structure of the beta chain of a T cell antigen receptor.

  1995cited by this paper
• Crystal Structure of the Vα Domain of a T Cell Antigen Receptor

  1995cited by this paper
• Diversity of T cell receptors specific for the VSV antigenic peptide (N52-59) bound by the H-2Kb class I molecule.

  1995cited by this paper
• Evidence that the antigen receptors of cytotoxic T lymphocytes interact with a common recognition pattern on the H-2Kb molecule.

  1995cited by this paper
• The three-dimensional structure of peptide-MHC complexes.

  1995cited by this paper
• Crystal structure of the V alpha domain of a T cell antigen receptor.

  1995cited by this paper
• Antigenic peptide binding by class I and class II histocompatibility proteins.

  1994cited by this paper
• Anatomy of the antibody molecule.

  1994cited by this paper
• Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb.

  1994cited by this paper
• T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen

  1993cited by this paper
• How alpha beta T-cell receptors 'see' peptide/MHC complexes.

  1993cited by this paper
• Organization, structure, and function of 95 kb of DNA spanning the murine T-cell receptor C alpha/C delta region.

  1992cited by this paper
• Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition.

  1992cited by this paper
• Mapping the orientation of an antigenic peptide bound in the antigen binding groove of H-2Kb using a monoclonal antibody.

  1992cited by this paper
• Organization, structure, and function of 95 kb of DNA spanning the murine T-cell receptor CαCδ region

  1992cited by this paper
• Vesicular stomatitis virus antigenic octapeptide N52-59 is anchored into the groove of the H-2Kb molecule by the side chains of three amino acids and the main-chain atoms of the amino terminus.

  1992cited by this paper
• Mutational analysis of the fingers domain of human immunodeficiency virus type 1 reverse transcriptase

  1992cited by this paper
• Characterization of thymus-derived lymphocytes expressing Ti alpha-beta CD3 gamma delta epsilon zeta-zeta, Ti alpha-beta CD3 gamma delta epsilon eta-eta or Ti alpha-beta CD3 gamma delta epsilon zeta-zeta/zeta- eta antigen receptor isoforms: analysis by gene transfection

  1990cited by this paper
• Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb molecule

  1990cited by this paper
• Derivation of a T cell hybridoma variant deprived of functional T cell receptor α and β chain transcripts reveals a nonfunctional α‐mRNA of BW5147 origin

  1989cited by this paper
• The outline structure of the T‐cell alpha beta receptor.

  1988cited by this paper
• Evidence that multiple residues on both the alpha-helices of the class I MHC molecule are simultaneously recognized by the T cell receptor.

  1988cited by this paper
• T-cell antigen receptor genes and T-cell recognition

  1988cited by this paper
• SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat

  1988cited by this paper
• Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes.

  1987cited by this paper
• An approach to the study of structure-function relationships of MHC class I molecules: isolation and serologic characterization of H-2Kb somatic cell variants.

  1986cited by this paper
• Secondary, tertiary, and quaternary structure of T-cell-specific immunoglobulin-like polypeptide chains.

  1986cited by this paper
• Turns in peptides and proteins.

  1985cited by this paper
• Somatic recombination in a murine T-cell receptor gene

  1984cited by this paper

• Characterization of amino acid residues of T-cell receptors interacting with HLA-A*02-restricted antigen peptides

  2021cites this paper
• Human cytomegalovirus-specific T-cell receptor engineered for high affinity and soluble expression using mammalian cell display

  2019cites this paper
• Hypergravity exposure during gestation modifies the TCRβ repertoire of newborn mice

  2015cites this paper
• BRAF inhibition is associated with increased clonality in tumor-infiltrating lymphocytes

  2013cites this paper
• ATM Influences the Efficiency of TCRβ Rearrangement, Subsequent TCRβ-Dependent T Cell Development, and Generation of the Pre-Selection TCRβ CDR3 Repertoire

  2013cites this paper
• Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse

  2013cites this paper
• A Conserved Hydrophobic Patch on Vβ Domains Revealed by TCRβ Chain Crystal Structures: Implications for Pre-TCR Dimerization

  2011cites this paper
• A Conserved Hydrophobic Patch on V \(\beta\) Domains Revealed by TCR \(\beta\) Chain Crystal Structures: Implications for Pre-TCR Dimerization

  2011cites this paper
• Many different Vβ CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions

  2009cites this paper
• The MHC-Based Suppression (MBS) Theory: Implications for Transplantation

  2008cites this paper
• T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell.

  2005cites this paper
• Pathologic clonal cytotoxic T-cell responses: nonrandom nature of the T-cell-receptor restriction in large granular lymphocyte leukemia.

  2005cites this paper
• Molecular profile of the T cell receptors of regulatory and effector CD4+ T cells recognizing overlapping determinants on glutamic acid decarboxylase (524-543).

  2004cites this paper
• Modulation of T cell immunity by TCR/pMHC dwell time and activating/inhibitory receptor pairs on the antigen-presenting cell.

  2003cites this paper
• Anti-double-stranded DNA antibodies, nucleosomes, and systemic lupus erythematosus: a time for new paradigms?

  2003cites this paper
• Complementarity-Determining Region 1 Sequence Requirements Drive Limited Vα Usage in Response to Influenza Hemagglutinin 307–319 Peptide1

  2002cites this paper
• Activated TCRs remain marked for internalization after dissociation from pMHC

  2002cites this paper
• Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool.

  2001cites this paper
• Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

  2001cites this paper
• Class I and an Antigenic Peptide Bound to MHC a Possibilities for Interaction between CDR3 Single-Chain Transgenic Mice Reveals New Immunobiological Analysis of TCR

  2001cites this paper
• Immunobiological Analysis of TCR Single-Chain Transgenic Mice Reveals New Possibilities for Interaction between CDR3α and an Antigenic Peptide Bound to MHC Class I1

  2001cites this paper
• Conserved CDR3 Regions in T-Cell Receptor (TCR) CD8+T Cells That Recognize the Tax11-19/HLA-A*0201 Complex in a Subject Infected with Human T-Cell Leukemia Virus Type 1: Relationship of T-Cell Fine Specificity and Major Histocompatibility Complex/Peptide/TCR Crystal Structure

  2001cites this paper
• A simplified procedure for the preparation of MHC/peptide tetramers: chemical biotinylation of an unpaired cysteine engineered at the C-terminus of MHC-I.

  2000cites this paper
• Altered Peptide Ligand-Mediated TCR Antagonism Can Be Modulated by a Change in a Single Amino Acid Residue Within the CDR3β of an MHC Class I-Restricted TCR1

  2000influential citation
• CDR3 in a Single Amino Acid Residue Within the Antagonism Can Be Modulated by a Change Altered Peptide Ligand-Mediated TCR

  2000influential citation
• Variants Multiple HLA-DR Alleles and Peptide Dramatically Improves Response to Both Residues : A Single Conservative Substitution Complementarity-Determining Region 3 Systematic Mutagenesis of TCR

  1999cites this paper
• Systematic mutagenesis of TCR complementarity-determining region 3 residues: a single conservative substitution dramatically improves response to both multiple HLA-DR alleles and peptide variants.

  1999cites this paper
• Conformational and amino acid residue requirements for the saposin C neuritogenic effect.

  1999cites this paper