Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice

BackgroundSchistosomiasis is caused by helminth parasites of the genus Schistosoma. Berberine chloride (BER), an isoquinoline alkaloid, has been used in vivo for its antiparasitic, antioxidant and hepatoprotective properties. In this study, the protective effect of BER and praziquantel has been compared for the extent of schistosomiasis-induced oxidative stress in hepatic tissue of mice.ResultsS. mansoni was able to induce inflammation and injury to the liver, evidenced (i) by an increase in inflammatory cellular infiltrations, dilated sinusoids and vacuolated hepatocytes, (ii) by decreased levels of alanine and aspartate aminotransferases and increased levels of alkaline phosphatase, γ-glutamyl transferase in the liver homogenate, (iii) by increased production of nitric oxide and thiobarbituric acid reactive substances, and (iv) by lowered glutathione levels and decreased activities of catalase and superoxide dismutase, respectively. All these infection-induced parameters were significantly altered during BER treatment. In particular, berberine counteracted the S. mansoni-induced loss of glutathione and the activities of catalase and superoxide dismutase.ConclusionBased on these results, it is concluded that berberine could ameliorate pre-existing liver damage and oxidative stress conditions due to schistosomiasis.

• Publication year

  2014

• Venue

  Biological Research

• Publication date

  2014-04-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1186/0717-6287-47-8PMID 25027521PMCID 4103990
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hepatoprotection of Berberine Against Hydrogen Peroxide‐induced Apoptosis by Upregulation of Sirtuin 1

  2013cited by this paper
• Levels of oxidative stress markers: correlation with hepatic function and worm burden patients with schistosomiasis

  2012cited by this paper
• Phytochemical Evaluation and Quantification of Primary Metabolites of Alangium Salviifolium

  2010cited by this paper
• Elimination of Schistosoma mansoni Adult Worms by Rhesus Macaques: Basis for a Therapeutic Vaccine?

  2008cited by this paper
• The effect of antioxidant properties of aqueous garlic extract and Nigella sativa as anti-schistosomiasis agents in mice.

  2008cited by this paper
• Oxidative and nitrative stress in Opisthorchis viverrini-infected hamsters: an indirect effect after praziquantel treatment.

  2008cited by this paper
• Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis

  2008cited by this paper
• Outcomes of Schistosoma mansoni infection in outbred albino mice exposed to Larvin contaminant

  2008cited by this paper
• PROTECTION BY AND ANTI‐OXIDANT MECHANISM OF BERBERINE AGAINST RAT LIVER FIBROSIS INDUCED BY MULTIPLE HEPATOTOXIC FACTORS

  2008cited by this paper
• Effects of tomato extract on oxidative stress induced toxicity in different organs of rats.

  2008cited by this paper
• The central role of glutathione in the pathophysiology of human diseases

  2007cited by this paper
• Developmental toxicity evaluation of berberine in rats and mice.

  2006cited by this paper
• Pharmacokinetics of Berberine and Its Main Metabolites in Conventional and Pseudo Germ-Free Rats Determined by Liquid Chromatography/Ion Trap Mass Spectrometry

  2006cited by this paper
• Directing thrombin.

  2005cited by this paper
• Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats.

  2005cited by this paper
• Measurement of nitric oxide by reconversion of nitrate/nitrite to NO.

  2004cited by this paper
• Protective effect of L-cysteine and glutathione on the modulated suckling rat brain Na+, K+, -ATPase and Mg2+ -ATPase activities induced by the in vitro galactosaemia.

  2004cited by this paper
• Antiradical and antioxidant activities of alkaloids isolated from Mahonia aquifolium. Structural aspects.

  2004cited by this paper
• Induction of interleukin‐12 production in mouse macrophages by berberine, a benzodioxoloquinolizine alkaloid, deviates CD4+ T cells from a Th2 to a Th1 response

  2003cited by this paper
• Biochemical changes after subchronic and chronic interaction of Schistosoma mansoni infection in Swiss albino mice with two specific compounds.

  2003cited by this paper
• A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species.

  2002cited by this paper
• Inhibitory effect of berberine on tert-butyl hydroperoxide-induced oxidative damage in rat liver

  2002cited by this paper
• Experimental models of Schistosoma mansoni infection.

  2002cited by this paper
• IL-4 Plays a Crucial Role in Regulating Oxidative Damage in the Liver During Schistosomiasis1

  2001cited by this paper
• Hyperlipidemia promotes thrombosis after injury to atherosclerotic vessels in apolipoprotein E-deficient mice.

  2000cited by this paper
• Medicinal plants: a re-emerging health aid

  1999cited by this paper
• Regulated production of type I collagen and inflammatory cytokines by peripheral blood fibrocytes.

