Exogenous NGF restores endogenous NGF distribution in the brain of the cognitively impaired aged rat.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Brain Research

• Publication date

  2003-03-28

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/S0006-8993(03)02272-8PMID 12650994
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1997cited by this paper
• Carrier mediated delivery of NGF: Alterations in basal forebrain neurons in aged rats revealed using antibodies against low and high affinity NGF receptors

  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994influential reference
• Neurotrophic factor therapy for nervous system degenerative diseases.

  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper
• Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging.

  1992cited by this paper
• Hippocampal nerve growth factor levels are related to spatial learning ability in aged rats.

  1992cited by this paper
• Exogenous nerve growth factor stimulates choline acetyltransferase activity in aging Fischer 344 male rats.

  1991cited by this paper
• Age- and sex-related differences in the nerve growth factor distribution in the rat brain.

  1991cited by this paper
• Involvement of Nerve Growth Factor and Its Receptor in the Regulation of the Cholinergic Function in Aged Rats

  1991influential reference
• Hippocampal NGF levels are not reduced in the aged Fischer 344 rat.

  1991cited by this paper
• Nerve growth factor levels and choline acetyltransferase activity in the brain of aged rats with spatial memory impairments.

  1990cited by this paper
• Age-related loss of nerve growth factor sensitivity in rat basal forebrain neurons.

  1988cited by this paper
• Nerve growth factor treatment after brain injury prevents neuronal death.

  1987cited by this paper
• Decreased level of nerve growth factor (NGF) and its messenger RNA in the aged rat brain.

  1987cited by this paper
• Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

  1987cited by this paper
• Neurotrophic factors.

  1985cited by this paper
• The cholinergic hypothesis of geriatric memory dysfunction.

  1982cited by this paper

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  2007cites this paper
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  2006cites this paper
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