SCIENCE@home

Assessment of Insulin Resistance and its Correlation with 25-OH Vitamin D in Chronic Kidney Disease

Davendra Kumar,A. Mishra,M. S. Siddiqui,S. Ghosh,Shahnawaz S. Jafri

Published 2020 in International Journal of Contemporary Medical Research [IJCMR]

ABSTRACT

Introduction: Insulin resistance is more frequent at progressively declining glomerular filtration rate levels and is almost universal in end-stage kidney failure. Multiple studies have also demonstrated that 1,25(OH)2D administration improves glucose metabolism in patients with chronic kidney disease (CKD). The present study was carried out with an aim to assess insulin resistance and to find an association between eGFR, insulin resistance, and vitamin D levels in patients with chronic kidney disease. Material and Methods: This Cross-sectional study was conducted in a tertiary care academic hospital. Subjects with age ≥18 years; and estimated GFR <60 mL/min/1.73m2 were recruited. CKD was characterized as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m2 using a CockcroftGault equation. Insulin Resistance was assessed using the HOMA: HOMA-IR. Quantitative measurement of 25-OH vitamin D in serum and plasma samples was done using Chemiflex. Results: Among sixty-four enrolled subjects, 53.1% had insulin resistance. Insulin resistance showed an inverse relationship with eGFR (r= -0.50, p< 0.001), and metabolic acidosis (r= -0.39, p<0.001) while, it has no relation with vitamin D levels (r= -0.01, p<0.90). The study also shows that BMI (OR 1.43, 95% CI 0.99-2.07, p=0.05), waist circumference (OR 1.37, 95% CI 1.10-1.72, p=0.005), and metabolic acidosis (OR 5.71, 95% CI 1.85-17.61, p=0.002) were independently related to insulin resistance. Conclusion: The present study shows that eGFR and metabolic acidosis has an inverse association with insulin resistance in CKD patients. The study also shows that BMI, waist circumference, and metabolic acidosis were independently related to insulin resistance.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-32 of 32 references · Page 1 of 1

CITED BY

  • No citing papers are available for this paper.

Showing 0-0 of 0 citing papers · Page 1 of 1