Hepatic zinc concentrations in primary cancer of the liver.

ZINC plays an important role in wound healing (Pories et al., 1967) and may also be concerned with the body's attempt to localize malignant disease. The latter possibility is suggested by the finding of elevated zinc concentrations in the uninvolved portions of liver invaded by metastases (Olson, Heggen and Edwards, 1958; Wright and Dormandy, 1973) or in liver tissue when a neoplasm is present elsewhere (Olson et al., 1958; Wright and Dormandy, 1973), and also by the inhibitory effect of oral zinc on the development of certain tumours in experimental animals (Poswilo and Cohen, 1971). High zinc levels might then be expected in the unaffected liver tissue in patients with primary hepatic cancer (PLC). Investigation of this possibility is complicated by the fact that PLC frequently develops in cirrhotic livers (Sagebiel, McFarland and Taft, 1963; Lin, 1970), which may have subnormal zinc concentrations (Vallee et al., 1957; Butt and Higginson, 1957; Boyett and Sullivan, 1970). A comparison was therefore made between the zinc levels in both cirrhotic and non-cirrhotic livers associated with PLC and those in non-cirrhotic livers without PLC.

• Publication year

  1974

• Venue

  British Journal of Cancer

• Publication date

  1974-01-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/bjc.1974.11PMID 4820950PMCID 2009166
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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