Noncanonical regulation of phosphatidylserine metabolism by a Sec14-like protein and a lipid kinase

Yaxi Wang,Peihua Yuan,A. Grabon,A. Tripathi,Dongju Lee,Martín Rodríguez,Max Lönnfors,Michal Eisenberg-Bord,Zehua Wang,Sin Man Lam,M. Schuldiner,V. Bankaitis

Published 2020 in Journal of Cell Biology

ABSTRACT

Yeast Psd2-catalyzed decarboxylation of phosphatidylserine to phosphatidylethanolamine is activated in a noncanonical mechanism by the Sec14-like phosphatidylinositol-transfer protein Sfh4 via a specific protein–protein interaction, and by Stt4 PtdIns 4-OH kinase–mediated control of phosphatidylserine accessibility to the enzyme.

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