Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Developmental Cell

• Publication date

  2014-01-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.devcel.2013.11.023PMID 24412576PMCID PMC3970081
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Activation of conventional kinesin motors in clusters by Shaw voltage-gated K+ channels

  2013cited by this paper
• Coupling Mechanical Forces to Electrical Signaling

  2013cited by this paper
• Astrocytes differentially respond to inflammatory autoimmune insults and imbalances of neural activity

  2013cited by this paper
• Sodium channels, the electrogenisome and the electrogenistat: lessons and questions from the clinic

  2012cited by this paper
• Voltage‐gated sodium channels at 60: structure, function and pathophysiology

  2012cited by this paper
• K+ channel alterations in the progression of experimental autoimmune encephalomyelitis.

  2012cited by this paper
• Assembly and maintenance of nodes of ranvier rely on distinct sources of proteins and targeting mechanisms.

  2012cited by this paper
• A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly.

  2012cited by this paper
• Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

  2012cited by this paper
• THE CRYSTAL STRUCTURE OF A VOLTAGE-GATED SODIUM CHANNEL

  2011cited by this paper
• Alternative Splicing Regulates Kv3.1 Polarized Targeting to Adjust Maximal Spiking Frequency*

  2011cited by this paper
• A Critical Role for Neurofascin in Regulating Action Potential Initiation through Maintenance of the Axon Initial Segment

  2011cited by this paper
• unc-33/CRMP and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting

  2011cited by this paper
• Clustering and Activity Tuning of Kv1 Channels in Myelinated Hippocampal Axons*

  2011cited by this paper
• Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.

  2010cited by this paper
• A glial signal consisting of gliomedin and NrCAM clusters axonal Na+ channels during the formation of nodes of Ranvier.

  2010cited by this paper
• Dynamics of Kv1 Channel Transport in Axons

  2010cited by this paper
• SYMPOSIUM REVIEW: Going native: voltage‐gated potassium channels controlling neuronal excitability

  2010cited by this paper
• Kinesin I Transports Tetramerized Kv3 Channels through the Axon Initial Segment via Direct Binding

  2010cited by this paper
• Walking the walk: how kinesin and dynein coordinate their steps.

  2009cited by this paper
• Electrogenic Tuning of the Axon Initial Segment

  2009influential reference
• Distinct contributions of Nav1.6 and Nav1.2 in action potential initiation and backpropagation

  2009cited by this paper
• Membrane domains based on ankyrin and spectrin associated with cell-cell interactions.

  2009cited by this paper
• Role of the terminal domains in sodium channel localization

  2009cited by this paper
• AnkyrinG is required to maintain axo-dendritic polarity in vivo

  2009cited by this paper
• A selective filter for cytoplasmic transport at the axon initial segment.

  2009cited by this paper
• Localization and targeting of voltage-dependent ion channels in mammalian central neurons.

  2008cited by this paper
• Nodes of Ranvier and axon initial segments are ankyrin G–dependent domains that assemble by distinct mechanisms

  2007cited by this paper
• The Axon–Dendrite Targeting of Kv3 (Shaw) Channels Is Determined by a Targeting Motif That Associates with the T1 Domain and Ankyrin G

  2007cited by this paper
• Neurofascin assembles a specialized extracellular matrix at the axon initial segment

  2007cited by this paper
• A Common Ankyrin-G-Based Mechanism Retains KCNQ and NaV Channels at Electrically Active Domains of the Axon

  2006cited by this paper
• The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting.

  2006cited by this paper
• Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent

  2006cited by this paper
• Neurofascins are required to establish axonal domains for saltatory conduction.

  2005cited by this paper
• A Targeting Motif Involved in Sodium Channel Clustering at the Axonal Initial Segment

  2003cited by this paper
• Functional Specialization of the Axon Initial Segment by Isoform-Specific Sodium Channel Targeting

  2003cited by this paper
• Kv3.1b Is a Novel Component of CNS Nodes

  2003cited by this paper
• A Conserved Domain in Axonal Targeting of Kv1 (Shaker) Voltage-Gated Potassium Channels

  2003cited by this paper
• Dissociation of spectrin-ankyrin complex as a basis for loss of Na-K-ATPase polarity after ischemia.

