Morbidity of Cushing's Syndrome and Impact of Treatment.

Cortisol excess in Cushing's syndrome is associated with metabolic, cardiovascular, and cognitive alterations, only partially reversible after resolution of hypercortisolism. Elevated cardiovascular risk may persist after eucortisolism has been achieved. Fractures and low bone mineral density are also described in Cushing's syndrome in remission. Hypercortisolism may induce irreversible structural and functional changes in the brain, leading to neuropsychiatric disorders in the active phase of the disease, which persist. Sustained deterioration of the cardiovascular system, bone remodeling, and cognitive function along with neuropsychological impairment are associated with high morbidity and poor quality of life before and after remission.

• Publication year

  2018

• Venue

  Endocrinology and metabolism clinics of North America (Print)

• Publication date

  2018-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.ecl.2018.01.001PMID 29754633
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cushing’s Syndrome

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  2017cited by this paper
• Decreased prefrontal functional brain response during memory testing in women with Cushing's syndrome in remission.

  2017cited by this paper
• MANAGEMENT OF ENDOCRINE DISEASE: Quality of life tools for the management of pituitary disease.

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  2016cited by this paper
• Using subscales when scoring the Cushing's quality of life questionnaire.

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• Altered neural processing of emotional faces in remitted Cushing's disease.

  2015cited by this paper
• Metabolic comorbidities in Cushing's syndrome.

  2015cited by this paper
• Bone density and microarchitecture in endogenous hypercortisolism

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• Mental Fatigue and Executive Dysfunction in Patients with Cushing's Syndrome in Remission

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• Neuropsychiatric disorders in Cushing's syndrome

  2015cited by this paper
• The hypertension of Cushing's syndrome: controversies in the pathophysiology and focus on cardiovascular complications

  2015cited by this paper
• The Treatment of Cushing's Disease.

  2015cited by this paper
• MECHANISMS IN ENDOCRINOLOGY: Cushing's syndrome causes irreversible effects on the human brain: a systematic review of structural and functional magnetic resonance imaging studies.

  2015cited by this paper
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  2015cited by this paper
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  2014cited by this paper
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  2014cited by this paper
• Impaired decision‐making and selective cortical frontal thinning in Cushing's syndrome

  2014cited by this paper
• Cardiac Structure and Function in Cushing's Syndrome: A Cardiac Magnetic Resonance Imaging Study

  2014cited by this paper
• Widespread reductions of white matter integrity in patients with long-term remission of Cushing's disease

  2014cited by this paper
• A direct comparison of quality of life in obese and Cushing's syndrome patients.

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• Decreased Autonomic Modulation of Heart Rate and Altered Cardiac Sympathovagal Balance in Patients with Cushing's Syndrome: Role of Endogenous Hypercortisolism

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• Hippocampal dysfunction in cured Cushing's syndrome patients, detected by 1H‐MR‐spectroscopy

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• Hypercoagulability in Cushing's syndrome: prevalence, pathogenesis and treatment

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• Hypercortisolism is associated with increased coronary arterial atherosclerosis: analysis of noninvasive coronary angiography using multidetector computerized tomography.

  2013cited by this paper
• Coronary artery disease detected by multislice computed tomography in patients after long-term cure of Cushing's syndrome.

  2013cited by this paper
• Body composition and cardiovascular risk markers after remission of Cushing's disease: a prospective study using whole-body MRI.

  2012cited by this paper
• Verbal and visual memory performance and hippocampal volumes, measured by 3-Tesla magnetic resonance imaging, in patients with Cushing's syndrome.

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• Clinical relevance of cardiac structure and function abnormalities in patients with Cushing’s syndrome before and after cure

  2012cited by this paper
• Clinical consequences of Cushing’s syndrome

  2012cited by this paper
• Impaired quality of life in patients in long-term remission of Cushing's syndrome of both adrenal and pituitary origin: a remaining effect of long-standing hypercortisolism?

  2012cited by this paper
• Psychometric performance of the CushingQoL questionnaire in conditions of real clinical practice.

  2012cited by this paper
• Long-term cognitive impairments and attentional deficits in patients with Cushing's disease and cortisol-producing adrenal adenoma in remission.

  2012cited by this paper
• Increased myocardial fibrosis and left ventricular dysfunction in Cushing's syndrome.

  2012cited by this paper
• The European Registry on Cushing's syndrome: 2-year experience. Baseline demographic and clinical characteristics.

  2011cited by this paper
• Incidence of venous thromboembolism in patients with Cushing's syndrome: a multicenter cohort study.

  2011cited by this paper
• Adipokines and Cardiovascular Risk in Cushing’s Syndrome

  2011cited by this paper
• Negative illness perceptions are associated with impaired quality of life in patients after long-term remission of Cushing's syndrome.

  2011cited by this paper
• Coping strategies in patients after treatment for functioning or nonfunctioning pituitary adenomas.

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• Subtle cognitive impairments in patients with long-term cure of Cushing's disease.

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• Persistent body fat mass and inflammatory marker increases after long-term cure of Cushing's syndrome.

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  2009cited by this paper
• Waiting for change: symptom resolution after adrenalectomy for Cushing's syndrome.

  2008cited by this paper
• Evaluation of health-related quality of life in patients with Cushing's syndrome with a new questionnaire.

  2008cited by this paper
• [Cushing's syndrome].

  2008cited by this paper
• Circadian Blood Pressure Profile in Patients with Active Cushing's Disease and after Long-term Cure

  2007cited by this paper
• Long-term impaired quality of life in Cushing's syndrome despite initial improvement after surgical remission.

  2006cited by this paper
• Cushing's Syndrome and Bone

  2005cited by this paper
• Quality of life in patients after long-term biochemical cure of Cushing's disease.

  2005cited by this paper
• Left ventricular structural and functional characteristics in Cushing's syndrome.

  2003cited by this paper
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  2003cited by this paper
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  2001cited by this paper
• Cognitive decline in patients with Cushing's syndrome

  2000cited by this paper
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  1999cited by this paper
• Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure.

  1999cited by this paper
• Clinical Correlates of Major Depression in Cushing’s Disease

  1998cited by this paper
• Psychological aspects of endocrine disease

  1998cited by this paper
• Estimation of body fat and lean tissue distribution by dual energy X-ray absorptiometry and abdominal body fat evaluation by computed tomography in Cushing's disease.

  1995cited by this paper
• Cushing's syndrome from the patient's perspective.

  1994cited by this paper
• Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome.

  1992cited by this paper
• Normal bone mineral density following cure of Cushing's syndrome

  1992cited by this paper
• Refractoriness to thyroid hormone in hypothyroid patients.

  1956cited by this paper

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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
• Autonomous hypercortisolism: definition and clinical implications.

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  2018cites this paper
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