  1998cited by this paper
• Prospects for Plant Anthelmintics in Tropical Veterinary Medicine

  1997cited by this paper
• Berberine: Therapeutic Potential of an Alkaloid Found in Several Medicinal Plants

  1997influential reference
• Histological grading and staging of chronic hepatitis.

  1995cited by this paper
• Histological grading and staging of chronic hepatitis.

  1995cited by this paper
• Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.

  1979cited by this paper
• [Serum bilirubin determination in newborn infants. A new micromethod for the determination of serum of plasma bilirubin in newborn infants].

  1975cited by this paper
• A Kinetic Photometric Method for Serum γ-Glutamyl Transpeptidase

  1969cited by this paper
• A kinetic photometric method for serum gamma-glutamyl transpeptidase.

  1969cited by this paper
• A quantitative post-mortem study of Schistosomiasis mansoni in man.

  1968cited by this paper
• New approach to the screening of drugs in experimental schistosomiasis mansoni in mice.

  1962cited by this paper
• Tissue sulfhydryl groups.

  1959cited by this paper
• A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.

  1957cited by this paper
• An efficient method for exposure of mice to cercariae of Schistosoma mansoni.

  1952cited by this paper

• Formulation and characterization of BBR loaded niosomes using saponin as a nonionic biosurfactant investigating synergistic effects to enhance antibacterial activity

  2025cites this paper
• Chronic S. mansoni infection critically regulates PbA infection-associated severity and pathological events in a mouse model

  2025cites this paper
• Treating Hymenolepiasis with Pumpkin Seeds: Effect on Ileum Histology and Dwarf Tapeworm Morphology

  2025cites this paper
• Sanguinarine: an alkaloid with promising in vitro and in vivo antiparasitic activity against different developmental stages of Schistosoma mansoni and in silico pharmacokinetic properties (ADMET)

  2024cites this paper
• In vitro killing effect of berberine and niclosamide on ocular Demodex folliculorum.

  2024cites this paper
• Melittin ameliorates schistosomiasis-induced liver fibrosis by suppressing signal transducer and activator of transcription 3 and nuclear factor kappa B

  2024cites this paper
• In Vitro Inhibitory Effect of Berberine Against Rotavirus

  2024cites this paper
• Research progress in the treatment of schistosomiasis with traditional Chinese medicine.

  2024cites this paper
• Response to treatment of murine schistosomiasis with recombinant IL-22 under different circadian timing

  2023cites this paper
• Immunomodulating and Anti-parasitary Mechanisms of Plant Products in the Treatment of Schistosomiasis

  2023cites this paper
• Therapeutic Efficacy of Albendazole and Berberine Loaded on Bovine Serum Albumin Nanoparticles on Intestinal and Muscular Phases of Experimental Trichinellosis.

  2023cites this paper
• Protein undernutrition reduces the efficacy of praziquantel in a murine model of Schistosoma mansoni infection

  2022cites this paper
• Antibacterial activity of a berberine nanoformulation

  2022cites this paper
• Effect of berberine on copper and zinc levels in chickens infected with Eimeria tenella.

  2022cites this paper
• Pathological and immunological evaluation of different regimens of praziquantel treatment in a mouse model of Schistosoma mansoni infection

  2022cites this paper
• Schistosomicidal and hepatoprotective activity of gamma-aminobutyric acid (GABA) alone or combined with praziquantel against Schistosoma mansoni infection in murine model.

  2022cites this paper
• Microwave- and Ultrasound-Assisted Extraction of Cucurbita pepo Seeds: A Comparison Study of Antioxidant Activity, Phenolic Profile, and In-Vitro Cells Effects

  2022cites this paper
• Hepatosplenic Protective Actions of Spirulina platensis and Matcha Green Tea Against Schistosoma mansoni Infection in Mice via Antioxidative and Anti-inflammatory Mechanisms

  2021influential citation
• Antiparasitic Asian medicinal plants in the Clade Eudicots

  2021cites this paper
• Complexation-induced tuning of optical properties of a medically important alkaloid, berberine in the presence of charged cyclodextrin

  2021cites this paper
• Evaluation of Berberine as an Adjunct to TB Treatment

  2021cites this paper
• Botanical candidates from Saudi Arabian flora as potential therapeutics for Plasmodium infection

  2020cites this paper
• Histopathological and biochemical studies on immunocompetent and immunocompromised Hymenolepis nana infected mice treated with Commiphora molmol (Mirazid)

  2020cites this paper
• Phytochemical Screening and Antiprotozoal Effects of the Methanolic Berberis Vulgaris and Acetonic Rhus Coriaria Extracts

  2020cites this paper
• Effects of Dodonaea viscosa Ethanolic Extract on Experimental Schistosomiasis in Mice

  2020cites this paper
• The pharmacological activity of berberine, a review for liver protection.