  2003cited by this paper
• The molecular motor toolbox for intracellular transport.

  2003cited by this paper
• Polarized domains of myelinated axons.

  2003cited by this paper
• Kinesin Moves by an Asymmetric Hand-Over-Hand Mechanism

  2003cited by this paper
• CK2 constitutively associates with and phosphorylates chicken erythroid ankyrin and regulates its ability to bind to spectrin

  2002cited by this paper
• Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites

  2002cited by this paper
• Kinesin molecular motors: Transport pathways, receptors, and human disease

  2001cited by this paper
• Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues.

  2001cited by this paper
• Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments

  2001influential reference
• Voltage-Gated Ion Channels Review and Electrical Excitability

  1998cited by this paper
• AnkyrinG Is Required for Clustering of Voltage-gated Na Channels at Axon Initial Segments and for Normal Action Potential Firing

  1998cited by this paper
• Action potential initiation and backpropagation in neurons of the mammalian CNS.

  1997influential reference
• The ANK Repeats of Erythrocyte Ankyrin Form Two Distinct but Cooperative Binding Sites for the Erythrocyte Anion Exchanger (*)

  1995cited by this paper
• Mechanism for Binding Site Diversity on Ankyrin:

  1995cited by this paper
• Heteromultimeric K+ channels in terminal and juxtaparanodal regions of neurons

  1993cited by this paper
• Ion channel organization of the myelinated fiber.

  1990cited by this paper
• Phosphorylation of ankyrin down‐regulates its cooperative interaction with spectrin and protein 3

  1988cited by this paper
• The establishment of polarity by hippocampal neurons in culture

  1988cited by this paper
• Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo

  1952cited by this paper
• Materials and Methods Som Text Figs. S1 to S3 References and Notes Kinesin Moves by an Asymmetric Hand-over-hand Mechanism

  year unknowncited by this paper

• Ankyrin-G and Its Binding Partners in Neurons: Orchestrating the Molecular Structure of the Axon Initial Segment

  2025cites this paper
• Blocking axon-glial mechanotransduction to prevent concussive brain injury

  2025cites this paper
• Structural electrobiology: architecture of the bioelectric code.

  2025cites this paper
• Sculpting excitable membranes: voltage-gated ion channel delivery and distribution

  2025cites this paper
• Real-time imaging of axonal membrane protein life cycles

  2024cites this paper
• The phenotypic and genotypic spectrum of individuals with mono‐ or biallelic ANK3 variants

  2024cites this paper
• Motor learning changes the axon initial segment of the spinal motoneuron

  2024influential citation
• Kif15 deficiency contributes to depression-like behavior in mice

  2023cites this paper
• Correlative Increasing Expressions of KIF5b and Nav1.7 in DRG Neurons of Rats under Neuropathic Pain Conditions.

  2023cites this paper
• A cytoskeleton-membrane interaction conserved in fast-spiking neurons controls movement, emotion, and memory

  2023cites this paper
• Microtubule plus-end tracking proteins: novel modulators of cardiac sodium channels and arrhythmogenesis

  2023cites this paper
• Roles and mechanisms of ankyrin-G in neuropsychiatric disorders

  2022cites this paper
• Immediate induction of varicosities by transverse compression but not uniaxial stretch in axon mechanosensation

  2022cites this paper
• The fates of internalized NaV1.7 channels in sensory neurons: Retrograde cotransport with other ion channels, axon-specific recycling, and degradation

  2022cites this paper
• Epilepsy gene prickle ensures neuropil glial ensheathment through regulating cell adhesion molecules

  2022cites this paper
• The Mechanical Microenvironment Regulates Axon Diameters Visualized by Cryo-Electron Tomography

  2022cites this paper
• Axon-Targeting Motifs: Mechanisms and Applications of Enhancing Axonal Localisation of Transmembrane Proteins

  2022cites this paper
• Heterophilic and homophilic cadherin interactions in intestinal intermicrovillar links are species dependent

  2021cites this paper
• Completion of neuronal remodeling prompts myelination along developing motor axon branches

  2021cites this paper
• Mammalian Neuronal mRNA Transport Complexes: The Few Knowns and the Many Unknowns

