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Pan-genomics of veterinary pathogens and its applications

T. Sousa,A. Jaiswal,R. Hurtado,Stephane Tosta,S. Soares,A. C. Gomide,L. Alcântara,D. Barh,V. Azevedo,S. Tiwari

Published 2020 in Unknown venue

ABSTRACT

Abstract Pan-genome is an approach that contributes to the research of bacterial pathogenesis. From the sequencing data, one can thoroughly study each region of the genome, contributing with unpublished information. Since 2005, with the era of new sequencers, the speed, ease, and reliability of data has been increasing and with them the number of bacterial genomes deposited in public databases. Pan-genome studies can be applied with different goals, such as taxonomy, reverse vaccinology, gene variation, and pathogenesis, among others. This chapter is focused on the pan-genomics studies carried out on pathogenic bacteria that cause veterinary diseases, including the ones responsible for zoonotic diseases. These studies showed a great diversity at the genome level which may reflect the associations of genetic groups that could be involved with the capacity to infect and adaptations in different host. From the genetic repertoire studies, the key points (genes) supposedly involved in the spread of a disease, bacterial resistance, infection, adhesion, can be detected, leading to effective solutions against the disease being studied.

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