pMHC affinity controls duration of CD8+ T cell–DC interactions and imprints timing of effector differentiation versus expansion

A. Ozga,F. Moalli,J. Abe,J. Swoger,J. Sharpe,D. Zehn,M. Kreutzfeldt,D. Merkler,Jorge Ripoll,J. Stein

Published 2016 in Journal of Experimental Medicine

ABSTRACT

Ozga and colleagues use intravital two-photon microscopy and quantitative whole-organ imaging to reveal the dynamics of early affinity-driven CD8+ T cell activation.

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