  2021cites this paper
• Specific depletion of the motor protein KIF5B leads to deficits in dendritic transport, synaptic plasticity and memory

  2020cites this paper
• The clustering of voltage-gated sodium channels in various excitable membranes

  2020cites this paper
• Morphological neurite changes induced by porcupine inhibition are rescued by Wnt ligands

  2020cites this paper
• Assembly and Function of the Juxtaparanodal Kv1 Complex in Health and Disease

  2020cites this paper
• Neurofascin and Kv7.3 are delivered to somatic and axon terminal surface membranes en route to the axon initial segment

  2020cites this paper
• Species-Dependent Heterophilic and Homophilic Cadherin Interactions in Intestinal Intermicrovillar Links

  2020cites this paper
• Postnatal Role of the Cytoskeleton in Adult Epileptogenesis

  2020cites this paper
• Structural and Functional Refinement of the Axon Initial Segment in Avian Cochlear Nucleus during Development

  2020cites this paper
• Independent anterograde transport and retrograde cotransport of domain components of myelinated axons

  2020cites this paper
• Cargo hold and delivery: Ankyrins, spectrins, and their functional patterning of neurons

  2020cites this paper
• Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain

  2020cites this paper
• Copper chelation and autoimmunity differentially impact myelin in the hippocampal-prefrontal circuit.

  2019cites this paper
• TBC1D24 regulates axonal outgrowth and membrane trafficking at the growth cone in rodent and human neurons

  2019cites this paper
• Cilia function is associated with axon initial segment morphology.

  2019cites this paper
• The Spatiotemporal Construction of the Axon Initial Segment via KIF3/KAP3/TRIM46 Transport under MARK2 Signaling.

  2019cites this paper
• An alternative mechanism of early nodal clustering and myelination onset in GABAergic neurons of the central nervous system

  2019influential citation
• Identification of an adhesive interface for the non-clustered δ1 protocadherin-1 involved in respiratory diseases

  2019cites this paper
• Building sensory axons: Delivery and distribution of NaV1.7 channels and effects of inflammatory mediators

  2019cites this paper
• Region-specific interneuron demyelination and heightened anxiety-like behavior induced by adolescent binge alcohol treatment

  2019cites this paper
• Trafficking mechanisms underlying Nav channel subcellular localization in neurons

  2019cites this paper
• The clustering of voltage‐gated sodium channels in various excitable membranes

  2019cites this paper
• Melatonin receptors: molecular pharmacology and signalling in the context of system bias

  2018cites this paper
• hnRNP R and its main interactor, the noncoding RNA 7SK, coregulate the axonal transcriptome of motoneurons

  2018cites this paper
• Ankyrins: Roles in synaptic biology and pathology

  2018cites this paper
• An Adhesive Interface for the Non-Clustered δ1 Protocadherin-1 Involved in Respiratory Diseases

  2018cites this paper
• Balanced Activity between Kv3 and Nav Channels Determines Fast-Spiking in Mammalian Central Neurons

  2018cites this paper
• Sodium Channel Trafficking.

  2018cites this paper
• The Axon Initial Segment: An Updated Viewpoint

  2018cites this paper
• Multiple myosin motors interact with sodium/potassium-ATPase alpha 1 subunits

  2018cites this paper
• Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner.

  2018cites this paper
• Nonmuscle myosin II isoforms interact with sodium channel alpha subunits

  2018cites this paper
• Hippocampal to basal forebrain transport of Mn2+ is impaired by deletion of KLC1, a subunit of the conventional kinesin microtubule‐based motor

  2017cites this paper
• δ-Protocadherin Function: From Molecular Adhesion Properties to Brain Circuitry

  2017cites this paper
• Polarity of varicosity initiation in central neuron mechanosensation

  2017influential citation
• Lithium reverses behavioral and axonal transport-related changes associated with ANK3 bipolar disorder gene disruption.

