ADP-ribosylation factor–like 4C binding to filamin-A modulates filopodium formation and cell migration

Filamin-A plays a key role in tumorigenesis as well as the metastatic progression of prostate cancer, ovarian cancer, and gastric carcinoma. In this study, we identified filamin-A as a novel effector of Arl4C and showed that binding between Arl4C and FLNa modulates the formation of filopodia and cell migration by promoting activation of Cdc42.

• Publication year

  2017

• Venue

  Molecular Biology of the Cell

• Publication date

  2017-08-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1091/mbc.E17-01-0059PMID 28855378PMCID 5662259
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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