  2020cites this paper
• Cellular delivery and enhanced anticancer activity of berberine complexed with a cationic derivative of γ-cyclodextrin.

  2019cites this paper
• Probiotics and yogurt modulate oxidative stress and fibrosis in livers of Schistosoma mansoni-infected mice

  2019cites this paper
• Anthelmintic Potential of Cucurbita pepo Seeds on Hymenolepis nana

  2019cites this paper
• Effects of supramolecular complexation of praziquantel with disodium glycyrrhizinate on the liver fluke Opisthorchis felineus: An in vitro and in vivo study.

  2019cites this paper
• Evaluation of the schistosomicidal, antioxidant and anti-inflammatory activities of the ethyl acetate fraction from Ozoroa pulcherrima Schweinf. Roots on Schistosoma mansoni-induced liver pathology in mice and its phytochemical characterization.

  2019cites this paper
• Oxidative stress in schistosomiasis, echinococcosis, and trypanosomiasis: a therapeutic approach

  2019cites this paper
• HPLC-ESI-MS Characterization of Certain Polyphenolic Compounds of Carica papaya L. Fruit Extracts and Evaluation of Their Potential Against Murine Schistosomiasis mansoni

  2018cites this paper
• Efficacy of Ozoroa pulcherrima Schweinf methanolic extract against Schistosoma mansoni-induced liver injury in mice

  2018cites this paper
• The Curative Effect of Berberine Nanoparticles and Cisplatin Combination Therapies Against Hepatocarcinogenesis-Induced By N-Nitroso-Diethylamine In Male Rat

  2018cites this paper
• Effects of Berberine chloride on the liver of streptozotocin-induced diabetes in albino Wistar rats.

  2018cites this paper
• Neuroprotective effects of berberine on recognition memory impairment, oxidative stress, and damage to the purinergic system in rats submitted to intracerebroventricular injection of streptozotocin

  2018cites this paper
• Anti‐influenza activity of berberine improves prognosis by reducing viral replication in mice

  2018cites this paper
• Berberine attenuate staphylococcal enterotoxin B-mediated acute liver injury via regulating HDAC expression

  2018cites this paper
• Efficacy of Sida pilosa Retz aqueous extract against Schistosoma mansoni – induced granulomatous inflammation in the liver and the intestine of mice: histomorphometry and gastrointestinal motility evaluation

  2018cites this paper
• Potential Prophylactic Effect of Berberine against Rat Colon Carcinoma Induce by 1,2-Dimethyl Hydrazine

  2018cites this paper
• The Effects of Berberine and Palmatine on Efflux Pumps Inhibition with Different Gene Patterns in Pseudomonas aeruginosa Isolated from Burn Infections

  2017cites this paper
• Pathological and biochemical alterations induced by synchronize lead intoxication and bilharzial Infection in mice

  2017cites this paper
• Effects of Pretreatment with Lead on Susceptibility and Resistance of Mice to Schistosomiasis

  2017cites this paper
• Protective role of selenium nanoparticles against Schistosoma mansoniinduced hepatic injury in mice.

  2016influential citation
• Role of berberine in Alzheimer’s disease

  2016cites this paper
• Ceratonia siliqua pod extract ameliorates Schistosoma mansoni-induced liver fibrosis and oxidative stress

  2016cites this paper
• Sodium valproate, a histone deacetylase inhibitor, with praziquantel ameliorates Schistosoma mansoni-induced liver fibrosis in mice.

  2016cites this paper
• Berberis Vulgaris and Berberine: An Update Review

  2016cites this paper
• Nanoparticles Against Schistosomiasis

  2016cites this paper
• Evaluation of Anthelmintic Activity and Composition of Pumpkin (Cucurbita pepo L.) Seed Extracts—In Vitro and in Vivo Studies

  2016cites this paper
• EFFICACY OF BERBERINE CHLORIDE ON HYPERGLYCEMIA IN STREPTOZOTOCIN INDUCED DIABETIC RATS

  2016cites this paper
• Impact of gold nanoparticles on brain of mice infected with Schistosoma mansoni

  2015cites this paper
• Berberine improves the intestinal antioxidant status of laboratory mice, Mus musculus

  2015cites this paper
• Antimicrobial Profile of Antidiabetic Drug: Berberine

  2015cites this paper
• Anti-Eimeria activity of berberine and identification of associated gene expression changes in the mouse jejunum infected with Eimeria papillata

  2015cites this paper
• Protective effect of berberine chloride on Plasmodium chabaudi-induced hepatic tissue injury in mice

  2014cites this paper
• Towards identifying novel anti-Eimeria agents: trace elements, vitamins, and plant-based natural products

  2014influential citation
• Journal of Drug Delivery and Therapeutics

  year unknowncites this paper