Neuronal hypertrophy dampens neuronal intrinsic excitability and stress responsiveness during chronic stress

The hypothalamic‐pituitary‐adrenal (HPA) axis habituates to repeated stress exposure. We studied hypothalamic corticotropin‐releasing hormone (CRH) neurons that form the apex of the HPA axis in a mouse model of stress habituation using repeated restraint. The intrinsic excitability of CRH neurons decreased after repeated stress in a time course that coincided with the development of HPA axis habituation. This intrinsic excitability plasticity co‐developed with an expansion of surface membrane area, which increased a passive electric load and dampened membrane depolarization in response to the influx of positive charge. We report a novel structure–function relationship for intrinsic excitability plasticity as a neural correlate for HPA axis habituation.

• Publication year

  2020

• Venue

  Journal of Physiology

• Publication date

  2020-04-29

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1113/JP279666PMID 32347541
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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