  2017cites this paper
• Early and Late Loss of the Cytoskeletal Scaffolding Protein, Ankyrin G Reveals Its Role in Maturation and Maintenance of Nodes of Ranvier in Myelinated Axons

  2017cites this paper
• JCB_201606065 2179..2200

  2017influential citation
• Adaptor Protein 2 (AP-2) complex is essential for functional axogenesis in hippocampal neurons

  2017cites this paper
• The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels

  2017cites this paper
• The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional Implications and Regulatory Mechanisms

  2017cites this paper
• Etude du rôle des oligodendrocytes dans les mécanismes de formation des noeuds de Ranvier

  2016cites this paper
• Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons

  2016cites this paper
• Fibroblast Growth Factor Homologous Factors

  2016cites this paper
• An Adaptable Spectrin/Ankyrin-Based Mechanism for Long-Range Organization of Plasma Membranes in Vertebrate Tissues.

  2016cites this paper
• Microtubule Dynamics in Neuronal Morphogenesis

  2016cites this paper
• Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in Zebrafish

  2016cites this paper
• Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation

  2016cites this paper
• The Axon Initial Segment, 50Years Later: A Nexus for Neuronal Organization and Function.

  2016influential citation
• Ankyrin G Expression Regulates Apical Delivery of the Epithelial Sodium Channel (ENaC)*

  2016cites this paper
• Cell adhesion molecule L1 contributes to neuronal excitability regulating the function of voltage-gated Na+ channels

  2016cites this paper
• Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy

  2016cites this paper
• Ankyrin G Membrane Partners Drive the Establishment and Maintenance of the Axon Initial Segment

  2016cites this paper
• CELL ADHESION MOLECULE L 1 CONTRIBUTES TO NEURONAL EXCITABILITY REGULATING THE FUNCTION OF VOLTAGE-GATED SODIUM CHANNELS

  2016cites this paper
• Differential Nav and KCNQ2/3 channel binding to Ankyrin-G 1 An Ankyrin-G N-terminal gate and casein kinase 2 dually regulate binding of voltage-gated sodium and KCNQ2/3 potassium channels

  2015cites this paper
• Mechanisms of sodium channel clustering and its influence on axonal impulse conduction

  2015cites this paper
• An Ankyrin-G N-terminal Gate and Protein Kinase CK2 Dually Regulate Binding of Voltage-gated Sodium and KCNQ2/3 Potassium Channels*

  2015cites this paper
• Redistribution of Kv1 and Kv7 enhances neuronal excitability during structural axon initial segment plasticity

  2015cites this paper
• Acceleration of conduction velocity linked to clustering of nodal components precedes myelination

  2015cites this paper
• The ins and outs of polarized axonal domains.

  2015cites this paper
• Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3

  2015cites this paper
• Preferential Targeting of Nav1.6 Voltage-Gated Na+ Channels to the Axon Initial Segment during Development

  2015cites this paper
• Subcellular transcriptome alterations in a cell culture model of spinal muscular atrophy point to widespread defects in axonal growth and presynaptic differentiation

  2014cites this paper
• Physiological and Pathological Functions of Mechanosensitive Ion Channels

  2014cites this paper
• Role of the Axonal Initial Segment in Psychiatric Disorders: Function, Dysfunction, and Intervention

  2014cites this paper
• presynaptic differentiation muscular atrophy point to widespread defects in axonal growth and Subcellular transcriptome alterations in a cell culture model of spinal Material Supplemental

  2014cites this paper
• The node of Ranvier in CNS pathology

  2014cites this paper
• Dynamitin affects cell-surface expression of voltage-gated sodium channel Nav1.5.

  2014cites this paper
• The Role of Potassium Ion and Water Channels in an Animal Model of Multiple Sclerosis

  2014cites this paper
• A HIERARCHY OF ANKYRIN/SPECTRIN COMPLEXES CLUSTERS SODIUM CHANNELS AT NODES OF RANVIER

  2014cites this paper
• prickle modulates microtubule polarity and axonal transport to ameliorate seizures in flies

  2014influential citation
• CK2 accumulation at the axon initial segment depends on sodium channel Nav1

  2014cites this paper
• Ankyrin G membrane partners drive the establishment and maintenance of the axon initial segment

  year unknowninfluential citation
• Effects of chronic lithium treatment on neuronal excitability and GABAergic transmission in an Ank3 mutant mouse model

  year unknowncites this paper